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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei136 – 1361UniRule annotation
Active sitei568 – 5681UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-3593-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:SAV_3566
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
ProteomesiUP000000428 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Phosphoenolpyruvate carboxylasePRO_0000166627Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_3566.

Structurei

3D structure databases

ProteinModelPortaliQ82HE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiWGFAVIE.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82HE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSADDQTTT TSSELRADIR RLGDLLGETL VRQEGPELLD LVEKVRRLTR
60 70 80 90 100
EDGEAAAELL RGTELETAAK LVRAFSTYFH LANVTEQVHR GRELRTKRAA
110 120 130 140 150
EGGLLARTAD RLKDADPEHL RATVKNLNVR PVFTAHPTEA ARRSVLNKLR
160 170 180 190 200
RIAALLETPV IEADRRRYDT RLAENIDLVW QTDELRVVRP EPADEARNAI
210 220 230 240 250
YYLDELHAGA VGDVLEDLTA ELERVGVQLP DDTRPLTFGT WIGGDRDGNP
260 270 280 290 300
NVTPEVTWDV LILQHEHGIN DALELIDELR GFLSNSIRYT GATEELLTSL
310 320 330 340 350
GTDLERLPEI SPRYKRLNAE EPYRLKATCI RQKLENTKQR LAKGTAHQPG
360 370 380 390 400
RDYLGTGELL HDLKLIQTSL REHRGGLFAD GRMDRTIRTL AAFGLQLATM
410 420 430 440 450
DVREHADAHH YALGQLFDRL GEESWRYADM PRDYRGKLLA KELRSRRPLA
460 470 480 490 500
PSPAPLDAAG AKTLGVFHTV KRALAVFGPE VIESYIISMC QGADDVFAAA
510 520 530 540 550
VLAREAGLLD LHAGWAKIGI VPLLETTDEL KAADTILEDM LSDPSYRRLV
560 570 580 590 600
ALRGDVQEVM LGYSDSSKFG GITTSQWEIH RAQRRLRDVA HRYGVRLRLF
610 620 630 640 650
HGRGGTVGRG GGPSHDAILA QPWGTLEGEI KVTEQGEVIS DKYLVPSLAR
660 670 680 690 700
ENLELTVAAT LQASALHTAP RQSDEALARW DAAMDVVSDA AHSAYRRLVE
710 720 730 740 750
DPDLPTYFLA STPVDQLADL HLGSRPSRRP GSGVSLDGLR AIPWVFGWTQ
760 770 780 790 800
SRQIVPGWFG VGSGLKALRE AGLDTVLDEM HEQWHFFRNF LSNVEMTLAK
810 820 830 840 850
TDLRIARHYV DTLVPDHLKH VFATIEAEHE LTVREVLRIT GGEKLLDTHP
860 870 880 890 900
VLQQTFAIRD AYLDPISYLQ VALLKRQRDA AAADTPPDPL LARALLLTVN
910
GVAAGLRNTG
Length:910
Mass (Da):101,200
Last modified:June 1, 2003 - v1
Checksum:iD327E1B9D164403D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC71278.1.
RefSeqiWP_010984997.1. NZ_BAVY01000013.1.

Genome annotation databases

EnsemblBacteriaiBAC71278; BAC71278; SAV_3566.
KEGGisma:SAV_3566.
PATRICi23720817. VBIStrAve112782_3813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC71278.1.
RefSeqiWP_010984997.1. NZ_BAVY01000013.1.

3D structure databases

ProteinModelPortaliQ82HE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_3566.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC71278; BAC71278; SAV_3566.
KEGGisma:SAV_3566.
PATRICi23720817. VBIStrAve112782_3813.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiWGFAVIE.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-3593-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiCAPP_STRAW
AccessioniPrimary (citable) accession number: Q82HE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.