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Protein
Submitted name:

Putative sulfate adenylyltransferase large subunit

Gene

cysN1

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

May be the GTPase, regulating ATP sulfurylase activity.SAAS annotation

Catalytic activityi

ATP + sulfate = diphosphate + adenylyl sulfate.SAAS annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. GTPase activity Source: InterPro
  3. GTP binding Source: UniProtKB-KW
  4. nucleotidyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen sulfide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, GTP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-2145-MONOMER.
UniPathwayiUPA00140; UER00204.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative sulfate adenylyltransferase large subunitImported
Gene namesi
Name:cysN1Imported
Ordered Locus Names:SAV_2132Imported
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)Imported
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

Interactioni

Subunit structurei

Heterodimer composed of CysD, the smaller subunit, and CysN.SAAS annotation

Protein-protein interaction databases

STRINGi227882.SAV_2132.

Structurei

3D structure databases

ProteinModelPortaliQ82L80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains tr-type G (guanine nucleotide-binding) domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000229289.
KOiK00956.
OMAiREFQANI.
OrthoDBiEOG6GR38Q.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR011779. SO4_adenylTrfase_lsu.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02034. CysN. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82L80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTTEPTEP LSVEQLSATT LLRFATAGSV DDGKSTLVGR LLHDSKSVLT
60 70 80 90 100
DQLEAVEQVS RSRGQDAPDL ALLTDGLRAE REQGITIDVA YRYFATARRR
110 120 130 140 150
FILADTPGHV QYTRNMVTGA STADLAVVLV DARNGVIEQT RRHAAVAALL
160 170 180 190 200
RVPHVVLAVN KMDLVEYKES VFAAIAEKFT AYASELGVPE ITAIPISALA
210 220 230 240 250
GDNVVDASAN MDWYGGPTVL EHLETVPVSH DLAHCHARLP VQYVIRPQTA
260 270 280 290 300
EHPDYRGYAG QIAAGTFCVG SEVTVLPSGR TSKIAGIDLL GTPVDVAWTP
310 320 330 340 350
QSVTLLLEDD IDISRGDLLV PSKDAPATTQ DVEATVCHVA DAPLTVGHRV
360 370 380 390 400
LLKHGTRTVK AIVKDIPSRL TLDDLSLAPA PGAAGRQRHR PRQDPYRRAA
410 420 430 440 450
AARLVRRLPP HRRVHPDRPG GRHDADRGHG RRVLRRARAG QGRERRRRVG
460 470 480
LLIMTTTDFY STFAKEGGRV GSGALGSGQG GVARCAR
Length:487
Mass (Da):52,533
Last modified:June 1, 2003 - v1
Checksum:i179E92C89BF3E560
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC69843.1.
RefSeqiNP_823308.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC69843; BAC69843; SAV_2132.
GeneIDi1210353.
KEGGisma:SAV_2132.
PATRICi23717733. VBIStrAve112782_2284.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC69843.1.
RefSeqiNP_823308.1. NC_003155.4.

3D structure databases

ProteinModelPortaliQ82L80.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_2132.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC69843; BAC69843; SAV_2132.
GeneIDi1210353.
KEGGisma:SAV_2132.
PATRICi23717733. VBIStrAve112782_2284.

Phylogenomic databases

HOGENOMiHOG000229289.
KOiK00956.
OMAiREFQANI.
OrthoDBiEOG6GR38Q.

Enzyme and pathway databases

UniPathwayiUPA00140; UER00204.
BioCyciSAVE227882:GJU1-2145-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR011779. SO4_adenylTrfase_lsu.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02034. CysN. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680Imported.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiQ82L80_STRAW
AccessioniPrimary (citable) accession number: Q82L80
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.