Reviewed, UniProtKB/Swiss-Prot Q82WM3 (HIS81_NITEU)

Names and origin

Protein names

Recommended name:
    Histidinol-phosphate aminotransferase 1
    EC=2.6.1.9
Alternative name(s):
    Imidazole acetol-phosphate transaminase 1

Gene names

Name:	hisC1
Ordered Locus Names:	NE0647

Organism

Nitrosomonas europaea [Complete proteome] [HAMAP]

Taxonomic identifier

915 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosomonas

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Histidinol-phosphate aminotransferase 1 HAMAP MF_01023		PRO_0000153404
Amino acid modifications
	Modified residue	218	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q82WM3-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 9FFDFC0F831C969A	FASTA	359	39,979
	10 20 30 40 50 60 MTSPSPDQVI RQEILALSAY HVPPAKDMVK LDAMENPYRL PPFLCEEISR IAADTSINRY 70 80 90 100 110 120 PDPHAAALKE VLSTTLSVPA GMEIMLGNGS DEIIQIIMLA AAKPEAKLLT IEPGFAMFKM 130 140 150 160 170 180 IATFANMQYI GIPLKPDFSL DIDRMLAAIE RHQPSVIFLA YPNNPSGNLF DTSALEKIIE 190 200 210 220 230 240 ISPGLVVIDE AYHPFAGKSF IGRLADYPNL LVMRTLSKLG LAGLRLGLLA GRPEWLSHLE 250 260 270 280 290 300 KLRLPYNVNV ITQLVATKIM QHYDVLQQQA DAIRQTRTRL RTFLENLNGI EVFPSNANFI 310 320 330 340 350 LFRLDGASQI FRLLQQHGIL VKNLDNSHPL LKNCLRVTVG TPEENDRFCN TLQDLIAGN

References

[1]

"Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea." Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J. J. Bacteriol. 185:2759-2773(2003) [PubMed: 12700255] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 19718 / IFO 14298.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL954747 Genomic DNA. Translation: CAD84558.1.
RefSeq	NP_840728.1.
3D structure databases
HSSP	HSSP built from PDB template 1GEW based on UniProtKB P06986.
ModBase	Search...
Genome annotation databases
GeneID	1081586.
GenomeReviews	Gene locus NE0647 in contig AL954747_GR.
KEGG	neu:NE0647.
NMPDR	fig|228410.1.peg.627.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q82WM3.
OMA	PEQLLIG.
Enzyme and pathway databases
BioCyc	NEUR228410:NE0647-MON.
BRENDA	2.6.1.9. 444.
Family and domain databases
HAMAP	MF_01023. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01141. hisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS81_NITEU

Accession

Primary (citable) accession number: Q82WM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)