ID   Q82L49_STRAW            Unreviewed;       725 AA.
AC   Q82L49;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=Terpene synthase {ECO:0000256|RuleBase:RU366034};
DE            EC=4.2.3.- {ECO:0000256|RuleBase:RU366034};
GN   Name=geoA {ECO:0000313|EMBL:BAC69874.1};
GN   ORFNames=SAVERM_2163 {ECO:0000313|EMBL:BAC69874.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC69874.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC69874.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC69874.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946,
CC         ECO:0000256|RuleBase:RU366034};
CC   -!- SIMILARITY: Belongs to the terpene synthase family.
CC       {ECO:0000256|RuleBase:RU366034}.
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DR   EMBL; BA000030; BAC69874.1; -; Genomic_DNA.
DR   RefSeq; WP_010983603.1; NZ_JZJK01000086.1.
DR   AlphaFoldDB; Q82L49; -.
DR   DNASU; 1210359; -.
DR   KEGG; sma:SAVERM_2163; -.
DR   eggNOG; ENOG502Z881; Bacteria.
DR   HOGENOM; CLU_372108_0_0_11; -.
DR   OrthoDB; 2989600at2; -.
DR   BRENDA; 4.1.99.16; 5980.
DR   BRENDA; 4.2.3.22; 5980.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00687; Terpene_cyclase_nonplant_C1; 1.
DR   Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 2.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR034686; Terpene_cyclase-like_2.
DR   PANTHER; PTHR35201; TERPENE SYNTHASE; 1.
DR   PANTHER; PTHR35201:SF4; TERPENE SYNTHASE; 1.
DR   Pfam; PF19086; Terpene_syn_C_2; 2.
DR   SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 2.
DR   SFLD; SFLDG01020; Terpene_Cyclase_Like_2; 2.
DR   SUPFAM; SSF48576; Terpenoid synthases; 2.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366034};
KW   Magnesium {ECO:0000256|RuleBase:RU366034};
KW   Metal-binding {ECO:0000256|RuleBase:RU366034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428}.
SQ   SEQUENCE   725 AA;  81686 MW;  EBB06B889C5E6480 CRC64;
     MTQPFQLPHF YMPYPARLNP HLDEARAHST RWARGMGMLE GSGIWEQSDL DAHDYGLLCA
     YTHPDCDGPA LSLITDWYVW VFFFDDHFLE TFKRTQDREG GKAYLDRLPL FMPLDLSAPV
     PEPENPVEAG LADLWARTVP AMSADWRKRF AVSTEHLLNE SLWELSNINE GRIANPVEYI
     EMRRKVGGAP WSAGLVEYAT AEVPAAVAGS RPLRVLMETF SDGVHLRNDL FSYQREVEEE
     GELSNGVLVL ETFFGCTTQE AAETVNDILT SRLHQFEHTA LTEVPALALE KGLTPPEVAA
     VAAYARGLQD WQSGGHEWHL RSSRYMNEGA LSQKRPFGLS AIGTSAADLR GLLADAGAER
     LRRYTHVPFQ KVGPSRIPDF HMPFQVELSP HLEGARARLT PWMHSTGMLQ EGVWDEDKLT
     AYDLPLCSAG LDPDATPDEL DLSSRWLAWG TYGDDYYPMV FGPRRDLAAA KLCTRRLSAC
     MPVDGEEVPA PVNGMERGLI DLWAITTAEM TPDERRTFRA SVDVMTESWV WELSNQLQHR
     IPDPIDYLEM RRATFGADLT LSLCRVGHGP KVPPEIYRSG PVRSLENAAV DYGMLINDVF
     SYQKEIEYEG EVHNAILVVQ NFFGCDYPTA LGVINDLMTQ RMHQFEHVAA HELPLLYKDF
     KLPQEVRDIM DGYVVELQNW MSGILKWHQD CHRYGAADLA RRAHGFVPDR APSAPFTAWA
     APVAR
//