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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071.

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:SAV_2682
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987151 – 2162-phospho-L-lactate guanylyltransferaseAdd BLAST216

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_2682.

Structurei

3D structure databases

ProteinModelPortaliQ82JS2.
SMRiQ82JS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ME0. Bacteria.
COG1920. LUCA.
HOGENOMiHOG000223639.
OMAiAMLVDTI.
OrthoDBiPOG091H0B3J.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02114. CofC. 1 hit.
InterProiView protein in InterPro
IPR002835. Coenzyme_F420_CofC.
IPR025877. MobA-like_NTP_Trfase.
IPR029044. Nucleotide-diphossugar_trans.
PANTHERiPTHR40392. PTHR40392. 1 hit.
PfamiView protein in Pfam
PF12804. NTP_transf_3. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR03552. F420_cofC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82JS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWTLVVPLK ALARAKSRLA DTAGDGLRPG LALAFAQDTV AAALASAAVR
60 70 80 90 100
DVAVVTGDPV AGRELAALGA RIVADEPAGG LNAALAHAAA VVRSGRPDSG
110 120 130 140 150
VAALNADLPA LRPAELARVL EAAVEFPRAF LPDAAAIGTT LLAAAPGREL
160 170 180 190 200
LPAFGTDSRA RHRASGAVEL GLGGVNSVRQ DVDTGADLRA ALALGVGPRT
210
AAAAARLLIP GPQGDR
Length:216
Mass (Da):21,497
Last modified:June 1, 2003 - v1
Checksum:i7F3462EC4D3FDA5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70393.1.
RefSeqiWP_010984114.1. NZ_JZJK01000071.1.

Genome annotation databases

EnsemblBacteriaiBAC70393; BAC70393; SAVERM_2682.

Similar proteinsi

Entry informationi

Entry nameiCOFC_STRAW
AccessioniPrimary (citable) accession number: Q82JS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: June 1, 2003
Last modified: January 31, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families