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Q82LL4

- ALLB_STRAW

UniProt

Q82LL4 - ALLB_STRAW

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Protein
Allantoinase
Gene
allB, pucH, sav1996, SAV_1996
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring By similarity.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Zinc 1 By similarity
Metal bindingi65 – 651Zinc 1 By similarity
Metal bindingi150 – 1501Zinc 1; via carbamate group By similarity
Metal bindingi150 – 1501Zinc 2; via carbamate group By similarity
Metal bindingi186 – 1861Zinc 2 By similarity
Metal bindingi238 – 2381Zinc 2 By similarity
Metal bindingi311 – 3111Zinc 1 By similarity

GO - Molecular functioni

  1. allantoinase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: UniProtKB-HAMAP
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-2009-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoinase (EC:3.5.2.5)
Alternative name(s):
Allantoin-utilizing enzyme
Gene namesi
Name:allB
Synonyms:pucH, sav1996
Ordered Locus Names:SAV_1996
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445AllantoinaseUniRule annotation
PRO_0000317687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501N6-carboxylysine By similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions By similarity.UniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_1996.

Structurei

3D structure databases

ProteinModelPortaliQ82LL4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiRWMSTAP.
OrthoDBiEOG6KHFW6.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82LL4-1 [UniParc]FASTAAdd to Basket

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MSDVELVLRS TRVITPEGTR PAAVAVAAGK ITAVLPHDAE VPAGARLEDL    50
GDDVLLPGLV DTHVHVNDPG RTHWEGFWTA TRAAAAGGIT TLVDMPLNSL 100
PPTTTVGNLR TKRDVAADKA HIDVGFWGGA LPDNVKDLRP LHDAGVFGFK 150
AFLSPSGVDE FPELDQERLA RSMAEIAGFG GLLIVHAEDP HHLAAAPQRG 200
GPRYTDFLAS RPRDAEDTAI ANLLAQAKRL NARVHVLHLS SSDALPLIAG 250
AKAEGVRVTV ETCPHYLTLT AEEVPDGASE FKCCPPIREA ANQDLLWQAL 300
ADGTIDCVVT DHSPSTADLK TDDFATAWGG ISGLQLSLPA IWTEARRRGH 350
SLEDVVRWMS ARTARLVGLA QKGAIEAGRD ADFAVLAPDE TFTVDPAALQ 400
HRNRVTAYAG KTLSGVVKST WLRGERIMAD GEFTEPKGRL LSREP 445
Length:445
Mass (Da):47,582
Last modified:June 1, 2003 - v1
Checksum:i3C75AF72F136425C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000030 Genomic DNA. Translation: BAC69707.1.
RefSeqiNP_823172.1. NC_003155.4.
WP_010983436.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC69707; BAC69707; SAV_1996.
GeneIDi1210332.
KEGGisma:SAV_1996.
PATRICi23717441. VBIStrAve112782_2134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000030 Genomic DNA. Translation: BAC69707.1 .
RefSeqi NP_823172.1. NC_003155.4.
WP_010983436.1. NC_003155.4.

3D structure databases

ProteinModelPortali Q82LL4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227882.SAV_1996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC69707 ; BAC69707 ; SAV_1996 .
GeneIDi 1210332.
KEGGi sma:SAV_1996.
PATRICi 23717441. VBIStrAve112782_2134.

Phylogenomic databases

eggNOGi COG0044.
HOGENOMi HOG000219146.
KOi K01466.
OMAi RWMSTAP.
OrthoDBi EOG6KHFW6.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .
BioCyci SAVE227882:GJU1-2009-MONOMER.

Family and domain databases

Gene3Di 2.30.40.10. 1 hit.
HAMAPi MF_01645. Hydantoinase.
InterProi IPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiALLB_STRAW
AccessioniPrimary (citable) accession number: Q82LL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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