Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent Clp protease proteolytic subunit 3

Gene

clpP3

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.UniRule annotation

Catalytic activityi

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei112NucleophileUniRule annotation1
Active sitei137UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS14.008.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunit 3UniRule annotation (EC:3.4.21.92UniRule annotation)
Alternative name(s):
Endopeptidase Clp 3UniRule annotation
Gene namesi
Name:clpP3UniRule annotation
Ordered Locus Names:SAV_5447
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001796611 – 219ATP-dependent Clp protease proteolytic subunit 3Add BLAST219

Interactioni

Subunit structurei

Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

Protein-protein interaction databases

STRINGi227882.SAV_5447.

Structurei

3D structure databases

ProteinModelPortaliQ82CA6.
SMRiQ82CA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CCQ. Bacteria.
COG0740. LUCA.
HOGENOMiHOG000285833.
KOiK01358.
OMAiANKRNVI.
OrthoDBiPOG091H01WN.

Family and domain databases

CDDicd07017. S14_ClpP_2. 1 hit.
HAMAPiMF_00444. ClpP. 1 hit.
InterProiView protein in InterPro
IPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR023562. ClpP/TepA.
IPR033135. ClpP_His_AS.
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiView protein in Pfam
PF00574. CLP_protease. 1 hit.
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiView protein in PROSITE
PS00382. CLP_PROTEASE_HIS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82CA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRPGAVVRR AGGYVTNLMP TAAGDPIGGG LGDQVYNRLL GERIIFLGQA
60 70 80 90 100
VDDDIANKIT AQLLLLASDP DKDIYLYINS PGGSITAGMA IYDTMQYIKN
110 120 130 140 150
DVVTIAMGMA ASMGQFLLSA GTPGKRFALP NAEILIHQPS AGLAGSASDI
160 170 180 190 200
KIHAERLLHT KKRMAELTAF HTGQTVEQVT RDSDRDRWFD PVEAKEYGLI
210
DDIMPTAAGM PGGGGTGAA
Length:219
Mass (Da):23,205
Last modified:June 1, 2003 - v1
Checksum:i0AA2BFF372889AE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC73159.1.

Genome annotation databases

EnsemblBacteriaiBAC73159; BAC73159; SAVERM_5447.
KEGGisma:SAV_5447.

Similar proteinsi

Entry informationi

Entry nameiCLPP3_STRAW
AccessioniPrimary (citable) accession number: Q82CA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: June 1, 2003
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families