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Protein

Tryptophan--tRNA ligase 2

Gene

trpS2

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei139L-tryptophanUniRule annotation1
Binding sitei190ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 15ATPUniRule annotation3
Nucleotide bindingi22 – 23ATPUniRule annotation2
Nucleotide bindingi151 – 153ATPUniRule annotation3
Nucleotide bindingi199 – 203ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAVE227882:G1G23-3592-MONOMER
BRENDAi6.1.1.2 5980

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase 2UniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetase 2UniRule annotation
Short name:
TrpRS 2UniRule annotation
Gene namesi
Name:trpS2UniRule annotation
Ordered Locus Names:SAV_3417
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366851 – 337Tryptophan--tRNA ligase 2Add BLAST337

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_3417

Structurei

3D structure databases

ProteinModelPortaliQ82HU1
SMRiQ82HU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi14 – 23"HIGH" regionUniRule annotation10
Motifi199 – 203"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q82HU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASDRPRVLS GIQPTAGSFH LGNYLGAVRQ WVALQESHDA FYMVVDLHAI
60 70 80 90 100
TVPQDPADLR ANTRLAAAQL LAAGLDPERC TLFVQSHVPE HAQLAWIMNC
110 120 130 140 150
LTGFGEASRM TQFKDKSAKQ GADRASVGLF TYPVLQVADI LLYQANEVPV
160 170 180 190 200
GEDQRQHIEL TRDLAERFNG RFGETFTVPK PYILKETAKI FDLQDPSIKM
210 220 230 240 250
SKSASTPKGL INLLDEPKAT AKKVKSAVTD TDTVIRYDAE HKPGISNLLT
260 270 280 290 300
IYSTLTGTGI PELEEKYTGK GYGALKTDLA EVMVDFVTPF RERTQQYLDD
310 320 330
PETLDSILAK GAEKARAVAA ETLSQAYDRV GFLPAKH
Length:337
Mass (Da):37,096
Last modified:June 1, 2003 - v1
Checksum:i23DAF4D121131864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC71129.1
RefSeqiWP_010984848.1, NZ_JZJK01000090.1

Genome annotation databases

EnsemblBacteriaiBAC71129; BAC71129; SAVERM_3417
KEGGisma:SAVERM_3417

Similar proteinsi

Entry informationi

Entry nameiSYW2_STRAW
AccessioniPrimary (citable) accession number: Q82HU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health