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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-1014-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:NE0991
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001416 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000109192Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228410.NE0991.

Structurei

3D structure databases

ProteinModelPortaliQ82VS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218321.
KOiK02563.
OMAiEQNALPG.
OrthoDBiEOG61VZFD.
PhylomeDBiQ82VS3.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82VS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMAGGTGGH VFPGLAVARS MQANGWRIVW LGTRNGMEAA LVPQHGFSIE
60 70 80 90 100
LINFSGLRGK KLSSYLLLPW RLAQACWQSF RILRRQQPQV VLGMGGYPAL
110 120 130 140 150
PGGIMAVLLG KPLLIHEQNR IAGLTNKILA KIADRILLAF PGALTSPENK
160 170 180 190 200
TRVTGNPVRT EIARLPSPEA RYAHRTGNLH ILVVGGSLGA QVLNTVLPQA
210 220 230 240 250
LSMIPEDQRP YVTHQSGKAH LDALQQAYAD HGVTGNLVAF IENMAAHYQD
260 270 280 290 300
CDLVICRAGA LTISELAAAG VASILIPYPY AVDDHQTANA RFLSDYQAAV
310 320 330 340 350
LWPQSELTAA SLAQWLMTCS RAQLQSMATH ARALAMPEAA QTVAEACQQL

SGQTNEA
Length:357
Mass (Da):38,390
Last modified:June 1, 2003 - v1
Checksum:iF4E1828EF0ED80FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84902.1.
RefSeqiWP_011111600.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD84902; CAD84902; NE0991.
KEGGineu:NE0991.
PATRICi22713002. VBINitEur56163_1102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD84902.1.
RefSeqiWP_011111600.1. NC_004757.1.

3D structure databases

ProteinModelPortaliQ82VS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228410.NE0991.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD84902; CAD84902; NE0991.
KEGGineu:NE0991.
PATRICi22713002. VBINitEur56163_1102.

Phylogenomic databases

eggNOGiENOG4105DVQ. Bacteria.
COG0707. LUCA.
HOGENOMiHOG000218321.
KOiK02563.
OMAiEQNALPG.
OrthoDBiEOG61VZFD.
PhylomeDBiQ82VS3.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciNEUR228410:GJNO-1014-MONOMER.

Family and domain databases

HAMAPiMF_00033. MurG.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiMURG_NITEU
AccessioniPrimary (citable) accession number: Q82VS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: June 1, 2003
Last modified: November 11, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.