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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi572 – 5776ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-2522-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:SAV_2510
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8521HelicalSequence analysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence analysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence analysisAdd
BLAST
Topological domaini237 – 905669CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 905905DNA translocase FtsKPRO_0000098303Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Protein-protein interaction databases

STRINGi227882.SAV_2510.

Structurei

3D structure databases

ProteinModelPortaliQ82K93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini552 – 752201FtsKPROSITE-ProRule annotationAdd
BLAST

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QZI. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000010002.
KOiK03466.
OMAiAEDDHPM.
OrthoDBiEOG6S52GD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82K93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRQPAAKK PPAKKAAVPT KAPAKKAPAK KAAVRKAPAR KVAAKKPAPK
60 70 80 90 100
PAPNPTGGVY KLARALWLGV AHAVGAMFRG IGQGAKGLDP AHRKDGLALL
110 120 130 140 150
LLGLALIVAA GTWSNLRGPV GDLVEMLVTG AFGRLDLLVP ILLAVIAVRF
160 170 180 190 200
IRHPEKPEAN GRIVIGLSAL VIGVLGQVHI ACGAPARSDG MQAIRDAGGL
210 220 230 240 250
IGWSAATPLT YTMGDVLAVP LLVLLTVFGL LVVTATPVNA IPQRLRLLGV
260 270 280 290 300
RLGVVHDAQE GLAEDDERYD EQWREALPPN ARRRGPAPAG YDPDGDEQEA
310 320 330 340 350
LSKRRSRPRR SAGQQPDLNR PMDAVDVAAA AAAALDGAVL HGMPPSPLVA
360 370 380 390 400
DLTQGVTVER DGYEETTPVP AARAKAVKPP RKEASKAGVP DLTKAPPAET
410 420 430 440 450
RDLPARAEQL QLSGDITYSL PSLDLLERGG PGKTRSAAND AVVASLSNVF
460 470 480 490 500
MEFKVDAAVT GFTRGPTVTR YEVELGPAVK VERITALTKN IAYAVASPDV
510 520 530 540 550
RIISPIPGKS AVGIEIPNTD REMVNLGDVL RLADAAEDDH PMLVALGKDV
560 570 580 590 600
EGGYVMANLA KMPHLLVAGA TGSGKSSCIN CLITSVMVRA TPEDVRMVLV
610 620 630 640 650
DPKRVELTAY EGIPHLITPI ITNPKRAAEA LQWVVREMDL RYDDLAAFGY
660 670 680 690 700
RHIDDFNEAI RNGKVKLPEG SERELSPYPY LLVIVDELAD LMMVAPRDVE
710 720 730 740 750
DAIVRITQLA RAAGIHLVLA TQRPSVDVVT GLIKANVPSR LAFATSSLAD
760 770 780 790 800
SRVILDQPGA EKLIGKGDGL FLPMGANKPT RMQGAFVTED EVEAVVQHCK
810 820 830 840 850
DQMAPVFRDD VTVGTKQKKE IDEDIGDDLD LLCQAAELVV STQFGSTSML
860 870 880 890 900
QRKLRVGFAK AGRLMDLMES RNIVGPSEGS KARDVLVKAD ELDGVLAVIR

GEAAP
Length:905
Mass (Da):96,091
Last modified:August 29, 2003 - v2
Checksum:iEC2A47698AF6CFC0
GO

Sequence cautioni

The sequence BAC70221.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70221.1. Different initiation.
RefSeqiWP_052082383.1. NZ_BAVY01000029.1.

Genome annotation databases

EnsemblBacteriaiBAC70221; BAC70221; SAV_2510.
KEGGisma:SAV_2510.
PATRICi23718533. VBIStrAve112782_2684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70221.1. Different initiation.
RefSeqiWP_052082383.1. NZ_BAVY01000029.1.

3D structure databases

ProteinModelPortaliQ82K93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_2510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC70221; BAC70221; SAV_2510.
KEGGisma:SAV_2510.
PATRICi23718533. VBIStrAve112782_2684.

Phylogenomic databases

eggNOGiENOG4107QZI. Bacteria.
COG1674. LUCA.
HOGENOMiHOG000010002.
KOiK03466.
OMAiAEDDHPM.
OrthoDBiEOG6S52GD.

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-2522-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiFTSK_STRAW
AccessioniPrimary (citable) accession number: Q82K93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: December 9, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.