Q82M40 (FCTA_STRAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formyl-coenzyme A transferase
Short name=Formyl-CoA transferase
EC=2.8.3.16

Gene names

Name:	frc
Ordered Locus Names:	SAV_1820

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate By similarity. HAMAP MF_00742
Catalytic activity	Formyl-CoA + oxalate = formate + oxalyl-CoA. HAMAP MF_00742
Pathway	Metabolic intermediate degradation; oxalate degradation; CO(2) and formate from oxalate: step 1/2. HAMAP MF_00742
Sequence similarities	Belongs to the CaiB/BaiF CoA-transferase family.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	formyl-CoA transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Formyl-coenzyme A transferase HAMAP MF_00742		PRO_0000194723
Sites
	Active site	167	1	Nucleophile By similarity
	Binding site	95	1	Coenzyme A By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q82M40 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 8204C8A684585A7B	FASTA	409	44,360
	10 20 30 40 50 60 MTKALEGIRV LDMTHVQSGP SATQLLAWLG ADVVKLEAPT GDITRGQLRD LPDVDSLYFT 70 80 90 100 110 120 MLNCNKRSIT LNTKTERGKE ILTELIRRSD VMVENFGPGA VDRMGFTWDR IRDINPRIVY 130 140 150 160 170 180 ASIKGFGDGP YTDFKAYEVV AQAMGGSMST TGFEDGPPLA TGAQIGDSGT GIHAVAGILA 190 200 210 220 230 240 ALYQRENTGR GQRVNVAMQH AVLNLCRVKL RDQQRLAHGP LAEYPNDDFG DEVPRSGNAS 250 260 270 280 290 300 GGGQPGWAVK CAPGGPNDYV YVIVQPVGWK PLSELIGRPE LADDPEWATP EARLPQLTKM 310 320 330 340 350 360 FQLIEEWSAT LPKWEVLEKL NAHNIPCGPI LSTKEIVEDA SLVANEMVVT VPHPERGEFV 370 380 390 400 TVGSPLKLSD SPVDVTSSPL LGEHNAEVYV GELGLGDEEL RLLKSNGVI

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000030 Genomic DNA. Translation: BAC69531.1.
RefSeq	NP_822996.1. NC_003155.4.
3D structure databases
ProteinModelPortal	Q82M40.
SMR	Q82M40. Positions 1-409.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1213305.
GenomeReviews	Gene locus SAV_1820 in contig BA000030_GR.
KEGG	sma:SAV_1820.
NMPDR	fig|227882.1.peg.1822.
PATRIC	23717055. VBIStrAve112782_1941.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG659028.
OMA	NDYVYVI.
ProtClustDB	PRK05398.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV1820-MONOMER.
Family and domain databases
HAMAP	MF_00742. Formyl-CoA_transfer. [Tree]
InterPro	IPR003673. CoA-Trfase_fam_III. IPR023606. CoA-Trfase_III_dom. IPR017659. Formyl-CoA_transferase. [Graphical view]
Gene3D	G3DSA:3.40.50.10540. CoA-Trfase_fam_III. 1 hit.
KO	K07749.
PANTHER	PTHR11837. CAIB_BAIF. 1 hit.
Pfam	PF02515. CoA_transf_3. 1 hit. [Graphical view]
SUPFAM	SSF89796. CoA-Trfase_fam_III. 1 hit.
TIGRFAMs	TIGR03253. Oxalate_frc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FCTA_STRAW

Accession

Primary (citable) accession number: Q82M40

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program