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Q82W26

- HISX_NITEU

UniProt

Q82W26 - HISX_NITEU

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331NADUniRule annotation
    Binding sitei194 – 1941NADUniRule annotation
    Binding sitei217 – 2171NADUniRule annotation
    Binding sitei240 – 2401SubstrateUniRule annotation
    Metal bindingi262 – 2621ZincUniRule annotation
    Binding sitei262 – 2621SubstrateUniRule annotation
    Metal bindingi265 – 2651ZincUniRule annotation
    Binding sitei265 – 2651SubstrateUniRule annotation
    Active sitei330 – 3301Proton acceptorUniRule annotation
    Active sitei331 – 3311Proton acceptorUniRule annotation
    Binding sitei331 – 3311SubstrateUniRule annotation
    Metal bindingi364 – 3641ZincUniRule annotation
    Binding sitei364 – 3641SubstrateUniRule annotation
    Binding sitei418 – 4181SubstrateUniRule annotation
    Metal bindingi423 – 4231ZincUniRule annotation
    Binding sitei423 – 4231SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciNEUR228410:GJNO-894-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:NE0872
    OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
    Taxonomic identifieri228410 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
    ProteomesiUP000001416: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Histidinol dehydrogenasePRO_0000135805Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi228410.NE0872.

    Structurei

    3D structure databases

    ProteinModelPortaliQ82W26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiCAIANRI.
    OrthoDBiEOG6CVVCR.
    PhylomeDBiQ82W26.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q82W26-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKIRRLSSV DDHFQAELDQ LLSFEVSVDS EIERTVTQIL HQIRTHGDRA    50
    LLELTRQFDN PDIDRIEEIE LPRDEWQSAL MSLDKVQREA LEQAASRIRA 100
    YHEKQLAQSW DYVELDGTRL GQKITALDRV GLYVPGGKAA YPSSVLMNAI 150
    PARVAGVREL IMVTPTPKGE KNPLVLAAAA ICEVDRVFTI GGAQAVAALA 200
    YGTTTVPKVD KIVGPGNAYV AAAKRHVFGT VGIDMLAGPS EILVICDGKT 250
    NPDWIAMDLF SQAEHDEQAQ SILLCPDKAF LDRVADSISR LIDTLPRRDV 300
    IRSSLENRGA LIHVRDLEEA CMIANRIAPE HLELSVDEPE QWVDSIRHAG 350
    AIFLGRYTCE ALGDYCAGPN HVLPTSGTAR FSSPLGVYDF QKRTSLIQVS 400
    AAGASRLGET ASILAKGEGL DAHARSAESR YQ 432
    Length:432
    Mass (Da):47,371
    Last modified:June 1, 2003 - v1
    Checksum:iC687608394D9A3E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954747 Genomic DNA. Translation: CAD84783.1.
    RefSeqiNP_840946.1. NC_004757.1.
    WP_011111483.1. NC_004757.1.

    Genome annotation databases

    EnsemblBacteriaiCAD84783; CAD84783; NE0872.
    GeneIDi1081813.
    KEGGineu:NE0872.
    PATRICi22712754. VBINitEur56163_0979.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954747 Genomic DNA. Translation: CAD84783.1 .
    RefSeqi NP_840946.1. NC_004757.1.
    WP_011111483.1. NC_004757.1.

    3D structure databases

    ProteinModelPortali Q82W26.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228410.NE0872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD84783 ; CAD84783 ; NE0872 .
    GeneIDi 1081813.
    KEGGi neu:NE0872.
    PATRICi 22712754. VBINitEur56163_0979.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi CAIANRI.
    OrthoDBi EOG6CVVCR.
    PhylomeDBi Q82W26.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci NEUR228410:GJNO-894-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
      Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
      J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19718 / NBRC 14298.

    Entry informationi

    Entry nameiHISX_NITEU
    AccessioniPrimary (citable) accession number: Q82W26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3