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Protein

Alpha-galactosidase

Gene

agaB2

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.UniRule annotation

GO - Molecular functioni

  1. raffinose alpha-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-1483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-galactosidaseUniRule annotation (EC:3.2.1.22UniRule annotation)
Alternative name(s):
MelibiaseUniRule annotation
Gene namesi
Name:agaB2Imported
Ordered Locus Names:SAV_1475Imported
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)Imported
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428 Componenti: Chromosome

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_1475.

Structurei

3D structure databases

ProteinModelPortaliQ82N28.
SMRiQ82N28. Positions 55-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 27 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000161224.
KOiK07407.
OMAiDISDSWG.
OrthoDBiEOG6N0HK6.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR018905. A-galactase_NEW3.
IPR013785. Aldolase_TIM.
IPR008979. Galactose-bd-like.
IPR013222. Glyco_hyd_98_carb-bd.
IPR013780. Glyco_hydro_13_b.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_GHD.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF02065. Melibiase. 1 hit.
PF08305. NPCBM. 1 hit.
PF10633. NPCBM_assoc. 1 hit.
[Graphical view]
PRINTSiPR00740. GLHYDRLASE27.
SMARTiSM00776. NPCBM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00512. ALPHA_GALACTOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82N28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHPYARTTR TTRTTRTTRR RVVGALTAGL LCTAGLAAPA LAAPAAGPVS
60 70 80 90 100
PRPADSLALT PPMGFNNWNS TGCRPEFNED MVKGTADIFV EKGLKDAGYQ
110 120 130 140 150
YVNLDDCWAL PARDSNGKLV PDPARFPGGI KAVADYVHSK GLKLGIYTSA
160 170 180 190 200
GTKTCNEAGF PGALGHEYSD AQQFADWGVD YLKYDNCNNQ GVDAKLRYTT
210 220 230 240 250
MRDALKATGR PIVYSLCEWG ENKPWEWASD VGQLWRTTGD ISDSWGSMLS
260 270 280 290 300
ILKQNLPLAP YAGPGHWNDP DMLEVGNSGM TDTEYRTHFS MWSIMAAPLL
310 320 330 340 350
IGSDLRKASA ATFDILDNKE VIAVDQDPLG KQGTVLSSEG GRWAVTKEMK
360 370 380 390 400
DGSRAVALFN ETDSAQRITT TAQAVGLPKA HAYTLRDLWQ HRSYNTAGTI
410 420 430 440 450
SATVPAHGTV LVRVSADAAW AKNPPAVELG VDGSPLLEAG RTVALTSALT
460 470 480 490 500
DLGRTPAKRV SVTLSGPRGW RVRATSPTTA GTVPTGRSLR TKWKVTAPDG
510 520 530 540 550
TAAGSYDLTL KATYRSPTGV RAETLVPLAA SVVPAPPSGV SYLGDLPWMS
560 570 580 590 600
TTNGWGPVER NTSNGESAAG DGRPITVDGV VHAKGIGVHA ESTIAYYTGR
610 620 630 640 650
SCETVTADVG VDDEQDTNGS VTFEIWADGT RVASTGVLTT AMPARPLSAD
660 670 680
VTGAQVVRLV VTDGGNGITS DHADWADAKL SC
Length:682
Mass (Da):72,330
Last modified:June 1, 2003 - v1
Checksum:iCE6AE06B08C99759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC69185.1.
RefSeqiNP_822650.1. NC_003155.4.
WP_010982913.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC69185; BAC69185; SAV_1475.
KEGGisma:SAV_1475.
PATRICi23716315. VBIStrAve112782_1574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC69185.1.
RefSeqiNP_822650.1. NC_003155.4.
WP_010982913.1. NC_003155.4.

3D structure databases

ProteinModelPortaliQ82N28.
SMRiQ82N28. Positions 55-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_1475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC69185; BAC69185; SAV_1475.
KEGGisma:SAV_1475.
PATRICi23716315. VBIStrAve112782_1574.

Phylogenomic databases

HOGENOMiHOG000161224.
KOiK07407.
OMAiDISDSWG.
OrthoDBiEOG6N0HK6.

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-1483-MONOMER.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProiIPR018905. A-galactase_NEW3.
IPR013785. Aldolase_TIM.
IPR008979. Galactose-bd-like.
IPR013222. Glyco_hyd_98_carb-bd.
IPR013780. Glyco_hydro_13_b.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_GHD.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF02065. Melibiase. 1 hit.
PF08305. NPCBM. 1 hit.
PF10633. NPCBM_assoc. 1 hit.
[Graphical view]
PRINTSiPR00740. GLHYDRLASE27.
SMARTiSM00776. NPCBM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEiPS00512. ALPHA_GALACTOSIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680Imported.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiQ82N28_STRAW
AccessioniPrimary (citable) accession number: Q82N28
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 1, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.