Reviewed, UniProtKB/Swiss-Prot Q82NQ8 (IOLG_STRAW)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	SAV_1234

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352597

Sequences

	Sequence		Length	Mass (Da)
	Q82NQ8-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B4A714DA68E57C01	FASTA	343	36,308
	10 20 30 40 50 60 MSQLLGVAVL GAGHMGADHI RRLDSVVSGA RVAAVADPAK ERAEEAVAGL DGVLVHTEVA 70 80 90 100 110 120 AALDAPGVEA VLIASPGPAH EEALLAAFAR GLPVLCEKPM VPDSAGALRI VEAEARLGRR 130 140 150 160 170 180 LAQVGFMRRY DAEYMGLKSL LDSGRLGRPL MLHCTHRNVS SPPGFTSAML INSSVSHEID 190 200 210 220 230 240 AARWLLGQEL TAVTVLRPRP SAHAPEGLLD PQFVLFETAG GALVDVEILV NSGFGYQVRC 250 260 270 280 290 300 EAVCEAGSVR IGDAHTMVVT SAGGAYQEVA QDYLVRFADA YDREVREWVD ATRRGQVTGP 310 320 330 340 SAWDGYAASV VAEAGVRAQD TGDRMTVELA PRPDLYGQNP ISR

References

[1]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

[2]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000030 Genomic DNA. Translation: BAC68944.1.
RefSeq	NP_822409.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1210158.
GenomeReviews	Gene locus SAV_1234 in contig BA000030_GR.
KEGG	sma:SAV_1234.
NMPDR	fig|227882.1.peg.1235.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q82NQ8.
OMA	YAAAAVC.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV1234-MONOMER.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_STRAW

Accession

Primary (citable) accession number: Q82NQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)