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Q82W22

- Q82W22_NITEU

UniProt

Q82W22 - Q82W22_NITEU

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotationSAAS annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    HydrolaseUniRule annotationSAAS annotation, TransferaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Purine biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciNEUR228410:GJNO-898-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Gene namesi
    Name:purHUniRule annotationImported
    Ordered Locus Names:NE0876Imported
    OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)Imported
    Taxonomic identifieri228410 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
    ProteomesiUP000001416: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Interactioni

    Protein-protein interaction databases

    STRINGi228410.NE0876.

    Structurei

    3D structure databases

    ProteinModelPortaliQ82W22.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Keywords - Domaini

    TransmembraneImported

    Phylogenomic databases

    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiCGVATGP.
    OrthoDBiEOG6QCDFF.
    PhylomeDBiQ82W22.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q82W22-1 [UniParc]FASTAAdd to Basket

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    MSIKQALISV SDKTGIVELA AALHQFNITI LSTGGTARLL QESGIPVIEV    50
    SDYTGFPEML DGRVKTLHPK VHAGILARMD LPEHRQVMEQ AQIPAIDLVV 100
    VNLYPFTQTI TRPDCSFEEA IENIDIGGPT MIRAAAKNFQ RVAVVTDPQD 150
    YGPLLEQIRA NDGSIDHDYR FQLAQKAFSH TARYDGAISN YLTALEPLSS 200
    QRKRFPDQLN LSFTLAQPLR YGENPHQQAA FYRDTTNVPG SLADYDQLQG 250
    KELSYNNIAD TDAAWACVRT FDKPACVIIK HANPCGVAIA DTALAAYKKA 300
    FTTDPVSAFG GIIAINRAVE ADLAKAVLQQ FVEVIIAPEF SPEARHLLAD 350
    KPNIRVLTVP LDKHNNVYDL KRVDGGLLVQ TPDDLDITVD QLQVVTRIKP 400
    TREQIEDCLF AWRVAKFVKS NTIVFCANGQ TLGIGAGQMS RVDSARIASI 450
    KAQQANLDLH GSVVASDAFF PFRDGLDVLA QAGAGVVIQP GGSIRDEEVI 500
    AAADEQGVAM VFTGVRHFRH 520
    Length:520
    Mass (Da):56,796
    Last modified:June 1, 2003 - v1
    Checksum:i6376875F7A0E9394
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954747 Genomic DNA. Translation: CAD84787.1.
    RefSeqiNP_840950.1. NC_004757.1.

    Genome annotation databases

    EnsemblBacteriaiCAD84787; CAD84787; NE0876.
    GeneIDi1081817.
    KEGGineu:NE0876.
    PATRICi22712762. VBINitEur56163_0983.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL954747 Genomic DNA. Translation: CAD84787.1 .
    RefSeqi NP_840950.1. NC_004757.1.

    3D structure databases

    ProteinModelPortali Q82W22.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 228410.NE0876.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD84787 ; CAD84787 ; NE0876 .
    GeneIDi 1081817.
    KEGGi neu:NE0876.
    PATRICi 22712762. VBINitEur56163_0983.

    Phylogenomic databases

    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi CGVATGP.
    OrthoDBi EOG6QCDFF.
    PhylomeDBi Q82W22.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci NEUR228410:GJNO-898-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
      Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
      J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19718 / NBRC 14298Imported.

    Entry informationi

    Entry nameiQ82W22_NITEU
    AccessioniPrimary (citable) accession number: Q82W22
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

    External Data

    Dasty 3