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Q82W26 (HISX_NITEU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:NE0872
OrganismNitrosomonas europaea (strain ATCC 19718 / NBRC 14298) [Complete proteome] [HAMAP]
Taxonomic identifier228410 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135805

Sites

Active site3301Proton acceptor By similarity
Active site3311Proton acceptor By similarity
Metal binding2621Zinc By similarity
Metal binding2651Zinc By similarity
Metal binding3641Zinc By similarity
Metal binding4231Zinc By similarity
Binding site1331NAD By similarity
Binding site1941NAD By similarity
Binding site2171NAD By similarity
Binding site2401Substrate By similarity
Binding site2621Substrate By similarity
Binding site2651Substrate By similarity
Binding site3311Substrate By similarity
Binding site3641Substrate By similarity
Binding site4181Substrate By similarity
Binding site4231Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q82W26 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C687608394D9A3E4

FASTA43247,371
        10         20         30         40         50         60 
MIKIRRLSSV DDHFQAELDQ LLSFEVSVDS EIERTVTQIL HQIRTHGDRA LLELTRQFDN 

        70         80         90        100        110        120 
PDIDRIEEIE LPRDEWQSAL MSLDKVQREA LEQAASRIRA YHEKQLAQSW DYVELDGTRL 

       130        140        150        160        170        180 
GQKITALDRV GLYVPGGKAA YPSSVLMNAI PARVAGVREL IMVTPTPKGE KNPLVLAAAA 

       190        200        210        220        230        240 
ICEVDRVFTI GGAQAVAALA YGTTTVPKVD KIVGPGNAYV AAAKRHVFGT VGIDMLAGPS 

       250        260        270        280        290        300 
EILVICDGKT NPDWIAMDLF SQAEHDEQAQ SILLCPDKAF LDRVADSISR LIDTLPRRDV 

       310        320        330        340        350        360 
IRSSLENRGA LIHVRDLEEA CMIANRIAPE HLELSVDEPE QWVDSIRHAG AIFLGRYTCE 

       370        380        390        400        410        420 
ALGDYCAGPN HVLPTSGTAR FSSPLGVYDF QKRTSLIQVS AAGASRLGET ASILAKGEGL 

       430 
DAHARSAESR YQ 

« Hide

References

[1]"Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19718 / NBRC 14298.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL954747 Genomic DNA. Translation: CAD84783.1.
RefSeqNP_840946.1. NC_004757.1.

3D structure databases

ProteinModelPortalQ82W26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING228410.NE0872.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD84783; CAD84783; NE0872.
GeneID1081813.
KEGGneu:NE0872.
PATRIC22712754. VBINitEur56163_0979.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAPSEILII.
OrthoDBEOG6CVVCR.
ProtClustDBPRK00877.

Enzyme and pathway databases

BioCycNEUR228410:GJNO-894-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_NITEU
AccessionPrimary (citable) accession number: Q82W26
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways