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Q82C66

- SYL_STRAW

UniProt

Q82C66 - SYL_STRAW

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Protein
Leucine--tRNA ligase
Gene
leuS, SAV_5488
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei736 – 7361ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-5564-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SAV_5488
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 962962Leucine--tRNA ligaseUniRule annotation
PRO_0000152092Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_5488.

Structurei

3D structure databases

ProteinModelPortaliQ82C66.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi68 – 7912"HIGH" regionUniRule annotation
Add
BLAST
Motifi733 – 7375"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiLGMFPYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82C66-1 [UniParc]FASTAAdd to Basket

« Hide

MSETNPAAAS EVAAPHRYTA AVAAEIEARW QDFWDAEGTY EAPNPTGDLA    50
GGPALVAKPK KFVMDMFPYP SGAGLHVGHP LGYIATDVFA RFQRMTGHNV 100
LHTLGFDAFG LPAEQYAVQT GTHPRVSTEA NIENMKVQLR RLGLGHDKRR 150
SFATIDPDYY KWTQWIFLQI FNSWYDEEAN KARPIAELVA QFESGERAVP 200
RADGATRAWR ELTAAERADV LGEYRLAYAS EAPVNWSPGL GTVLANEEVT 250
ADGRSERGNF PVFKAKLRQW NMRITAYADR LLDDLDALDW PEAIKLQQRN 300
WIGRSEGARV DFPIDGEAVT VFTTRPDTLF GATYMVLAPE HPLVEKFTPA 350
AWPEGTHDVW TGGHATPAEA VAAYRAQAAS KSDVERQAEA KDKTGVFTGA 400
YATNPVSGEQ VPVFIADYVL MGYGTGAIMA VPAHDTRDFA FARAFELSMR 450
CVVEPSDDRG TDPSTWDDAF ASYDAKIVNS SSGEISLDGL GVVEAKARIT 500
EWLERKGLGE GTVNFRLRDW LFSRQRYWGE PFPIVYDEDG IAHALPESML 550
PLELPEVEDY SPRTFDPDDA NTSPETPLSR NEDWVNVTLD LGDGRGPQKY 600
RRETNTMPNW AGSCWYELRY LDPHNDQKLV DPAIEQYWMG PREGQPTGGV 650
DLYVGGAEHA VLHLLYARFW SKVLFDLGHI SSAEPFHKLF NQGMIQAYVY 700
RDSRGIAVPA AEVEERDGAY YYQGEKVSRL LGKMGKSLKN AVTPDEICAE 750
YGADTLRLYE MAMGPLDVSR PWDTRAVVGQ FRLLQRLWRN VVDEATGEVT 800
VVDAEPDEET LRALHKAIDG VRQDLEGMRF NTAIAKVTEL NNQLTKAGGP 850
VPRTVAESLV LLVAPLAPHI AEELWRKLGH NDSVVHQDFP VADPAYVVDE 900
AVTCVVQIKG KVKARLEVSP AISEEELEKV ALADEKVVAA LGGAGIRKVI 950
VRAPKLVNIV TA 962
Length:962
Mass (Da):106,570
Last modified:June 1, 2003 - v1
Checksum:i5EB57AE371334BF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000030 Genomic DNA. Translation: BAC73200.1.
RefSeqiNP_826665.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC73200; BAC73200; SAV_5488.
GeneIDi1211296.
KEGGisma:SAV_5488.
PATRICi23724970. VBIStrAve112782_5842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000030 Genomic DNA. Translation: BAC73200.1 .
RefSeqi NP_826665.1. NC_003155.4.

3D structure databases

ProteinModelPortali Q82C66.
ModBasei Search...

Protein-protein interaction databases

STRINGi 227882.SAV_5488.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC73200 ; BAC73200 ; SAV_5488 .
GeneIDi 1211296.
KEGGi sma:SAV_5488.
PATRICi 23724970. VBIStrAve112782_5842.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi LGMFPYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SAVE227882:GJU1-5564-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiSYL_STRAW
AccessioniPrimary (citable) accession number: Q82C66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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