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Protein

Glutamate decarboxylase

Gene

gadB2

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-4709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadB2Imported
Ordered Locus Names:SAV_4655Imported
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)Imported
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_4655.

Structurei

3D structure databases

ProteinModelPortaliQ82EG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82EG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHKGPVKS DERPMSFNPF FGEANPVSGM TEAPPKHRLA DGPLPPSTAY
60 70 80 90 100
QLVHDELMLD GNARLNLATF VTTWMEPQAG VLMAECQDKN MIDKDEYPRT
110 120 130 140 150
AELEKRCVAM LADLWNAPDA GAAVGCSTTG SSEACMLAGL ALKRRWARRN
160 170 180 190 200
ADRYPARDVR PNLVMGINVQ VCWEKFCNFW EVEMRQVPLE GERYHLDPGA
210 220 230 240 250
AAELCDENTI GVVGILGSTF DGSYEPIAEL CAALDALQER TGLDIPVHVD
260 270 280 290 300
GASGAMIAPF LDEDLVWDFR LPRVASINTS GHKYGLVSPG VGWALWRDSE
310 320 330 340 350
ALPEELVFRV NYLGGNMPTF ALNFSRPGAQ VVAQYYTFLR LGREGFRAVQ
360 370 380 390 400
QTTRNVARSL AERVAALGDF HLLTRGDELP VFAFTTAPEV ASYDVFDVSR
410 420 430 440 450
RMREHGWLVP AYTFPPNRED LSVLRVVCRN GFSTDLAELF VEDLSRLLPD
460 470
LRRQARPQTH DKDAATGFHH
Length:470
Mass (Da):52,225
Last modified:June 1, 2003 - v1
Checksum:iD77705B0991C0B1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC72367.1.
RefSeqiNP_825832.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC72367; BAC72367; SAV_4655.
KEGGisma:SAV_4655.
PATRICi23723183. VBIStrAve112782_4970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC72367.1.
RefSeqiNP_825832.1. NC_003155.4.

3D structure databases

ProteinModelPortaliQ82EG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_4655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC72367; BAC72367; SAV_4655.
KEGGisma:SAV_4655.
PATRICi23723183. VBIStrAve112782_4970.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiDPDLVWD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-4709-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680Imported.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiQ82EG0_STRAW
AccessioniPrimary (citable) accession number: Q82EG0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.