ID   Q82M18_STRAW            Unreviewed;       625 AA.
AC   Q82M18;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 121.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   Name=neuA1 {ECO:0000313|EMBL:BAC69553.1};
GN   ORFNames=SAVERM_1842 {ECO:0000313|EMBL:BAC69553.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC69553.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC69553.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC69553.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; BA000030; BAC69553.1; -; Genomic_DNA.
DR   RefSeq; WP_010983281.1; NZ_JZJK01000086.1.
DR   AlphaFoldDB; Q82M18; -.
DR   KEGG; sma:SAVERM_1842; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_430157_0_0_11; -.
DR   OrthoDB; 7294637at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd00110; LamG; 1.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006558; LamG-like.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF13385; Laminin_G_3; 1.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00560; LamGL; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..625
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004300078"
FT   DOMAIN          457..596
FT                   /note="LamG-like jellyroll fold"
FT                   /evidence="ECO:0000259|SMART:SM00560"
FT   DOMAIN          457..591
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|SMART:SM00282"
FT   REGION          270..293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   625 AA;  67137 MW;  CAD6DA2F546FEAD7 CRC64;
     MPSTLRARIA STLTAVLTTA ALLALPSPAG AEQATDTGEF EQQVLFKASQ DPGYACFRIP
     AVVKTTDGTL LAFAEGRVLN CGDAADIDIV LKRSTDGGRT WGPLQVVNEG GGDTHGNPAP
     VVDRETGRIV LAETYNTGRT DSAGCTVPCD RTPHLQYSDD DGLTWSRPRD LSDEILPPEW
     NSWYATGPVH GIQLTRGRHA GRLVLGVNTE TWDGSRVSAN HAALITSDDG GDHWRIGATD
     SWPIAADGTF RQKPSEMTLA ERTDGSVLVS GREQDGTDLG HRTQAVSRDG GSSFTAPFRD
     LPDLYTPQVQ GSSLRLGDRL LLACPGDPDR RRTMTIRSSY DGGRTWDSVD RGTVVTTDWS
     GYSDLVRVGR DTVGLMYEGG AVDARDEIRF ARFTEDWLKP RRGPDPTTPD LAPHAKGAAV
     LGGAEQTEGV FGGALDFDGA DDAVRLPYRA ELPLGTKDFT ASLWFRYTAA TGEQPLLWMG
     GIGTSQPQVW LRGEPASNRV QGLITVRDGA SAPQSAFVRT TGAYNDGQWH HLALRRGGGA
     LTLFLDGTPI STADVPGSVS RNSPFGVHIG QRMDSRAYFT GSIDEVRVYG RALSDAEITG
     LRTDNEASAR DTVLRLPMDR VSGSH
//