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Q82IE7

- EX7L_STRAW

UniProt

Q82IE7 - EX7L_STRAW

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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

  1. exodeoxyribonuclease VII activity Source: UniProtKB-HAMAP
  2. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-3235-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:SAV_3211
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
  2. exodeoxyribonuclease VII complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Exodeoxyribonuclease 7 large subunitPRO_0000303827Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_3211.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1570.
HOGENOMiHOG000229264.
KOiK03601.
OMAiWIEGQIV.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82IE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANTSAETP LPVGEVSRLI GGWIDRLGAV WVEGQITQLS RRPGAGVVFM
60 70 80 90 100
TLRDPSYDIS VGVTCYRQVF DAVADVVSEG ARVVVHAKPE WYAPRGQLSL
110 120 130 140 150
RAAEIRPIGV GELLARLEQL KKSLAGEGLF VTERKKALPF LPQLIGLVCG
160 170 180 190 200
RASAAERDVL ENARHRWPAV RFEVRNVAVQ GVHAVPQVVQ AVKELDARDD
210 220 230 240 250
VDVIIVARGG GSVEDLLPFS DEQLVRAVAA CRTPVVSAIG HEPDTPLLDY
260 270 280 290 300
VADLRASTPT DAAKKVVPDV GEEVERVRAL RDRARRCVRS VIEREERGLA
310 320 330 340 350
HTLARPSIED PHRMVDERAD QVASLLDRGR RTLGHLLDRA DSELSHTHAR
360 370 380 390 400
VVALSPAATL KRGYAVLQRA DGHAVRAPDE VTADEVLRAR VAEGEFTVRV

DV
Length:402
Mass (Da):43,844
Last modified:June 1, 2003 - v1
Checksum:i863AB19C4C8F4A07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70922.1.
RefSeqiNP_824387.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC70922; BAC70922; SAV_3211.
GeneIDi1210689.
KEGGisma:SAV_3211.
PATRICi23720049. VBIStrAve112782_3431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70922.1 .
RefSeqi NP_824387.1. NC_003155.4.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227882.SAV_3211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC70922 ; BAC70922 ; SAV_3211 .
GeneIDi 1210689.
KEGGi sma:SAV_3211.
PATRICi 23720049. VBIStrAve112782_3431.

Phylogenomic databases

eggNOGi COG1570.
HOGENOMi HOG000229264.
KOi K03601.
OMAi WIEGQIV.
OrthoDBi EOG64R65J.

Enzyme and pathway databases

BioCyci SAVE227882:GJU1-3235-MONOMER.

Family and domain databases

HAMAPi MF_00378. Exonuc_7_L.
InterProi IPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR004365. NA-bd_OB_tRNA.
[Graphical view ]
Pfami PF02601. Exonuc_VII_L. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00237. xseA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiEX7L_STRAW
AccessioniPrimary (citable) accession number: Q82IE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3