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Protein

Ferrochelatase

Gene

hemH

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi191 – 1911IronUniRule annotation
Metal bindingi286 – 2861IronUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-2419-MONOMER.
UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:SAV_2407
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375FerrochelatasePRO_0000175209Add
BLAST

Proteomic databases

PRIDEiQ82KJ6.

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_2407.

Structurei

3D structure databases

ProteinModelPortaliQ82KJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QME. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060728.
KOiK01772.
OMAiHENVGGR.
OrthoDBiEOG65TRQC.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82KJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEALDASPY DALLLLSFGG PEGPDDVVPF LENVTRGRGI PRERLKEVGQ
60 70 80 90 100
HYFLFGGISP INDQNRALLD ALRKDFAEHG LNLPVYWGNR NWAPYLTDTL
110 120 130 140 150
REMAADGRRR ILVLATSAYA SYSGCRQYRE NLAGALATLE AEGLEVPRVD
160 170 180 190 200
KLRHYFNHPG FVEPMTEGVL RSLAELPEDV RPGAHIAFTT HSIPTAAADT
210 220 230 240 250
SGPVEEHGDG GAYVKQHLDV ARLIADAVRE ETGIDHPWQL VYQSRSGAPH
260 270 280 290 300
IPWLEPDICD HLQELHGAGV PAVVMAPIGF VSDHMEVLYD LDTEAKAKAE
310 320 330 340 350
ELGLPVRRSA TVGADARFAA AVRELVVERA AVESGQKVTP CALGALGPSH
360 370
QLCPVGCCPA RAPKPAAAGA DSPYA
Length:375
Mass (Da):40,494
Last modified:June 1, 2003 - v1
Checksum:iC47EBD50BA91B8E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70118.1.
RefSeqiWP_010983844.1. NZ_JZJK01000086.1.

Genome annotation databases

EnsemblBacteriaiBAC70118; BAC70118; SAV_2407.
KEGGisma:SAV_2407.
PATRICi23718307. VBIStrAve112782_2571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70118.1.
RefSeqiWP_010983844.1. NZ_JZJK01000086.1.

3D structure databases

ProteinModelPortaliQ82KJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_2407.

Proteomic databases

PRIDEiQ82KJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC70118; BAC70118; SAV_2407.
KEGGisma:SAV_2407.
PATRICi23718307. VBIStrAve112782_2571.

Phylogenomic databases

eggNOGiENOG4107QME. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060728.
KOiK01772.
OMAiHENVGGR.
OrthoDBiEOG65TRQC.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.
BioCyciSAVE227882:GJU1-2419-MONOMER.

Family and domain databases

HAMAPiMF_00323. Ferrochelatase.
InterProiIPR001015. Ferrochelatase.
[Graphical view]
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiPF00762. Ferrochelatase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiHEMH_STRAW
AccessioniPrimary (citable) accession number: Q82KJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: November 11, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.