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Q82VD1

- GCH4_NITEU

UniProt

Q82VD1 - GCH4_NITEU

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei154 – 1541May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-1188-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:NE1163
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268GTP cyclohydrolase FolE2PRO_0000147717Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228410.NE1163.

Structurei

Secondary structure

1
268
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 3714
Turni40 – 423
Beta strandi45 – 5713
Helixi63 – 675
Helixi68 – 758
Beta strandi78 – 814
Helixi82 – 843
Helixi85 – 9511
Beta strandi99 – 11416
Turni116 – 1183
Beta strandi121 – 13515
Turni136 – 1383
Beta strandi139 – 15315
Helixi155 – 1606
Beta strandi161 – 1633
Beta strandi167 – 18014
Helixi184 – 19411
Beta strandi195 – 1984
Helixi205 – 21612
Helixi222 – 23413
Beta strandi239 – 24911
Turni251 – 2533
Beta strandi254 – 26411

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2R5RX-ray3.05A1-268[»]
ProteinModelPortaliQ82VD1.
SMRiQ82VD1. Positions 20-265.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ82VD1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.
PhylomeDBiQ82VD1.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82VD1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKQIDLPIA DVQGSLDTRH IAIDRVGIKA IRHPVVVADK GGGSQHTVAQ
60 70 80 90 100
FNMYVNLPHN FKGTHMSRFV EILNSHEREI SVESFEEILR SMVSRLESDS
110 120 130 140 150
GHIEMAFPYF INKSAPVSGV KSLLDYEVTF IGEIKHGNQY SFTMKVIVPV
160 170 180 190 200
TSLCPCSKKI SDYGAHNQRS HVTISVRTNS FIWIEDIIRI AEEQASCELY
210 220 230 240 250
GLLKRPDEKY VTERAYNNPK FVEDIVRDVA EVLNHDDRID AYIVESENFE
260
SIHNHSAYAL IERDKRIR
Length:268
Mass (Da):30,604
Last modified:June 1, 2003 - v1
Checksum:iDAA9B16495ED23E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD85074.1.
RefSeqiNP_841220.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD85074; CAD85074; NE1163.
GeneIDi1082107.
KEGGineu:NE1163.
PATRICi22713382. VBINitEur56163_1290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL954747 Genomic DNA. Translation: CAD85074.1 .
RefSeqi NP_841220.1. NC_004757.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2R5R X-ray 3.05 A 1-268 [» ]
ProteinModelPortali Q82VD1.
SMRi Q82VD1. Positions 20-265.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 228410.NE1163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD85074 ; CAD85074 ; NE1163 .
GeneIDi 1082107.
KEGGi neu:NE1163.
PATRICi 22713382. VBINitEur56163_1290.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.
PhylomeDBi Q82VD1.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci NEUR228410:GJNO-1188-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q82VD1.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.
  2. "The crystal structure of duf198 from Nitrosomonas europaea ATCC 19718."
    Midwest center for structural genomics (MCSG)
    Submitted (SEP-2007) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.05 ANGSTROMS).

Entry informationi

Entry nameiGCH4_NITEU
AccessioniPrimary (citable) accession number: Q82VD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3