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Q82IE7 (EX7L_STRAW) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exodeoxyribonuclease 7 large subunit

EC=3.1.11.6
Alternative name(s):
Exodeoxyribonuclease VII large subunit
Short name=Exonuclease VII large subunit
Gene names
Name:xseA
Ordered Locus Names:SAV_3211
OrganismStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) [Complete proteome] [HAMAP]
Taxonomic identifier227882 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides By similarity. HAMAP-Rule MF_00378

Catalytic activity

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. HAMAP-Rule MF_00378

Subunit structure

Heterooligomer composed of large and small subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00378.

Sequence similarities

Belongs to the XseA family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionExonuclease
Hydrolase
Nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

exodeoxyribonuclease VII complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionexodeoxyribonuclease VII activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 402402Exodeoxyribonuclease 7 large subunit HAMAP-Rule MF_00378
PRO_0000303827

Sequences

Sequence LengthMass (Da)Tools
Q82IE7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 863AB19C4C8F4A07

FASTA40243,844
        10         20         30         40         50         60 
MAANTSAETP LPVGEVSRLI GGWIDRLGAV WVEGQITQLS RRPGAGVVFM TLRDPSYDIS 

        70         80         90        100        110        120 
VGVTCYRQVF DAVADVVSEG ARVVVHAKPE WYAPRGQLSL RAAEIRPIGV GELLARLEQL 

       130        140        150        160        170        180 
KKSLAGEGLF VTERKKALPF LPQLIGLVCG RASAAERDVL ENARHRWPAV RFEVRNVAVQ 

       190        200        210        220        230        240 
GVHAVPQVVQ AVKELDARDD VDVIIVARGG GSVEDLLPFS DEQLVRAVAA CRTPVVSAIG 

       250        260        270        280        290        300 
HEPDTPLLDY VADLRASTPT DAAKKVVPDV GEEVERVRAL RDRARRCVRS VIEREERGLA 

       310        320        330        340        350        360 
HTLARPSIED PHRMVDERAD QVASLLDRGR RTLGHLLDRA DSELSHTHAR VVALSPAATL 

       370        380        390        400 
KRGYAVLQRA DGHAVRAPDE VTADEVLRAR VAEGEFTVRV DV 

« Hide

References

[1]"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
[2]"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000030 Genomic DNA. Translation: BAC70922.1.
RefSeqNP_824387.1. NC_003155.4.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227882.SAV_3211.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC70922; BAC70922; SAV_3211.
GeneID1210689.
KEGGsma:SAV_3211.
PATRIC23720049. VBIStrAve112782_3431.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1570.
HOGENOMHOG000229264.
KOK03601.
OMAENAQVRC.
OrthoDBEOG64R65J.
ProtClustDBPRK00286.

Enzyme and pathway databases

BioCycSAVE227882:GJU1-3235-MONOMER.

Family and domain databases

HAMAPMF_00378. Exonuc_7_L.
InterProIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PfamPF02601. Exonuc_VII_L. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
TIGRFAMsTIGR00237. xseA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameEX7L_STRAW
AccessionPrimary (citable) accession number: Q82IE7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families