Q82IE7 (EX7L_STRAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Exodeoxyribonuclease 7 large subunit
EC=3.1.11.6

Alternative name(s):
Exodeoxyribonuclease VII large subunit
Short name=Exonuclease VII large subunit

Gene names

Name:	xseA
Ordered Locus Names:	SAV_3211

Organism

Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) [Complete proteome] [HAMAP]

Taxonomic identifier

227882 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces avermitilis

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. HAMAP-Rule MF_00378
Catalytic activity	Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00378
Subunit structure	Heterooligomer composed of large and small subunits By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the XseA family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Exonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA catabolic process Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell exodeoxyribonuclease VII complex Inferred from electronic annotation. Source: InterPro
Molecular_function	exodeoxyribonuclease VII activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Exodeoxyribonuclease 7 large subunit HAMAP-Rule MF_00378		PRO_0000303827

Sequences

	Sequence		Length	Mass (Da)
	Q82IE7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 863AB19C4C8F4A07	FASTA	402	43,844
	10 20 30 40 50 60 MAANTSAETP LPVGEVSRLI GGWIDRLGAV WVEGQITQLS RRPGAGVVFM TLRDPSYDIS 70 80 90 100 110 120 VGVTCYRQVF DAVADVVSEG ARVVVHAKPE WYAPRGQLSL RAAEIRPIGV GELLARLEQL 130 140 150 160 170 180 KKSLAGEGLF VTERKKALPF LPQLIGLVCG RASAAERDVL ENARHRWPAV RFEVRNVAVQ 190 200 210 220 230 240 GVHAVPQVVQ AVKELDARDD VDVIIVARGG GSVEDLLPFS DEQLVRAVAA CRTPVVSAIG 250 260 270 280 290 300 HEPDTPLLDY VADLRASTPT DAAKKVVPDV GEEVERVRAL RDRARRCVRS VIEREERGLA 310 320 330 340 350 360 HTLARPSIED PHRMVDERAD QVASLLDRGR RTLGHLLDRA DSELSHTHAR VVALSPAATL 370 380 390 400 KRGYAVLQRA DGHAVRAPDE VTADEVLRAR VAEGEFTVRV DV

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000030 Genomic DNA. Translation: BAC70922.1.
RefSeq	NP_824387.1. NC_003155.4.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	227882.SAV_3211.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC70922; BAC70922; SAV_3211.
GeneID	1210689.
KEGG	sma:SAV_3211.
PATRIC	23720049. VBIStrAve112782_3431.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1570.
HOGENOM	HOG000229264.
KO	K03601.
OMA	ENAQVRC.
ProtClustDB	PRK00286.
Enzyme and pathway databases
BioCyc	SAVE227882:GJU1-3235-MONOMER.
Family and domain databases
HAMAP	MF_00378. Exonuc_7_L.
InterPro	IPR003753. Exonuc_VII_L. IPR020579. Exonuc_VII_lsu_C. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Pfam	PF02601. Exonuc_VII_L. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
TIGRFAMs	TIGR00237. xseA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

EX7L_STRAW

Accession

Primary (citable) accession number: Q82IE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program