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Protein

Glucose-6-phosphate isomerase 1

Gene

pgi1

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathway:iglycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase 2 (pgi2), Glucose-6-phosphate isomerase 1 (pgi1)
  3. Putative 6-phosphofructokinase (pfkA2), Putative 6-phosphofructokinase (pfkA3), Putative 6-phosphofructokinase (pfkA1)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei358 – 3581Proton donorUniRule annotation
Active sitei389 – 3891UniRule annotation
Active sitei513 – 5131UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-1781-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 1UniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPI 1UniRule annotation
Alternative name(s):
Phosphoglucose isomerase 1UniRule annotation
Short name:
PGI 1UniRule annotation
Phosphohexose isomerase 1UniRule annotation
Short name:
PHI 1UniRule annotation
Gene namesi
Name:pgi1UniRule annotation
Ordered Locus Names:SAV_1770
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
ProteomesiUP000000428 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomerase 1PRO_0000180747Add
BLAST

Proteomic databases

PRIDEiQ82M90.

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_1770.

Structurei

3D structure databases

ProteinModelPortaliQ82M90.
SMRiQ82M90. Positions 3-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiISVMMAY.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82M90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSPRLTRR PEWTELEDHR AGPLLHPALR ELFAADPERA ERYVVRAGDL
60 70 80 90 100
RLDYSKHLIT DETLALLQEL ATATDVFGLR DAMFRGEKIN VTENRAVLHT
110 120 130 140 150
ALRAPRDAVI EVDGENVVPA VHAVLDRMAD FADRVRSGEW TGHTGSRIRT
160 170 180 190 200
VVNIGIGGSD LGPAMAYEAL RAFTDRSLTV RFVSNVDGAD LHEAVRDLDP
210 220 230 240 250
AETLFVIASK TFTTIETITN ATSARSWLLA GLDGDEKAVA KHFVALSTNA
260 270 280 290 300
GKVSDFGIDT ANMFEFWDWV GGRYSFDSAI GLSLMIAIGP ERFRELLDGF
310 320 330 340 350
RIVDEHFRTA PAEANAPLLL GLLGVWYGSF FGAQSHAVLP YSHYLSKFTA
360 370 380 390 400
YLQQLDMESN GKSVDRDGHP VEWQTGPVVW GTPGTNGQHA YYQLLHQGTK
410 420 430 440 450
VIPADLIGFI NPVDGLSDEL AAQHDLLMAN LFAQGQALAF GKTGDEVRAE
460 470 480 490 500
GVPEEQVPHR TFRGNHPTTT ILAAELTPSV LGQLIALYEH KVFVQGAIWN
510 520 530 540
IDSFDQWGVE LGKVLAKRVE PALTEGADVP GLDPSTAALV AAYRTHRKK
Length:549
Mass (Da):60,210
Last modified:June 1, 2003 - v1
Checksum:iB856B99B5D47BC19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC69481.1.
RefSeqiWP_010983209.1. NZ_BAVY01000019.1.

Genome annotation databases

EnsemblBacteriaiBAC69481; BAC69481; SAV_1770.
KEGGisma:SAV_1770.
PATRICi23716941. VBIStrAve112782_1885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC69481.1.
RefSeqiWP_010983209.1. NZ_BAVY01000019.1.

3D structure databases

ProteinModelPortaliQ82M90.
SMRiQ82M90. Positions 3-548.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_1770.

Proteomic databases

PRIDEiQ82M90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC69481; BAC69481; SAV_1770.
KEGGisma:SAV_1770.
PATRICi23716941. VBIStrAve112782_1885.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiISVMMAY.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciSAVE227882:GJU1-1781-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiG6PI1_STRAW
AccessioniPrimary (citable) accession number: Q82M90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.