Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q82W22 (Q82W22_NITEU) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
Gene names
Name:purH HAMAP-Rule MF_00139
Ordered Locus Names:NE0876
OrganismNitrosomonas europaea (strain ATCC 19718 / NBRC 14298) [Complete proteome] [HAMAP]
Taxonomic identifier228410 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Nitrosomonadales › Nitrosomonadaceae › Nitrosomonas ›

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. SAAS SAAS024051 HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. SAAS SAAS024051 HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. SAAS SAAS024051 HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. SAAS SAAS024051 HAMAP-Rule MF_00139

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family. HAMAP-Rule MF_00139

Sequences

Sequence LengthMass (Da)Tools
Q82W22 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 6376875F7A0E9394

FASTA52056,796
        10         20         30         40         50         60 
MSIKQALISV SDKTGIVELA AALHQFNITI LSTGGTARLL QESGIPVIEV SDYTGFPEML 

        70         80         90        100        110        120 
DGRVKTLHPK VHAGILARMD LPEHRQVMEQ AQIPAIDLVV VNLYPFTQTI TRPDCSFEEA 

       130        140        150        160        170        180 
IENIDIGGPT MIRAAAKNFQ RVAVVTDPQD YGPLLEQIRA NDGSIDHDYR FQLAQKAFSH 

       190        200        210        220        230        240 
TARYDGAISN YLTALEPLSS QRKRFPDQLN LSFTLAQPLR YGENPHQQAA FYRDTTNVPG 

       250        260        270        280        290        300 
SLADYDQLQG KELSYNNIAD TDAAWACVRT FDKPACVIIK HANPCGVAIA DTALAAYKKA 

       310        320        330        340        350        360 
FTTDPVSAFG GIIAINRAVE ADLAKAVLQQ FVEVIIAPEF SPEARHLLAD KPNIRVLTVP 

       370        380        390        400        410        420 
LDKHNNVYDL KRVDGGLLVQ TPDDLDITVD QLQVVTRIKP TREQIEDCLF AWRVAKFVKS 

       430        440        450        460        470        480 
NTIVFCANGQ TLGIGAGQMS RVDSARIASI KAQQANLDLH GSVVASDAFF PFRDGLDVLA 

       490        500        510        520 
QAGAGVVIQP GGSIRDEEVI AAADEQGVAM VFTGVRHFRH

« Hide

References

[1]"Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19718 / NBRC 14298.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL954747 Genomic DNA. Translation: CAD84787.1.
RefSeqNP_840950.1. NC_004757.1.

3D structure databases

HSSPHSSP built from PDB template 1PKX based on UniProtKB P31939.
ProteinModelPortalQ82W22.
ModBaseSearch...

Protein-protein interaction databases

STRING228410.NE0876.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD84787; CAD84787; NE0876.
GeneID1081817.
KEGGneu:NE0876.
PATRIC22712762. VBINitEur56163_0983.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycNEUR228410:GJNO-898-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF53927. Cytidine_deaminase-like. 1 hit.
SSF52335. MGS-like_dom. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ82W22_NITEU
AccessionPrimary (citable) accession number: Q82W22
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info