Reviewed, UniProtKB/Swiss-Prot Q82M90 (G6PI1_STRAW)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase 1
      Short name=GPI 1
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase 1
      Short name=PGI 1
    Phosphohexose isomerase 1
      Short name=PHI 1

Gene names

Name:	pgi1
Ordered Locus Names:	SAV_1770

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	549 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 549	549	Glucose-6-phosphate isomerase 1 HAMAP MF_00473		PRO_0000180747
Sites
	Active site	358	1	Proton donor By similarity
	Active site	389	1	By similarity
	Active site	513	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q82M90-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B856B99B5D47BC19	FASTA	549	60,210
	10 20 30 40 50 60 MSDSPRLTRR PEWTELEDHR AGPLLHPALR ELFAADPERA ERYVVRAGDL RLDYSKHLIT 70 80 90 100 110 120 DETLALLQEL ATATDVFGLR DAMFRGEKIN VTENRAVLHT ALRAPRDAVI EVDGENVVPA 130 140 150 160 170 180 VHAVLDRMAD FADRVRSGEW TGHTGSRIRT VVNIGIGGSD LGPAMAYEAL RAFTDRSLTV 190 200 210 220 230 240 RFVSNVDGAD LHEAVRDLDP AETLFVIASK TFTTIETITN ATSARSWLLA GLDGDEKAVA 250 260 270 280 290 300 KHFVALSTNA GKVSDFGIDT ANMFEFWDWV GGRYSFDSAI GLSLMIAIGP ERFRELLDGF 310 320 330 340 350 360 RIVDEHFRTA PAEANAPLLL GLLGVWYGSF FGAQSHAVLP YSHYLSKFTA YLQQLDMESN 370 380 390 400 410 420 GKSVDRDGHP VEWQTGPVVW GTPGTNGQHA YYQLLHQGTK VIPADLIGFI NPVDGLSDEL 430 440 450 460 470 480 AAQHDLLMAN LFAQGQALAF GKTGDEVRAE GVPEEQVPHR TFRGNHPTTT ILAAELTPSV 490 500 510 520 530 540 LGQLIALYEH KVFVQGAIWN IDSFDQWGVE LGKVLAKRVE PALTEGADVP GLDPSTAALV AAYRTHRKK

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000030 Genomic DNA. Translation: BAC69481.1.
RefSeq	NP_822946.1.
3D structure databases
SMR	Q82M90. Positions 3-548.
ModBase	Search...
Genome annotation databases
GeneID	1210279.
GenomeReviews	Gene locus SAV_1770 in contig BA000030_GR.
KEGG	sma:SAV_1770.
NMPDR	fig|227882.1.peg.1772.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG352954.
OMA	PARETIV.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV1770-MONOMER.
BRENDA	5.3.1.9. 140873.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI1_STRAW

Accession

Primary (citable) accession number: Q82M90

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	June 1, 2003
Last modified:	January 19, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)