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Protein

Ribonuclease 3

Gene

rnc

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60MagnesiumUniRule annotation1
Active sitei64UniRule annotation1
Metal bindingi133MagnesiumUniRule annotation1
Active sitei136UniRule annotation1
Metal bindingi136MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciSAVE227882:G1G23-2817-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:SAV_2665
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002285941 – 276Ribonuclease 3Add BLAST276

Proteomic databases

PRIDEiQ82JT9

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_2665

Structurei

3D structure databases

ProteinModelPortaliQ82JT9
SMRiQ82JT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 147RNase IIIUniRule annotationAdd BLAST129
Domaini174 – 242DRBMUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q82JT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAKADSTA KKKADNTASS HTLLEGRLGY KLESALLVRA LTHRSYAYEN
60 70 80 90 100
GGLPTNERLE FLGDSVLGLV VTDTLYRTHP DLPEGQLAKL RAAVVNSRAL
110 120 130 140 150
AEVGRGLELG SFIRLGRGEE GTGGRDKASI LADTLEAVIG AVYLDQGLEA
160 170 180 190 200
AGELVHRLFD PLIEKSSNLG AGLDWKTSLQ ELTATEGLGV PEYLVTETGP
210 220 230 240 250
DHEKTFTAAA RVGGVSYGTG TGRSKKEAEQ QAAESAWRAI RSAADERAKA
260 270
AAQAAQTAAE AAERAQGNAD ASSASA
Length:276
Mass (Da):28,923
Last modified:June 1, 2003 - v1
Checksum:i8BD051A9484BDA27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC70376.1
RefSeqiWP_010984099.1, NZ_JZJK01000071.1

Genome annotation databases

EnsemblBacteriaiBAC70376; BAC70376; SAVERM_2665
KEGGisma:SAVERM_2665

Similar proteinsi

Entry informationi

Entry nameiRNC_STRAW
AccessioniPrimary (citable) accession number: Q82JT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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