Q82EB2 (CSEC_STRAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sensor protein CseC
EC=2.7.13.3

Gene names

Name:	cseC
Ordered Locus Names:	SAV_4703

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Contains 1 HAMP domain. Contains 1 histidine kinase domain.

Ontologies

Keywords
Biological process	Two-component regulatory system
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	Sensor protein CseC		PRO_0000314482
Regions
	Transmembrane	63 – 83	21	Helical; Potential
	Transmembrane	185 – 205	21	Helical; Potential
	Domain	206 – 262	57	HAMP
	Domain	270 – 472	203	Histidine kinase
Amino acid modifications
	Modified residue	273	1	Phosphohistidine; by autocatalysis By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q82EB2 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B5B108F884C3A5EE	FASTA	487	51,616
	10 20 30 40 50 60 MRGNLRRPGP AGTAGPGRTG IRTSADGGRA RPRTGAGTGV RAGVRSGVVG VGAGIRTGVR 70 80 90 100 110 120 WKISAAIALV GALVALALSL VVHNAARVSM LDNARDLADE RIQVAERMYE AGRAQSFGVK 130 140 150 160 170 180 LDDPAIPRDL MMKVTQGRRA TYVADGPHGV PDIWAAVPLK DGRVLSLHTR FTDRSADIMK 190 200 210 220 230 240 DLDQALIIGS IAVVFGGSAL GVLIGGQLSR RLRKAAAAAN QVAQGERDVR VRDAIGGVVR 250 260 270 280 290 300 DETDDLARAV DAMADALQQR IEAERRVTAD IAHELRTPVT GLLTAAELLP PGRPTELVRD 310 320 330 340 350 360 RAQAMRTLVE DVLEVARLDG ASERAELQDI MLGEFVSRRV AAKDADIEVR VVHESEVTTD 370 380 390 400 410 420 PRRLERVLFN LLANAARHGK PPIEVSVEGR VIRVRDHGPG FPEELLADGP RRFRTGSTDR 430 440 450 460 470 480 AGHGHGLGLT IAAGQARVLG ARLTFRNVRP AGAPGDVPAE GAVAVLWLPE HAPTNTGSFP MLPLSGG

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000030 Genomic DNA. Translation: BAC72415.1.
RefSeq	NP_825880.1. NC_003155.4.
3D structure databases
ProteinModelPortal	Q82EB2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1215471.
GenomeReviews	Gene locus SAV_4703 in contig BA000030_GR.
KEGG	sma:SAV_4703.
NMPDR	fig|227882.1.peg.4706.
PATRIC	23723281. VBIStrAve112782_5019.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695485.
OMA	ERRVTAD.
ProtClustDB	CLSK635768.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV4703-MONOMER.
Family and domain databases
InterPro	IPR003594. ATPase-like_ATP-bd. IPR003660. HAMP_linker_domain. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. IPR009082. Sig_transdc_His_kinase_dimeric. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
Pfam	PF00672. HAMP. 1 hit. PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. [Graphical view]
SMART	SM00304. HAMP. 1 hit. SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF47384. His_kin_homodim. 1 hit.
PROSITE	PS50885. HAMP. 1 hit. PS50109. HIS_KIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CSEC_STRAW

Accession

Primary (citable) accession number: Q82EB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program