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Q82KJ6 (HEMH_STRAW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:SAV_2407
OrganismStreptomyces avermitilis [Complete proteome] [HAMAP]
Taxonomic identifier33903 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Ferrochelatase HAMAP MF_00323
PRO_0000175209

Sites

Metal binding1911Iron By similarity
Metal binding2861Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q82KJ6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: C47EBD50BA91B8E1

FASTA37540,494
        10         20         30         40         50         60 
MPEALDASPY DALLLLSFGG PEGPDDVVPF LENVTRGRGI PRERLKEVGQ HYFLFGGISP 

        70         80         90        100        110        120 
INDQNRALLD ALRKDFAEHG LNLPVYWGNR NWAPYLTDTL REMAADGRRR ILVLATSAYA 

       130        140        150        160        170        180 
SYSGCRQYRE NLAGALATLE AEGLEVPRVD KLRHYFNHPG FVEPMTEGVL RSLAELPEDV 

       190        200        210        220        230        240 
RPGAHIAFTT HSIPTAAADT SGPVEEHGDG GAYVKQHLDV ARLIADAVRE ETGIDHPWQL 

       250        260        270        280        290        300 
VYQSRSGAPH IPWLEPDICD HLQELHGAGV PAVVMAPIGF VSDHMEVLYD LDTEAKAKAE 

       310        320        330        340        350        360 
ELGLPVRRSA TVGADARFAA AVRELVVERA AVESGQKVTP CALGALGPSH QLCPVGCCPA 

       370 
RAPKPAAAGA DSPYA

« Hide

References

[1]"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.
[2]"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000030 Genomic DNA. Translation: BAC70118.1.
RefSeqNP_823583.1. NC_003155.4.

3D structure databases

ProteinModelPortalQ82KJ6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1210424.
GenomeReviewsGene locus SAV_2407 in contig BA000030_GR.
KEGGsma:SAV_2407.
NMPDRfig|227882.1.peg.2409.
PATRIC23718307. VBIStrAve112782_2571.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAPAVVMAP.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycSAVE227882:SAV2407-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
PROSITEPS00534. FERROCHELATASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_STRAW
AccessionPrimary (citable) accession number: Q82KJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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