Reviewed, UniProtKB/Swiss-Prot Q82P98 (PPNK1_STRAW)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 1
      Short name=Poly(P)/ATP NAD kinase 1
    EC=2.7.1.23

Gene names

Name:	ppnK1
Ordered Locus Names:	SAV_1035

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity.
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Probable inorganic polyphosphate/ATP-NAD kinase 1 HAMAP MF_00361		PRO_0000229698

Sequences

	Sequence		Length	Mass (Da)
	Q82P98-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 4A17FAC7731B5C4D	FASTA	357	37,612
	10 20 30 40 50 60 MTVTRVGLVM HGGRAQAGDA ARIVRGWCAE RGVHCADIDV WRDDTRHSAR EEVAAAGNPD 70 80 90 100 110 120 LIVTLGGDGT FLRGARLAAE NDALVLGVDL GRVGFLTEVP AAAVCEALEA VQEDRITVES 130 140 150 160 170 180 RMLLTLRASR RLQVPTGMEA LLRYGRGPLL PPPRVRTDCA EGDDWGIALH VTALNDIVLE 190 200 210 220 230 240 KLARDRQVSV GVYLAGRLLA SYSADALLVA TPTGSTAYSF AAGGPVVSPR AEALIFTPVA 250 260 270 280 290 300 PHMAFNRSVV AAPDEPIALR VLDRSGPAAV SVDGQLRGVL DPGDWIGVYA APRRLKAVRL 310 320 330 340 350 GPMDFYGRLR ERMNLTDAPA AVADGQAAPL WPVTSAPPAD LAHLTLPPGP GDTPSAS

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000030 Genomic DNA. Translation: BAC68745.1.
RefSeq	NP_822210.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1212671.
GenomeReviews	Gene locus SAV_1035 in contig BA000030_GR.
KEGG	sma:SAV_1035.
NMPDR	fig|227882.1.peg.1036.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q82P98.
OMA	HSAREEV.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV1035-MON.
BRENDA	2.7.1.23. 140873.
Family and domain databases
HAMAP	MF_00361. [Tree]
InterPro	IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK1_STRAW

Accession

Primary (citable) accession number: Q82P98

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)