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Protein

Histidinol-phosphate aminotransferase 1

Gene

hisC1

Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase regulatory subunit (hisZ), ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 1 (hisC1), Histidinol-phosphate aminotransferase 2 (hisC2)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00031; UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase 1 (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase 1
Gene namesi
Name:hisC1
Ordered Locus Names:NE0647
OrganismiNitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534041 – 359Histidinol-phosphate aminotransferase 1Add BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei218N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi228410.NE0647

Structurei

3D structure databases

ProteinModelPortaliQ82WM3
SMRiQ82WM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CIH Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiTYGMYKV
OrthoDBiPOG091H05S1
PhylomeDBiQ82WM3

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit

Sequencei

Sequence statusi: Complete.

Q82WM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSPSPDQVI RQEILALSAY HVPPAKDMVK LDAMENPYRL PPFLCEEISR
60 70 80 90 100
IAADTSINRY PDPHAAALKE VLSTTLSVPA GMEIMLGNGS DEIIQIIMLA
110 120 130 140 150
AAKPEAKLLT IEPGFAMFKM IATFANMQYI GIPLKPDFSL DIDRMLAAIE
160 170 180 190 200
RHQPSVIFLA YPNNPSGNLF DTSALEKIIE ISPGLVVIDE AYHPFAGKSF
210 220 230 240 250
IGRLADYPNL LVMRTLSKLG LAGLRLGLLA GRPEWLSHLE KLRLPYNVNV
260 270 280 290 300
ITQLVATKIM QHYDVLQQQA DAIRQTRTRL RTFLENLNGI EVFPSNANFI
310 320 330 340 350
LFRLDGASQI FRLLQQHGIL VKNLDNSHPL LKNCLRVTVG TPEENDRFCN

TLQDLIAGN
Length:359
Mass (Da):39,979
Last modified:June 1, 2003 - v1
Checksum:i9FFDFC0F831C969A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA Translation: CAD84558.1
RefSeqiWP_011111270.1, NC_004757.1

Genome annotation databases

EnsemblBacteriaiCAD84558; CAD84558; NE0647
KEGGineu:NE0647

Similar proteinsi

Entry informationi

Entry nameiHIS81_NITEU
AccessioniPrimary (citable) accession number: Q82WM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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