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Q82AK9

- COX1A_STRAW

UniProt

Q82AK9 - COX1A_STRAW

Protein

Probable cytochrome c oxidase subunit 1-alpha

Gene

ctaD1

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B per subunit.By similarity
    Binds 2 heme groups per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi90 – 901Iron (heme A axial ligand)By similarity
    Metal bindingi268 – 2681Copper BBy similarity
    Metal bindingi272 – 2721Copper BBy similarity
    Metal bindingi317 – 3171Copper BBy similarity
    Metal bindingi318 – 3181Copper BBy similarity
    Metal bindingi401 – 4011Iron (heme A3 axial ligand)By similarity
    Metal bindingi403 – 4031Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciSAVE227882:GJU1-6128-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1-alpha
    Cytochrome c oxidase polypeptide I-alpha
    Gene namesi
    Name:ctaD1
    Ordered Locus Names:SAV_6048
    OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
    Taxonomic identifieri227882 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000000428: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579Probable cytochrome c oxidase subunit 1-alphaPRO_0000183450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Subunit structurei

    Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

    Protein-protein interaction databases

    STRINGi227882.SAV_6048.

    Structurei

    3D structure databases

    ProteinModelPortaliQ82AK9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei174 – 19421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei397 – 41721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei480 – 50021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    HOGENOMiHOG000085274.
    KOiK02274.
    OMAiSAIVWVH.
    OrthoDBiEOG6B35XR.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q82AK9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILNEPQGA AAAEDSYENE LPVRRKQPGN VVVKWLTTTD HKTIGTLYLV    50
    TSFAFFCIGG VMALLMRAEL ARPGMQIMSS EQFNQAFTMH GTIMLLMFAT 100
    PLFAGFANWI MPLQIGAPDV AFPRLNMFAY WLYLFGSLIA VGGFLTPQGA 150
    ADFGWFAYSP LSDAVRSPGI GADMWIMGLA FSGFGTILGS VNFITTIICM 200
    RAPGMTMFRM PIFVWNVLLT GVLVLLAFPV LAAALFALEA DRKFGAHVFD 250
    AANGGALLWQ HLFWFFGHPE VYIIALPFFG IISEVIPVFS RKPMFGYMGL 300
    IGATIAIAGL SVTVWAHHMY VTGGVLLPFF SFMTFLIAVP TGVKFFNWIG 350
    TMWKGSLSFE TPMLWATGFL ITFTFGGLTG VILASPPMDF HVSDSYFVVA 400
    HFHYVVFGTV VFAMFSGFHY WWPKFTGKML DERLGKITFW TLFVGFHGTF 450
    LIQHWLGAEG MPRRYADYLA ADGFTALNTI STICSFLLGL SILPFLYNVW 500
    KTAKYGKPVG VDDPWGYGRS LEWATSCPPP RHNFLTLPRI RSESPAFDLH 550
    HPEIAALDQL ENAGHGEKAA VAGGKEAGK 579
    Length:579
    Mass (Da):63,950
    Last modified:June 1, 2003 - v1
    Checksum:i848C1E2D09B3589E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000030 Genomic DNA. Translation: BAC73759.1.
    RefSeqiNP_827224.1. NC_003155.4.
    WP_010987449.1. NC_003155.4.

    Genome annotation databases

    EnsemblBacteriaiBAC73759; BAC73759; SAV_6048.
    GeneIDi1211382.
    KEGGisma:SAV_6048.
    PATRICi23726122. VBIStrAve112782_6414.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000030 Genomic DNA. Translation: BAC73759.1 .
    RefSeqi NP_827224.1. NC_003155.4.
    WP_010987449.1. NC_003155.4.

    3D structure databases

    ProteinModelPortali Q82AK9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227882.SAV_6048.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC73759 ; BAC73759 ; SAV_6048 .
    GeneIDi 1211382.
    KEGGi sma:SAV_6048.
    PATRICi 23726122. VBIStrAve112782_6414.

    Phylogenomic databases

    eggNOGi COG0843.
    HOGENOMi HOG000085274.
    KOi K02274.
    OMAi SAIVWVH.
    OrthoDBi EOG6B35XR.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci SAVE227882:GJU1-6128-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
      Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
      Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
    2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
      Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
      Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

    Entry informationi

    Entry nameiCOX1A_STRAW
    AccessioniPrimary (citable) accession number: Q82AK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3