Q82LU4 (PSD_STRAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	SAV_1916

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 184	184	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029809
	Chain	185 – 215	31	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029810
Sites
	Site	184 – 185	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	185	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q82LU4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 89BEA04ABA706B8C	FASTA	215	23,338
	10 20 30 40 50 60 MPHSQTSAPR GRVRLARGAS PWLLPTVATA ALSLVRARRS GAAKAVAVPA TALAAGMLWF 70 80 90 100 110 120 FRDPEREITQ GRVISPADGV VQSIMPWKDG RTRVAIFMSP LNVHVNRAPL SGTVTSVEHI 130 140 150 160 170 180 PGGFVPAFNK ESENNERVVW HFDTELGDIE MIQIAGAVAR RIVPYVPQGT KVEQGDRIGL 190 200 210 IRFGSRVDIY LPEGVDVDVE VGQKTVAGVT RIDRD

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000030 Genomic DNA. Translation: BAC69627.1.
RefSeq	NP_823092.1. NC_003155.4.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1213375.
GenomeReviews	Gene locus SAV_1916 in contig BA000030_GR.
KEGG	sma:SAV_1916.
NMPDR	fig|227882.1.peg.1918.
PATRIC	23717271. VBIStrAve112782_2049.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG541103.
OMA	NERVVWH.
ProtClustDB	PRK05305.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV1916-MONOMER.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase-related. [Graphical view]
KO	K01613.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_STRAW

Accession

Primary (citable) accession number: Q82LU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program