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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSAVE227882:G1G23-5046-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:SAV_4795
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001204581 – 438Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ82E21

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_4795

Structurei

3D structure databases

ProteinModelPortaliQ82E21
SMRiQ82E21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q82E21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACVSYPYEA PVSQTLFERA AAVTPGGVNS PVRAFRAVGG TPRFMVSGNG
60 70 80 90 100
PYLTDADGRT YVDLVCSWGP MILGHSHPEV IAAVQEAVAR GTSFGTPGEG
110 120 130 140 150
EVALAEEIVA RVEPVEQVRL VSSGTEATMS AIRLARGFTR RAKVIKFAGC
160 170 180 190 200
YHGHVDSLLA AAGSGLATFA LPDTPGVTGA QAGDTIVLPY NDLDAVREAF
210 220 230 240 250
RAHPGEIACV ITEASPGNMG VVPPAPGFNQ GLKDACAENG ALYISDEVMT
260 270 280 290 300
GFRTSKAGWY GVDGVRPDLM TFGKVMGGGF PAAAFGGRRD VMAHLAPAGP
310 320 330 340 350
VYQAGTLSGN PVATAAGLAQ LRLLDDAAYA KVDAVSAEIR TLVTDALTKE
360 370 380 390 400
GVAHRLQNAS NMFSVFFTDR PVNNYEDAKG QESFRFTAFF HSLLAQGVYL
410 420 430
PPSSFESWFV STAHDEQAVQ RIADALPAAA RAAAEATA
Length:438
Mass (Da):45,777
Last modified:June 1, 2003 - v1
Checksum:iCEA5ACA680F42BD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA Translation: BAC72507.1
RefSeqiWP_010986218.1, NZ_JZJK01000077.1

Genome annotation databases

EnsemblBacteriaiBAC72507; BAC72507; SAVERM_4795
KEGGisma:SAVERM_4795

Similar proteinsi

Entry informationi

Entry nameiGSA_STRAW
AccessioniPrimary (citable) accession number: Q82E21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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