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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei154May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:NE1163
OrganismiNitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
Proteomesi
  • UP000001416 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477171 – 268GTP cyclohydrolase FolE2Add BLAST268

Interactioni

Protein-protein interaction databases

STRINGi228410.NE1163.

Structurei

Secondary structure

1268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 37Combined sources14
Turni40 – 42Combined sources3
Beta strandi45 – 57Combined sources13
Helixi63 – 67Combined sources5
Helixi68 – 75Combined sources8
Beta strandi78 – 81Combined sources4
Helixi82 – 84Combined sources3
Helixi85 – 95Combined sources11
Beta strandi99 – 114Combined sources16
Turni116 – 118Combined sources3
Beta strandi121 – 135Combined sources15
Turni136 – 138Combined sources3
Beta strandi139 – 153Combined sources15
Helixi155 – 160Combined sources6
Beta strandi161 – 163Combined sources3
Beta strandi167 – 180Combined sources14
Helixi184 – 194Combined sources11
Beta strandi195 – 198Combined sources4
Helixi205 – 216Combined sources12
Helixi222 – 234Combined sources13
Beta strandi239 – 249Combined sources11
Turni251 – 253Combined sources3
Beta strandi254 – 264Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R5RX-ray3.05A1-268[»]
ProteinModelPortaliQ82VD1.
SMRiQ82VD1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ82VD1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA. Bacteria.
COG1469. LUCA.
HOGENOMiHOG000280679.
KOiK09007.
OMAiINMYVDL.
OrthoDBiPOG091H0MIO.
PhylomeDBiQ82VD1.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82VD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQIDLPIA DVQGSLDTRH IAIDRVGIKA IRHPVVVADK GGGSQHTVAQ
60 70 80 90 100
FNMYVNLPHN FKGTHMSRFV EILNSHEREI SVESFEEILR SMVSRLESDS
110 120 130 140 150
GHIEMAFPYF INKSAPVSGV KSLLDYEVTF IGEIKHGNQY SFTMKVIVPV
160 170 180 190 200
TSLCPCSKKI SDYGAHNQRS HVTISVRTNS FIWIEDIIRI AEEQASCELY
210 220 230 240 250
GLLKRPDEKY VTERAYNNPK FVEDIVRDVA EVLNHDDRID AYIVESENFE
260
SIHNHSAYAL IERDKRIR
Length:268
Mass (Da):30,604
Last modified:June 1, 2003 - v1
Checksum:iDAA9B16495ED23E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD85074.1.
RefSeqiWP_011111754.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD85074; CAD85074; NE1163.
KEGGineu:NE1163.
PATRICi22713382. VBINitEur56163_1290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD85074.1.
RefSeqiWP_011111754.1. NC_004757.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R5RX-ray3.05A1-268[»]
ProteinModelPortaliQ82VD1.
SMRiQ82VD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228410.NE1163.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD85074; CAD85074; NE1163.
KEGGineu:NE1163.
PATRICi22713382. VBINitEur56163_1290.

Phylogenomic databases

eggNOGiENOG4105DZA. Bacteria.
COG1469. LUCA.
HOGENOMiHOG000280679.
KOiK09007.
OMAiINMYVDL.
OrthoDBiPOG091H0MIO.
PhylomeDBiQ82VD1.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Miscellaneous databases

EvolutionaryTraceiQ82VD1.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B. 1 hit.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGCH4_NITEU
AccessioniPrimary (citable) accession number: Q82VD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.