ID   Q82BH8_STRAW            Unreviewed;       381 AA.
AC   Q82BH8;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 129.
DE   SubName: Full=Magnesium or manganese-dependent protein phosphatase {ECO:0000313|EMBL:BAC73439.1};
GN   Name=prpH {ECO:0000313|EMBL:BAC73439.1};
GN   ORFNames=SAVERM_5727 {ECO:0000313|EMBL:BAC73439.1};
OS   Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS   14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC73439.1, ECO:0000313|Proteomes:UP000000428};
RN   [1] {ECO:0000313|EMBL:BAC73439.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=11572948; DOI=10.1073/pnas.211433198;
RA   Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA   Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M.;
RT   "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT   deducing the ability of producing secondary metabolites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN   [2] {ECO:0000313|EMBL:BAC73439.1, ECO:0000313|Proteomes:UP000000428}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC   NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX   PubMed=12692562; DOI=10.1038/nbt820;
RA   Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA   Sakaki Y., Hattori M., Omura S.;
RT   "Complete genome sequence and comparative analysis of the industrial
RT   microorganism Streptomyces avermitilis.";
RL   Nat. Biotechnol. 21:526-531(2003).
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DR   EMBL; BA000030; BAC73439.1; -; Genomic_DNA.
DR   RefSeq; WP_010987129.1; NZ_JZJK01000057.1.
DR   AlphaFoldDB; Q82BH8; -.
DR   KEGG; sma:SAVERM_5727; -.
DR   eggNOG; COG0631; Bacteria.
DR   eggNOG; COG0789; Bacteria.
DR   HOGENOM; CLU_034545_3_2_11; -.
DR   OrthoDB; 9801841at2; -.
DR   Proteomes; UP000000428; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd01107; HTH_BmrR; 1.
DR   CDD; cd00143; PP2Cc; 1.
DR   Gene3D; 1.10.1660.10; -; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   InterPro; IPR047057; MerR_fam.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR30204:SF96; MERR FAMILY REGULATORY PROTEIN; 1.
DR   PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR   Pfam; PF13411; MerR_1; 1.
DR   Pfam; PF13672; PP2C_2; 1.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT   DOMAIN          1..71
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50937"
FT   DOMAIN          143..375
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51746"
FT   REGION          111..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   381 AA;  40191 MW;  601577DBF9992A21 CRC64;
     MLTIGAFAKA CRLSPKALRL YDELDLLRPA RVDPDTGYRY YAPEQLERAR LVAWLRRLGM
     PLARIRQVCA LDPGGAAREI RAYWARVEAE TTARRDLALF LVDHLTQSSQ APQASQSSAS
     SPSPQSSQSS PSSRKDTIML ELRYSALSDI GLVRDANQDT AYAGARVLAV ADGCGAGGAS
     ASTAAVEALK FLDEEPLPAG GVLNILEDAV QGAGRAVQDV AAAVGGSARD EIGTTLTAAV
     WTGSQLALVH IGDSRAYLLR DGELFLITHD HTVVQSLVDE GRLTPEEATV HPQRALLLKA
     LGGGPVPDPD LKLHDARPGD RYLLCSDGLS TVVPTEEIRR LLAAAPVPQA AARALVDAAN
     AAGGPDNVSC VVADVVEAGR Q
//