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Q82NI9

- GLSA_STRAW

UniProt

Q82NI9 - GLSA_STRAW

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Protein
Glutaminase
Gene
glsA, SAV_1314
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731Substrate By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei174 – 1741Substrate By similarity
Binding sitei198 – 1981Substrate By similarity
Binding sitei249 – 2491Substrate By similarity
Binding sitei267 – 2671Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-1321-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase (EC:3.5.1.2)
Gene namesi
Name:glsA
Ordered Locus Names:SAV_1314
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313GlutaminaseUniRule annotation
PRO_0000110626Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_1314.

Structurei

3D structure databases

ProteinModelPortaliQ82NI9.

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiYLKETNY.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82NI9-1 [UniParc]FASTAAdd to Basket

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MVIMSASWSS HAFQPVLERI ADEIERTPGR GRPADYIPAL AACDPRRFGM    50
AVAELDGTVY GVGDWRQPFS TQSITKVFTL ALDLAREGDA LWEHVGREPS 100
GNPFNSLVQL EYESGIPRNP FINAGALVVT DRLQTQTGDA AGSLLEFLRA 150
ESGNPRLTFD QDVAASEAAH GDRNAALGHF MASYGNIDNS VPVLLDQYFR 200
QCSIEASCAD LALATGFLAR HGIRADGSRL LTQSQAKQVN AVMLTCGTYD 250
AAGDFAYRVG LPGKSGVGGG IIAVVPGRCT LCVWSPGLDE RGNSVAGVAA 300
LDRFTTLTGV SVF 313
Length:313
Mass (Da):33,299
Last modified:June 1, 2003 - v1
Checksum:iF77B2789DBC2781D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000030 Genomic DNA. Translation: BAC69024.1.
RefSeqiNP_822489.1. NC_003155.4.
WP_010982752.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC69024; BAC69024; SAV_1314.
GeneIDi1210180.
KEGGisma:SAV_1314.
PATRICi23715967. VBIStrAve112782_1401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000030 Genomic DNA. Translation: BAC69024.1 .
RefSeqi NP_822489.1. NC_003155.4.
WP_010982752.1. NC_003155.4.

3D structure databases

ProteinModelPortali Q82NI9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227882.SAV_1314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC69024 ; BAC69024 ; SAV_1314 .
GeneIDi 1210180.
KEGGi sma:SAV_1314.
PATRICi 23715967. VBIStrAve112782_1401.

Phylogenomic databases

eggNOGi COG2066.
HOGENOMi HOG000216890.
KOi K01425.
OMAi YLKETNY.
OrthoDBi EOG6N94BK.

Enzyme and pathway databases

BioCyci SAVE227882:GJU1-1321-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
HAMAPi MF_00313. Glutaminase.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view ]
PANTHERi PTHR12544. PTHR12544. 1 hit.
Pfami PF04960. Glutaminase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
TIGRFAMsi TIGR03814. Gln_ase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiGLSA_STRAW
AccessioniPrimary (citable) accession number: Q82NI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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