Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q82AK9

- COX1A_STRAW

UniProt

Q82AK9 - COX1A_STRAW

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable cytochrome c oxidase subunit 1-alpha

Gene

ctaD1

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper B ion per subunit.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901Iron (heme A axial ligand)By similarity
Metal bindingi268 – 2681Copper BBy similarity
Metal bindingi272 – 2721Copper BBy similarity
Metal bindingi317 – 3171Copper BBy similarity
Metal bindingi318 – 3181Copper BBy similarity
Metal bindingi401 – 4011Iron (heme A3 axial ligand)By similarity
Metal bindingi403 – 4031Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-6128-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaD1
Ordered Locus Names:SAV_6048
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421HelicalSequence AnalysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence AnalysisAdd
BLAST
Transmembranei125 – 14521HelicalSequence AnalysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence AnalysisAdd
BLAST
Transmembranei217 – 23721HelicalSequence AnalysisAdd
BLAST
Transmembranei262 – 28221HelicalSequence AnalysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence AnalysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence AnalysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence AnalysisAdd
BLAST
Transmembranei397 – 41721HelicalSequence AnalysisAdd
BLAST
Transmembranei437 – 45721HelicalSequence AnalysisAdd
BLAST
Transmembranei480 – 50021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Probable cytochrome c oxidase subunit 1-alphaPRO_0000183450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi227882.SAV_6048.

Structurei

3D structure databases

ProteinModelPortaliQ82AK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02274.
OMAiSAIVWVH.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82AK9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILNEPQGA AAAEDSYENE LPVRRKQPGN VVVKWLTTTD HKTIGTLYLV
60 70 80 90 100
TSFAFFCIGG VMALLMRAEL ARPGMQIMSS EQFNQAFTMH GTIMLLMFAT
110 120 130 140 150
PLFAGFANWI MPLQIGAPDV AFPRLNMFAY WLYLFGSLIA VGGFLTPQGA
160 170 180 190 200
ADFGWFAYSP LSDAVRSPGI GADMWIMGLA FSGFGTILGS VNFITTIICM
210 220 230 240 250
RAPGMTMFRM PIFVWNVLLT GVLVLLAFPV LAAALFALEA DRKFGAHVFD
260 270 280 290 300
AANGGALLWQ HLFWFFGHPE VYIIALPFFG IISEVIPVFS RKPMFGYMGL
310 320 330 340 350
IGATIAIAGL SVTVWAHHMY VTGGVLLPFF SFMTFLIAVP TGVKFFNWIG
360 370 380 390 400
TMWKGSLSFE TPMLWATGFL ITFTFGGLTG VILASPPMDF HVSDSYFVVA
410 420 430 440 450
HFHYVVFGTV VFAMFSGFHY WWPKFTGKML DERLGKITFW TLFVGFHGTF
460 470 480 490 500
LIQHWLGAEG MPRRYADYLA ADGFTALNTI STICSFLLGL SILPFLYNVW
510 520 530 540 550
KTAKYGKPVG VDDPWGYGRS LEWATSCPPP RHNFLTLPRI RSESPAFDLH
560 570
HPEIAALDQL ENAGHGEKAA VAGGKEAGK
Length:579
Mass (Da):63,950
Last modified:June 1, 2003 - v1
Checksum:i848C1E2D09B3589E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC73759.1.
RefSeqiNP_827224.1. NC_003155.4.
WP_010987449.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC73759; BAC73759; SAV_6048.
GeneIDi1211382.
KEGGisma:SAV_6048.
PATRICi23726122. VBIStrAve112782_6414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC73759.1 .
RefSeqi NP_827224.1. NC_003155.4.
WP_010987449.1. NC_003155.4.

3D structure databases

ProteinModelPortali Q82AK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227882.SAV_6048.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC73759 ; BAC73759 ; SAV_6048 .
GeneIDi 1211382.
KEGGi sma:SAV_6048.
PATRICi 23726122. VBIStrAve112782_6414.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02274.
OMAi SAIVWVH.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci SAVE227882:GJU1-6128-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiCOX1A_STRAW
AccessioniPrimary (citable) accession number: Q82AK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3