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Q82W22

- Q82W22_NITEU

UniProt

Q82W22 - Q82W22_NITEU

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation, TransferaseUniRule annotationSAAS annotation

Keywords - Biological processi

Purine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-898-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotationSAAS annotation
Gene namesi
Name:purHUniRule annotationImported
Ordered Locus Names:NE0876Imported
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)Imported
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi228410.NE0876.

Structurei

3D structure databases

ProteinModelPortaliQ82W22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Keywords - Domaini

TransmembraneImported

Phylogenomic databases

HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.
PhylomeDBiQ82W22.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82W22-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIKQALISV SDKTGIVELA AALHQFNITI LSTGGTARLL QESGIPVIEV
60 70 80 90 100
SDYTGFPEML DGRVKTLHPK VHAGILARMD LPEHRQVMEQ AQIPAIDLVV
110 120 130 140 150
VNLYPFTQTI TRPDCSFEEA IENIDIGGPT MIRAAAKNFQ RVAVVTDPQD
160 170 180 190 200
YGPLLEQIRA NDGSIDHDYR FQLAQKAFSH TARYDGAISN YLTALEPLSS
210 220 230 240 250
QRKRFPDQLN LSFTLAQPLR YGENPHQQAA FYRDTTNVPG SLADYDQLQG
260 270 280 290 300
KELSYNNIAD TDAAWACVRT FDKPACVIIK HANPCGVAIA DTALAAYKKA
310 320 330 340 350
FTTDPVSAFG GIIAINRAVE ADLAKAVLQQ FVEVIIAPEF SPEARHLLAD
360 370 380 390 400
KPNIRVLTVP LDKHNNVYDL KRVDGGLLVQ TPDDLDITVD QLQVVTRIKP
410 420 430 440 450
TREQIEDCLF AWRVAKFVKS NTIVFCANGQ TLGIGAGQMS RVDSARIASI
460 470 480 490 500
KAQQANLDLH GSVVASDAFF PFRDGLDVLA QAGAGVVIQP GGSIRDEEVI
510 520
AAADEQGVAM VFTGVRHFRH
Length:520
Mass (Da):56,796
Last modified:June 1, 2003 - v1
Checksum:i6376875F7A0E9394
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84787.1.
RefSeqiNP_840950.1. NC_004757.1.
WP_011111487.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD84787; CAD84787; NE0876.
GeneIDi1081817.
KEGGineu:NE0876.
PATRICi22712762. VBINitEur56163_0983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84787.1 .
RefSeqi NP_840950.1. NC_004757.1.
WP_011111487.1. NC_004757.1.

3D structure databases

ProteinModelPortali Q82W22.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228410.NE0876.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD84787 ; CAD84787 ; NE0876 .
GeneIDi 1081817.
KEGGi neu:NE0876.
PATRICi 22712762. VBINitEur56163_0983.

Phylogenomic databases

HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.
PhylomeDBi Q82W22.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci NEUR228410:GJNO-898-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298Imported.

Entry informationi

Entry nameiQ82W22_NITEU
AccessioniPrimary (citable) accession number: Q82W22
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

External Data

Dasty 3