SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q82W26

- HISX_NITEU

UniProt

Q82W26 - HISX_NITEU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Histidinol dehydrogenase
Gene
hisD, NE0872
Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331NAD By similarity
Binding sitei194 – 1941NAD By similarity
Binding sitei217 – 2171NAD By similarity
Binding sitei240 – 2401Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Metal bindingi265 – 2651Zinc By similarity
Binding sitei265 – 2651Substrate By similarity
Active sitei330 – 3301Proton acceptor By similarity
Active sitei331 – 3311Proton acceptor By similarity
Binding sitei331 – 3311Substrate By similarity
Metal bindingi364 – 3641Zinc By similarity
Binding sitei364 – 3641Substrate By similarity
Binding sitei418 – 4181Substrate By similarity
Metal bindingi423 – 4231Zinc By similarity
Binding sitei423 – 4231Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-894-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:NE0872
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Histidinol dehydrogenaseUniRule annotation
PRO_0000135805Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228410.NE0872.

Structurei

3D structure databases

ProteinModelPortaliQ82W26.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ82W26.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82W26-1 [UniParc]FASTAAdd to Basket

« Hide

MIKIRRLSSV DDHFQAELDQ LLSFEVSVDS EIERTVTQIL HQIRTHGDRA    50
LLELTRQFDN PDIDRIEEIE LPRDEWQSAL MSLDKVQREA LEQAASRIRA 100
YHEKQLAQSW DYVELDGTRL GQKITALDRV GLYVPGGKAA YPSSVLMNAI 150
PARVAGVREL IMVTPTPKGE KNPLVLAAAA ICEVDRVFTI GGAQAVAALA 200
YGTTTVPKVD KIVGPGNAYV AAAKRHVFGT VGIDMLAGPS EILVICDGKT 250
NPDWIAMDLF SQAEHDEQAQ SILLCPDKAF LDRVADSISR LIDTLPRRDV 300
IRSSLENRGA LIHVRDLEEA CMIANRIAPE HLELSVDEPE QWVDSIRHAG 350
AIFLGRYTCE ALGDYCAGPN HVLPTSGTAR FSSPLGVYDF QKRTSLIQVS 400
AAGASRLGET ASILAKGEGL DAHARSAESR YQ 432
Length:432
Mass (Da):47,371
Last modified:June 1, 2003 - v1
Checksum:iC687608394D9A3E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD84783.1.
RefSeqiNP_840946.1. NC_004757.1.
WP_011111483.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD84783; CAD84783; NE0872.
GeneIDi1081813.
KEGGineu:NE0872.
PATRICi22712754. VBINitEur56163_0979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD84783.1 .
RefSeqi NP_840946.1. NC_004757.1.
WP_011111483.1. NC_004757.1.

3D structure databases

ProteinModelPortali Q82W26.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228410.NE0872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD84783 ; CAD84783 ; NE0872 .
GeneIDi 1081813.
KEGGi neu:NE0872.
PATRICi 22712754. VBINitEur56163_0979.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q82W26.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci NEUR228410:GJNO-894-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiHISX_NITEU
AccessioniPrimary (citable) accession number: Q82W26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi