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Protein
Submitted name:

Putative 2-oxoglutarate dehydrogenase

Gene

sucA

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  2. thiamine pyrophosphate binding Source: InterPro
  3. transferase activity, transferring acyl groups Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-2994-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative 2-oxoglutarate dehydrogenaseImported
Gene namesi
Name:sucAImported
Ordered Locus Names:SAV_2972Imported
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)Imported
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_2972.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000259587.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR001078. 2-oxoacid_DH_actylTfrase.
IPR011603. 2oxoglutarate_DH_E1.
IPR023213. CAT-like_dom.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82J10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPQSPSNSS ISTDDQAGKN PAAAFGPNEW LVDEIYQQYL QDPNSVDRAW
60 70 80 90 100
WDFFADYKPG AAAASAPAGT AAAGAAETTT PAPAAPTAAA PAAPAAPAPA
110 120 130 140 150
APAPAPAAPA PAAAPAVPKP AAAAPAPAAA KPAAAAPAQP KAAAATEAAE
160 170 180 190 200
GPTFVPLRGP AAAVAKNMNA SIEVPTATSV RAVPVKLLFD NRIVINNHLK
210 220 230 240 250
RARGGKISFT HLIGYAMVQA IKAMPSMNWH YAEKDGKPTL VKPAHVNFGL
260 270 280 290 300
AIDLVKPNGD RQLVVAGIKK AETLNFFEFW QAYEDIVRRA RDGKLTMDDF
310 320 330 340 350
TGVTVSLTNP GGLGTVHSVP RLMPGQSVIM GVGSMDYPAE FQGTSQDTLN
360 370 380 390 400
KLGISKVMTL TSTYDHRVIQ GAASGEFLRI VANFLLGEGG FYDEIFEALR
410 420 430 440 450
IPYEPVRWLK DIDASHDDDV TKAARVFELI HSYRVRGHVM ADTDPLEYRQ
460 470 480 490 500
RKHPDLDITE HGLTLWDLER EFAVGGFAGK SLMKLRDILG VLRDSYCRTT
510 520 530 540 550
GIEFMHIQDP KQRKWIQDRI ERSHSKPERE EQLRILRRLN AAEAFETFLQ
560 570 580 590 600
TKYVGQKRFS LEGGESVIPL LDAVIDSAAE SRLDEVVIGM AHRGRLNVLA
610 620 630 640 650
NIVGKSYAQI FREFEGNLDP KSMHGSGDVK YHLGASGTFT GLDGEQIKVS
660 670 680 690 700
LAANPSHLET VDPIIEGIAR AKQDIINKGG TDFTVLPVAL HGDAAFAGQG
710 720 730 740 750
VVAETLNMSQ LRGYRTGGTV HIVINNQVGF TAAPESSRSS MYATDVARMI
760 770 780 790 800
EAPIFHVNGD DPEAVVRVAR LAFEFRQAFN KDVVIDLICY RRRGHNESDN
810 820 830 840 850
PAFTQPLMYD LIDKKRSVRK LYTESLIGRG DITLEEAEQA LQDFQGQLEK
860 870 880 890 900
VFTEVREAIS TPGEAPAPEP QPEFPVAVPT AVSQEVVKRI AESQVNIPDH
910 920 930 940 950
VTVHPRLLPQ LQRRAAMIED DTIDWGMGET LAIGSLLLEG TPVRLSGQDS
960 970 980 990 1000
RRGTFGQRHA VLIDRVTGED FTPLQYLADD QARLNVYDSL LSEYAVMGFE
1010 1020 1030 1040 1050
YGYSLARPDA LVMWEAQFGD FVNGAQTVVD EYISAAEQKW GQTSGVTLLL
1060 1070 1080 1090 1100
PHGYEGQGPD HSSARIERFL QLCAQNNMTV AQPTLPSNYF HLLRWQVHNP
1110 1120 1130 1140 1150
HHKPLVVFTP KSMLRLKAAA SKTEEFTTGA FRPVIGDDTV DAAAVRKVVF
1160 1170 1180 1190 1200
CAGKLYYDLE AERKKRGATD AAAAETAIIR LERLYPLPGA ELQAEIAKYP
1210 1220 1230 1240 1250
NAEKYLWAQE EPANQGAWPF IALNLIDHLD LAVGADVPHG ERLRRISRPH
1260 1270
SSSPAVGSAK RHQAEQEQLV REVFEA
Length:1,276
Mass (Da):139,178
Last modified:May 31, 2003 - v1
Checksum:i13CC421F7081926D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70683.1.
RefSeqiNP_824148.1. NC_003155.4.
WP_010984404.1. NZ_BAVY01000023.1.

Genome annotation databases

EnsemblBacteriaiBAC70683; BAC70683; SAV_2972.
KEGGisma:SAV_2972.
PATRICi23719541. VBIStrAve112782_3179.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70683.1.
RefSeqiNP_824148.1. NC_003155.4.
WP_010984404.1. NZ_BAVY01000023.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_2972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC70683; BAC70683; SAV_2972.
KEGGisma:SAV_2972.
PATRICi23719541. VBIStrAve112782_3179.

Phylogenomic databases

HOGENOMiHOG000259587.
KOiK00164.
OMAiQNQGAWF.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-2994-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
3.40.50.970. 2 hits.
InterProiIPR001078. 2-oxoacid_DH_actylTfrase.
IPR011603. 2oxoglutarate_DH_E1.
IPR023213. CAT-like_dom.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680Imported.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiQ82J10_STRAW
AccessioniPrimary (citable) accession number: Q82J10
Entry historyi
Integrated into UniProtKB/TrEMBL: May 31, 2003
Last sequence update: May 31, 2003
Last modified: March 31, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.