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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphate acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-2844-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:SAV_2823
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Phosphate acetyltransferasePRO_0000405552Add
BLAST

Proteomic databases

PRIDEiQ82JD2.

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_2823.

Structurei

3D structure databases

ProteinModelPortaliQ82JD2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni367 – 696330Phosphate acetyltransferaseAdd
BLAST

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiVTPLMFE.
OrthoDBiEOG6BKJ5W.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82JD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRSVYVTGI DRGDGRQVVE LGVMELLTRQ VDRVGVFRPL VHDGPDRLFE
60 70 80 90 100
LLRARYRLAQ DPATVYGMDY HEASALQAEQ GTDELMSTLV DRFHLVARDY
110 120 130 140 150
DVVLVLGTDF ADTQFPDELA LNARLANEFG AAVIPVVGGR GQTAESVRAE
160 170 180 190 200
TRNAYRAYEG LGCDVLAMVV NRVAREDREE LAARLDSLLA VPCYVLPDEP
210 220 230 240 250
ALSAPTVAQI THALGGKVLL GDDSGLARDA LDFVFGGAML PNFLNALTPG
260 270 280 290 300
CLVVTPGDRA DLVVGALAAH SAGTPPIAGV LLTLDERPSD EVLTLAARLA
310 320 330 340 350
PGTPVVSVAG TSFPTAAELF SLEGKLNAAT PRKAETALGL FERYVDTGDL
360 370 380 390 400
LKRVSAPSSD RLTPMMFEHK LLEQARSDKR RVVLPEGTET RVLHAAEVLL
410 420 430 440 450
RRGVCDLTLL GPVDQIRKKA ADLGIDLGGS QLIDPVTSQL RDSFAEKYAQ
460 470 480 490 500
LRAHKGVSVE LAYDVVADVN YFGTLMVQEG LADGMVSGSV HSTAATIRPA
510 520 530 540 550
FEIIKTKPDT KIVSSVFFMC LADKVLVYGD CAVNPDPNAE QLCDIAVQSA
560 570 580 590 600
ATARQFGVEP RIAMLSYSTG TSGSGADVDK VREATELVRL RRDDLKIEGP
610 620 630 640 650
IQYDAAVEPS VAATKLPGSD VAGQASVLIF PDLNTGNNTY KAVQRSAGAI
660 670 680 690
AVGPVMQGLR KPVNDLSRGA LVQDIVNTVA ITAIQAQSPH EKATAQ
Length:696
Mass (Da):74,275
Last modified:June 1, 2003 - v1
Checksum:i211801F5C781E0CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70534.1.
RefSeqiNP_823999.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC70534; BAC70534; SAV_2823.
GeneIDi1210558.
KEGGisma:SAV_2823.
PATRICi23719227. VBIStrAve112782_3023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70534.1.
RefSeqiNP_823999.1. NC_003155.4.

3D structure databases

ProteinModelPortaliQ82JD2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_2823.

Proteomic databases

PRIDEiQ82JD2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC70534; BAC70534; SAV_2823.
GeneIDi1210558.
KEGGisma:SAV_2823.
PATRICi23719227. VBIStrAve112782_3023.

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiVTPLMFE.
OrthoDBiEOG6BKJ5W.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciSAVE227882:GJU1-2844-MONOMER.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiPTA_STRAW
AccessioniPrimary (citable) accession number: Q82JD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: June 1, 2003
Last modified: March 4, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.