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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciSAVE227882:G1G23-2982-MONOMER
UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:SAV_2823
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055521 – 696Phosphate acetyltransferaseAdd BLAST696

Proteomic databases

PRIDEiQ82JD2

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_2823

Structurei

3D structure databases

ProteinModelPortaliQ82JD2
SMRiQ82JD2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni367 – 696Phosphate acetyltransferaseAdd BLAST330

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4105C6K Bacteria
COG0280 LUCA
COG0857 LUCA
HOGENOMiHOG000053797
KOiK13788
OMAiTPLMFEY
OrthoDBiPOG091H01MW

Family and domain databases

Gene3Di3.40.1390.20, 1 hit
InterProiView protein in InterPro
IPR010766 DRTGG
IPR016475 P-Actrans_bac
IPR027417 P-loop_NTPase
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
IPR028979 Ser_kin/Pase_Hpr-like_N_sf
PfamiView protein in Pfam
PF07085 DRTGG, 1 hit
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF006107 PhpActrans_proteobac, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75138 SSF75138, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q82JD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSVYVTGI DRGDGRQVVE LGVMELLTRQ VDRVGVFRPL VHDGPDRLFE
60 70 80 90 100
LLRARYRLAQ DPATVYGMDY HEASALQAEQ GTDELMSTLV DRFHLVARDY
110 120 130 140 150
DVVLVLGTDF ADTQFPDELA LNARLANEFG AAVIPVVGGR GQTAESVRAE
160 170 180 190 200
TRNAYRAYEG LGCDVLAMVV NRVAREDREE LAARLDSLLA VPCYVLPDEP
210 220 230 240 250
ALSAPTVAQI THALGGKVLL GDDSGLARDA LDFVFGGAML PNFLNALTPG
260 270 280 290 300
CLVVTPGDRA DLVVGALAAH SAGTPPIAGV LLTLDERPSD EVLTLAARLA
310 320 330 340 350
PGTPVVSVAG TSFPTAAELF SLEGKLNAAT PRKAETALGL FERYVDTGDL
360 370 380 390 400
LKRVSAPSSD RLTPMMFEHK LLEQARSDKR RVVLPEGTET RVLHAAEVLL
410 420 430 440 450
RRGVCDLTLL GPVDQIRKKA ADLGIDLGGS QLIDPVTSQL RDSFAEKYAQ
460 470 480 490 500
LRAHKGVSVE LAYDVVADVN YFGTLMVQEG LADGMVSGSV HSTAATIRPA
510 520 530 540 550
FEIIKTKPDT KIVSSVFFMC LADKVLVYGD CAVNPDPNAE QLCDIAVQSA
560 570 580 590 600
ATARQFGVEP RIAMLSYSTG TSGSGADVDK VREATELVRL RRDDLKIEGP
610 620 630 640 650
IQYDAAVEPS VAATKLPGSD VAGQASVLIF PDLNTGNNTY KAVQRSAGAI
660 670 680 690
AVGPVMQGLR KPVNDLSRGA LVQDIVNTVA ITAIQAQSPH EKATAQ
Length:696
Mass (Da):74,275
Last modified:June 1, 2003 - v1
Checksum:i211801F5C781E0CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC70534.1
RefSeqiWP_010984255.1, NZ_JZJK01000041.1

Genome annotation databases

EnsemblBacteriaiBAC70534; BAC70534; SAVERM_2823
KEGGisma:SAVERM_2823

Similar proteinsi

Entry informationi

Entry nameiPTA_STRAW
AccessioniPrimary (citable) accession number: Q82JD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health