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Protein

Probable cytochrome c oxidase subunit 1-alpha

Gene

ctaD1

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper B ion per subunit.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi90Iron (heme A axial ligand)By similarity1
Metal bindingi268Copper BBy similarity1
Metal bindingi272Copper BBy similarity1
Metal bindingi317Copper BBy similarity1
Metal bindingi318Copper BBy similarity1
Metal bindingi401Iron (heme A3 axial ligand)By similarity1
Metal bindingi403Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaD1
Ordered Locus Names:SAV_6048
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Transmembranei397 – 417HelicalSequence analysisAdd BLAST21
Transmembranei437 – 457HelicalSequence analysisAdd BLAST21
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834501 – 579Probable cytochrome c oxidase subunit 1-alphaAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki268 ↔ 2721'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi227882.SAV_6048.

Structurei

3D structure databases

ProteinModelPortaliQ82AK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiPOG091H042R.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82AK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILNEPQGA AAAEDSYENE LPVRRKQPGN VVVKWLTTTD HKTIGTLYLV
60 70 80 90 100
TSFAFFCIGG VMALLMRAEL ARPGMQIMSS EQFNQAFTMH GTIMLLMFAT
110 120 130 140 150
PLFAGFANWI MPLQIGAPDV AFPRLNMFAY WLYLFGSLIA VGGFLTPQGA
160 170 180 190 200
ADFGWFAYSP LSDAVRSPGI GADMWIMGLA FSGFGTILGS VNFITTIICM
210 220 230 240 250
RAPGMTMFRM PIFVWNVLLT GVLVLLAFPV LAAALFALEA DRKFGAHVFD
260 270 280 290 300
AANGGALLWQ HLFWFFGHPE VYIIALPFFG IISEVIPVFS RKPMFGYMGL
310 320 330 340 350
IGATIAIAGL SVTVWAHHMY VTGGVLLPFF SFMTFLIAVP TGVKFFNWIG
360 370 380 390 400
TMWKGSLSFE TPMLWATGFL ITFTFGGLTG VILASPPMDF HVSDSYFVVA
410 420 430 440 450
HFHYVVFGTV VFAMFSGFHY WWPKFTGKML DERLGKITFW TLFVGFHGTF
460 470 480 490 500
LIQHWLGAEG MPRRYADYLA ADGFTALNTI STICSFLLGL SILPFLYNVW
510 520 530 540 550
KTAKYGKPVG VDDPWGYGRS LEWATSCPPP RHNFLTLPRI RSESPAFDLH
560 570
HPEIAALDQL ENAGHGEKAA VAGGKEAGK
Length:579
Mass (Da):63,950
Last modified:June 1, 2003 - v1
Checksum:i848C1E2D09B3589E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC73759.1.
RefSeqiWP_010987449.1. NZ_JZJK01000089.1.

Genome annotation databases

EnsemblBacteriaiBAC73759; BAC73759; SAVERM_6048.
KEGGisma:SAV_6048.
PATRICi23726122. VBIStrAve112782_6414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC73759.1.
RefSeqiWP_010987449.1. NZ_JZJK01000089.1.

3D structure databases

ProteinModelPortaliQ82AK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_6048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC73759; BAC73759; SAVERM_6048.
KEGGisma:SAV_6048.
PATRICi23726122. VBIStrAve112782_6414.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiPOG091H042R.

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX1A_STRAW
AccessioniPrimary (citable) accession number: Q82AK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.