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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei351 – 3511Proton donorUniRule annotation
Active sitei382 – 3821UniRule annotation
Active sitei510 – 5101UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciNEUR228410:GJNO-2308-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:NE2263
OrganismiNitrosomonas europaea (strain ATCC 19718 / NBRC 14298)
Taxonomic identifieri228410 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosomonas
ProteomesiUP000001416 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Glucose-6-phosphate isomerasePRO_0000180695Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi228410.NE2263.

Structurei

3D structure databases

ProteinModelPortaliQ82SP4.
SMRiQ82SP4. Positions 2-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiSHLIAPY.
OrthoDBiEOG64R61J.
PhylomeDBiQ82SP4.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82SP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTLTRSPAW LALSAHQTEI ANRPLRTLFD EDPQRFDKFS LQFKDLLLDY
60 70 80 90 100
SKQPVDATTI RLLLALAEQQ KLVDWLGRMA NGEKINFTES RAALHIALRA
110 120 130 140 150
NSPVFMDGVD VTQEVRRVLR QIEQFVQKIH NQSHRGYSGL PITDVVNIGI
160 170 180 190 200
GGSDLGPVMV TEALKPYHLP QLRTHFVSNL DGAHLSDTLQ HINPATTLFV
210 220 230 240 250
IASKTFTTQE TLANAHSARK WFLAGGGSKQ DIAAHFVAVS TNREAVSQFG
260 270 280 290 300
IDPDNMFEFW DWVGGRYSLW SAIGLPIALA VGMEHFHSLL AGAQAMDDHF
310 320 330 340 350
LTAPFEQNLP VILGLIGIWQ INFFHITSQA ILPYDQSMHR FPAYLQQLEM
360 370 380 390 400
ESNGKRVTRN GEAVDYSTGI IIWGEPGTNG QHAFYQLLHQ GTQKFTADFL
410 420 430 440 450
APCRCHHPLS EHHPMLLANF FAQTEALMRG KTEQEVRSEL ANQNLSADLV
460 470 480 490 500
EHLLPHRVFP GNHATTSILF KKLDPATLGM LIALYEHKVF VQSVIWEINP
510 520 530 540
FDQWGVELGK QLAGKILAEL ALDKPVTGHD ASTNGLINFY RAQQ
Length:544
Mass (Da):60,902
Last modified:June 1, 2003 - v1
Checksum:iA4BEF605C8A38CF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD86175.1.
RefSeqiWP_011112754.1. NC_004757.1.

Genome annotation databases

EnsemblBacteriaiCAD86175; CAD86175; NE2263.
KEGGineu:NE2263.
PATRICi22715925. VBINitEur56163_2540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL954747 Genomic DNA. Translation: CAD86175.1.
RefSeqiWP_011112754.1. NC_004757.1.

3D structure databases

ProteinModelPortaliQ82SP4.
SMRiQ82SP4. Positions 2-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi228410.NE2263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAD86175; CAD86175; NE2263.
KEGGineu:NE2263.
PATRICi22715925. VBINitEur56163_2540.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiSHLIAPY.
OrthoDBiEOG64R61J.
PhylomeDBiQ82SP4.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciNEUR228410:GJNO-2308-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the ammonia-oxidizing bacterium and obligate chemolithoautotroph Nitrosomonas europaea."
    Chain P., Lamerdin J.E., Larimer F.W., Regala W., Lao V., Land M.L., Hauser L., Hooper A.B., Klotz M.G., Norton J., Sayavedra-Soto L.A., Arciero D.M., Hommes N.G., Whittaker M.M., Arp D.J.
    J. Bacteriol. 185:2759-2773(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19718 / NBRC 14298.

Entry informationi

Entry nameiG6PI_NITEU
AccessioniPrimary (citable) accession number: Q82SP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.