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Protein

Exodeoxyribonuclease 7 small subunit

Gene

xseB

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-3236-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 small subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII small subunitUniRule annotation
Short name:
Exonuclease VII small subunitUniRule annotation
Gene namesi
Name:xseBUniRule annotation
Ordered Locus Names:SAV_3212
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8080Exodeoxyribonuclease 7 small subunitPRO_0000207013Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_3212.

Structurei

3D structure databases

ProteinModelPortaliQ82IE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the XseB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105YX8. Bacteria.
COG1722. LUCA.
HOGENOMiHOG000228798.
KOiK03602.
OMAiLPHESAD.
OrthoDBiEOG69KV31.

Family and domain databases

Gene3Di1.10.287.1040. 1 hit.
HAMAPiMF_00337. Exonuc_7_S.
InterProiIPR003761. Exonuc_VII_S.
[Graphical view]
PfamiPF02609. Exonuc_VII_S. 1 hit.
[Graphical view]
PIRSFiPIRSF006488. Exonuc_VII_S. 1 hit.
ProDomiPD028235. Exonuc_VII_S. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01280. xseB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82IE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRTDETAN ATALGYEQAR DELIEVVRRL EAGGTTLEES LALWERGEEL
60 70 80
AKVCRTWLEG ARKRLDAALA EEENAGDDSE
Length:80
Mass (Da):8,869
Last modified:June 1, 2003 - v1
Checksum:iDD549EBA5B8C7E54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70923.1.
RefSeqiWP_010984642.1. NZ_JZJK01000090.1.

Genome annotation databases

EnsemblBacteriaiBAC70923; BAC70923; SAV_3212.
KEGGisma:SAV_3212.
PATRICi23720051. VBIStrAve112782_3432.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC70923.1.
RefSeqiWP_010984642.1. NZ_JZJK01000090.1.

3D structure databases

ProteinModelPortaliQ82IE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_3212.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC70923; BAC70923; SAV_3212.
KEGGisma:SAV_3212.
PATRICi23720051. VBIStrAve112782_3432.

Phylogenomic databases

eggNOGiENOG4105YX8. Bacteria.
COG1722. LUCA.
HOGENOMiHOG000228798.
KOiK03602.
OMAiLPHESAD.
OrthoDBiEOG69KV31.

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-3236-MONOMER.

Family and domain databases

Gene3Di1.10.287.1040. 1 hit.
HAMAPiMF_00337. Exonuc_7_S.
InterProiIPR003761. Exonuc_VII_S.
[Graphical view]
PfamiPF02609. Exonuc_VII_S. 1 hit.
[Graphical view]
PIRSFiPIRSF006488. Exonuc_VII_S. 1 hit.
ProDomiPD028235. Exonuc_VII_S. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01280. xseB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiEX7S_STRAW
AccessioniPrimary (citable) accession number: Q82IE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: December 9, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.