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Q82AK9

- COX1A_STRAW

UniProt

Q82AK9 - COX1A_STRAW

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Protein
Probable cytochrome c oxidase subunit 1-alpha
Gene
ctaD1, SAV_6048
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit By similarity.
Binds 2 heme groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901Iron (heme A axial ligand) By similarity
Metal bindingi268 – 2681Copper B By similarity
Metal bindingi272 – 2721Copper B By similarity
Metal bindingi317 – 3171Copper B By similarity
Metal bindingi318 – 3181Copper B By similarity
Metal bindingi401 – 4011Iron (heme A3 axial ligand) By similarity
Metal bindingi403 – 4031Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-6128-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaD1
Ordered Locus Names:SAV_6048
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei44 – 6421Helical; Reviewed prediction
Add
BLAST
Transmembranei93 – 11321Helical; Reviewed prediction
Add
BLAST
Transmembranei125 – 14521Helical; Reviewed prediction
Add
BLAST
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Reviewed prediction
Add
BLAST
Transmembranei262 – 28221Helical; Reviewed prediction
Add
BLAST
Transmembranei295 – 31521Helical; Reviewed prediction
Add
BLAST
Transmembranei319 – 33921Helical; Reviewed prediction
Add
BLAST
Transmembranei363 – 38321Helical; Reviewed prediction
Add
BLAST
Transmembranei397 – 41721Helical; Reviewed prediction
Add
BLAST
Transmembranei437 – 45721Helical; Reviewed prediction
Add
BLAST
Transmembranei480 – 50021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Probable cytochrome c oxidase subunit 1-alpha
PRO_0000183450Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi227882.SAV_6048.

Structurei

3D structure databases

ProteinModelPortaliQ82AK9.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
KOiK02274.
OMAiSAIVWVH.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82AK9-1 [UniParc]FASTAAdd to Basket

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MSILNEPQGA AAAEDSYENE LPVRRKQPGN VVVKWLTTTD HKTIGTLYLV    50
TSFAFFCIGG VMALLMRAEL ARPGMQIMSS EQFNQAFTMH GTIMLLMFAT 100
PLFAGFANWI MPLQIGAPDV AFPRLNMFAY WLYLFGSLIA VGGFLTPQGA 150
ADFGWFAYSP LSDAVRSPGI GADMWIMGLA FSGFGTILGS VNFITTIICM 200
RAPGMTMFRM PIFVWNVLLT GVLVLLAFPV LAAALFALEA DRKFGAHVFD 250
AANGGALLWQ HLFWFFGHPE VYIIALPFFG IISEVIPVFS RKPMFGYMGL 300
IGATIAIAGL SVTVWAHHMY VTGGVLLPFF SFMTFLIAVP TGVKFFNWIG 350
TMWKGSLSFE TPMLWATGFL ITFTFGGLTG VILASPPMDF HVSDSYFVVA 400
HFHYVVFGTV VFAMFSGFHY WWPKFTGKML DERLGKITFW TLFVGFHGTF 450
LIQHWLGAEG MPRRYADYLA ADGFTALNTI STICSFLLGL SILPFLYNVW 500
KTAKYGKPVG VDDPWGYGRS LEWATSCPPP RHNFLTLPRI RSESPAFDLH 550
HPEIAALDQL ENAGHGEKAA VAGGKEAGK 579
Length:579
Mass (Da):63,950
Last modified:June 1, 2003 - v1
Checksum:i848C1E2D09B3589E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000030 Genomic DNA. Translation: BAC73759.1.
RefSeqiNP_827224.1. NC_003155.4.
WP_010987449.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC73759; BAC73759; SAV_6048.
GeneIDi1211382.
KEGGisma:SAV_6048.
PATRICi23726122. VBIStrAve112782_6414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000030 Genomic DNA. Translation: BAC73759.1 .
RefSeqi NP_827224.1. NC_003155.4.
WP_010987449.1. NC_003155.4.

3D structure databases

ProteinModelPortali Q82AK9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227882.SAV_6048.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC73759 ; BAC73759 ; SAV_6048 .
GeneIDi 1211382.
KEGGi sma:SAV_6048.
PATRICi 23726122. VBIStrAve112782_6414.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
KOi K02274.
OMAi SAIVWVH.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci SAVE227882:GJU1-6128-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiCOX1A_STRAW
AccessioniPrimary (citable) accession number: Q82AK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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