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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi572 – 577ATPPROSITE-ProRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Chromosome partition
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:SAV_2510
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Topological domaini237 – 905CytoplasmicSequence analysisAdd BLAST669

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000983031 – 905DNA translocase FtsKAdd BLAST905

Proteomic databases

PRIDEiQ82K93

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi227882.SAV_2510

Structurei

3D structure databases

ProteinModelPortaliQ82K93
SMRiQ82K93
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini552 – 752FtsKPROSITE-ProRule annotationAdd BLAST201

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QZI Bacteria
COG1674 LUCA
HOGENOMiHOG000010002
KOiK03466
OMAiKSSCINC
OrthoDBiPOG091H01S4

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR002543 FtsK_dom
IPR018541 Ftsk_gamma
IPR027417 P-loop_NTPase
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF09397 Ftsk_gamma, 1 hit
PF01580 FtsK_SpoIIIE, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00843 Ftsk_gamma, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50901 FTSK, 1 hit

Sequencei

Sequence statusi: Complete.

Q82K93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRQPAAKK PPAKKAAVPT KAPAKKAPAK KAAVRKAPAR KVAAKKPAPK
60 70 80 90 100
PAPNPTGGVY KLARALWLGV AHAVGAMFRG IGQGAKGLDP AHRKDGLALL
110 120 130 140 150
LLGLALIVAA GTWSNLRGPV GDLVEMLVTG AFGRLDLLVP ILLAVIAVRF
160 170 180 190 200
IRHPEKPEAN GRIVIGLSAL VIGVLGQVHI ACGAPARSDG MQAIRDAGGL
210 220 230 240 250
IGWSAATPLT YTMGDVLAVP LLVLLTVFGL LVVTATPVNA IPQRLRLLGV
260 270 280 290 300
RLGVVHDAQE GLAEDDERYD EQWREALPPN ARRRGPAPAG YDPDGDEQEA
310 320 330 340 350
LSKRRSRPRR SAGQQPDLNR PMDAVDVAAA AAAALDGAVL HGMPPSPLVA
360 370 380 390 400
DLTQGVTVER DGYEETTPVP AARAKAVKPP RKEASKAGVP DLTKAPPAET
410 420 430 440 450
RDLPARAEQL QLSGDITYSL PSLDLLERGG PGKTRSAAND AVVASLSNVF
460 470 480 490 500
MEFKVDAAVT GFTRGPTVTR YEVELGPAVK VERITALTKN IAYAVASPDV
510 520 530 540 550
RIISPIPGKS AVGIEIPNTD REMVNLGDVL RLADAAEDDH PMLVALGKDV
560 570 580 590 600
EGGYVMANLA KMPHLLVAGA TGSGKSSCIN CLITSVMVRA TPEDVRMVLV
610 620 630 640 650
DPKRVELTAY EGIPHLITPI ITNPKRAAEA LQWVVREMDL RYDDLAAFGY
660 670 680 690 700
RHIDDFNEAI RNGKVKLPEG SERELSPYPY LLVIVDELAD LMMVAPRDVE
710 720 730 740 750
DAIVRITQLA RAAGIHLVLA TQRPSVDVVT GLIKANVPSR LAFATSSLAD
760 770 780 790 800
SRVILDQPGA EKLIGKGDGL FLPMGANKPT RMQGAFVTED EVEAVVQHCK
810 820 830 840 850
DQMAPVFRDD VTVGTKQKKE IDEDIGDDLD LLCQAAELVV STQFGSTSML
860 870 880 890 900
QRKLRVGFAK AGRLMDLMES RNIVGPSEGS KARDVLVKAD ELDGVLAVIR

GEAAP
Length:905
Mass (Da):96,091
Last modified:August 29, 2003 - v2
Checksum:iEC2A47698AF6CFC0
GO

Sequence cautioni

The sequence BAC70221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC70221.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiBAC70221; BAC70221; SAVERM_2510
KEGGisma:SAVERM_2510

Similar proteinsi

Entry informationi

Entry nameiFTSK_STRAW
AccessioniPrimary (citable) accession number: Q82K93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: May 23, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health