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Protein

Glutamate decarboxylase

Gene

gadB1

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadB1Imported
ORF Names:SAVERM_3601Imported
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)Imported
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei265N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_3601.

Structurei

3D structure databases

ProteinModelPortaliQ82HA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CVK. Bacteria.
COG0076. LUCA.
HOGENOMiHOG000070228.
KOiK01580.
OMAiLHCSTFA.
OrthoDBiPOG091H06F5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82HA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKRDVAALF GNRFLTEPAP SQTFPEEGMT ATDTMRLLDE DLVMEGDPQR
60 70 80 90 100
NLATFVTTWM EPEAQRIIAE NLHRNFIDHA EYPISAEIEQ RCVRMLADLF
110 120 130 140 150
HAPGKTTGCR TQGSSEAIML GALSLKWKWR ERRQAANLPA DRPNLVFGGD
160 170 180 190 200
VHVVWEKFCR YFDVEPRIVP LAEDKYTIGP EDVEPHIDEN TIGVVAVVGT
210 220 230 240 250
TFTGHKDDVV GIDKLLRDVR KERDLDIPIH VDGASGGFVW PFLYPDSKWD
260 270 280 290 300
FRLEQVRSIN VSGHKYGLVY PGIGWLVFRE ESDLAKDLVF YENYLGKTDA
310 320 330 340 350
TFTLNFSTGA SMVLAQYYNF VRLGRQGYTY VMETMQKNAH ALADNLRSSG
360 370 380 390 400
RFEVIGSDLE QLPLVAFRLA GEHAYDESDI AWQLSAERGW MVPAYTLPPN
410 420 430 440 450
AERVKILRAL VKETLSREQI ERLTQDIADA CATLDHKGGT TEVERAQIKR

GTGY
Length:454
Mass (Da):51,371
Last modified:June 1, 2003 - v1
Checksum:iC00B49C1EEA62442
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC71313.1.
RefSeqiWP_010985032.1. NZ_JZJK01000090.1.

Genome annotation databases

EnsemblBacteriaiBAC71313; BAC71313; SAVERM_3601.
KEGGisma:SAV_3601.
PATRICi23720887. VBIStrAve112782_3848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC71313.1.
RefSeqiWP_010985032.1. NZ_JZJK01000090.1.

3D structure databases

ProteinModelPortaliQ82HA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_3601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC71313; BAC71313; SAVERM_3601.
KEGGisma:SAV_3601.
PATRICi23720887. VBIStrAve112782_3848.

Phylogenomic databases

eggNOGiENOG4105CVK. Bacteria.
COG0076. LUCA.
HOGENOMiHOG000070228.
KOiK01580.
OMAiLHCSTFA.
OrthoDBiPOG091H06F5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ82HA9_STRAW
AccessioniPrimary (citable) accession number: Q82HA9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.