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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAVE227882:G1G23-5000-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:SAV_4748
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516151 – 590Arginine--tRNA ligaseAdd BLAST590

Proteomic databases

PRIDEiQ82E68

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_4748

Structurei

3D structure databases

ProteinModelPortaliQ82E68
SMRiQ82E68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi126 – 136"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C75 Bacteria
COG0018 LUCA
HOGENOMiHOG000247212
KOiK01887
OMAiALCVFFD
OrthoDBiPOG091H01RF

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q82E68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTSLTAS VHQRLADALS AALPEAGSAD PLLRRSDRAD FQANGILALA
60 70 80 90 100
KKAKANPRDL ATQVVARVES GEVIKDIEVS GPGFLNITIT DQAITRNLAA
110 120 130 140 150
RYEDGERLGV PLAEHPGTTV IDYAQPNVAK EMHVGHLRSA VIGDAVVQIL
160 170 180 190 200
EFTGENVVRR HHIGDWGTQF GMLIQYLIEH PHELDHKGAA EVSGEEAMSN
210 220 230 240 250
LNRLYKAART LFDSDEEFKT RARRRVVDLQ AGEPETLAMW QKFVDESKIY
260 270 280 290 300
FYSVFDKLDL EIRDPDVVGE SGYNDMLDET CRLLEESGVA VRSDGALCVF
310 320 330 340 350
FDDVKGPDGN PVPLIVKKSD GGYGYAATDL SAIRDRVFNL KANSLIYVVD
360 370 380 390 400
ARQSLHFKMV FETARRAGWL NDDVQAQQLA FGTVLGKDGK PFKTREGETI
410 420 430 440 450
RLVDLLDEAI DRATAVVREK AEKVGLSEQE IEENGRYVGI GAVKYADLST
460 470 480 490 500
SAVRDYKFDL DQMVSLNGDT SVYLQYAYAR IRSIFGKAGD RTPLAHPELE
510 520 530 540 550
LAPAERALGL HLDRFGETLD EVAAEYAPHK LAAYLYQLAS LYTTFYDQCP
560 570 580 590
VIKPAPAQEV AENRLFLCDL TARTLHQGMA LLGIRTPERL
Length:590
Mass (Da):65,189
Last modified:June 1, 2003 - v1
Checksum:iC3F7D392CFE690B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC72460.1
RefSeqiWP_010986171.1, NZ_JZJK01000077.1

Genome annotation databases

EnsemblBacteriaiBAC72460; BAC72460; SAVERM_4748
KEGGisma:SAVERM_4748

Similar proteinsi

Entry informationi

Entry nameiSYR_STRAW
AccessioniPrimary (citable) accession number: Q82E68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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