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Protein

Probable cytochrome c oxidase polypeptide 4

Gene

ctaF

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of cytochrome c oxidase, its function is unknown.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-6129-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase polypeptide 4 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV
Gene namesi
Name:ctaF
Ordered Locus Names:SAV_6049
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Probable cytochrome c oxidase polypeptide 4PRO_0000220021Add
BLAST

Interactioni

Subunit structurei

Associates with subunits I, II and III to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi227882.SAV_6049.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG07397.
HOGENOMiHOG000237887.
OMAiGTYFRFV.
OrthoDBiEOG63FW2X.

Family and domain databases

InterProiIPR021050. Cyt_c_oxidase_su4_actinobac.
[Graphical view]
PfamiPF12270. Cyt_c_ox_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF017385. CtaF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82AK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIQGKMFIW LAVFILAMAI IYGVWSKEPA GTTALFLAFG LSIMIGYYLA
60 70 80 90 100
FTARRVDAGA QDNKEADVAD DAGEVGFFSP HSWQPLALGI GGALAFMGVV
110 120 130
FGWWLLYFSA PIILIGLWGW VFEYYRGESR TQ
Length:132
Mass (Da):14,643
Last modified:June 1, 2003 - v1
Checksum:i23758A003AEA6E29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC73760.1.
RefSeqiNP_827225.1. NC_003155.4.

Genome annotation databases

EnsemblBacteriaiBAC73760; BAC73760; SAV_6049.
GeneIDi1216508.
KEGGisma:SAV_6049.
PATRICi23726124. VBIStrAve112782_6415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC73760.1.
RefSeqiNP_827225.1. NC_003155.4.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_6049.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC73760; BAC73760; SAV_6049.
GeneIDi1216508.
KEGGisma:SAV_6049.
PATRICi23726124. VBIStrAve112782_6415.

Phylogenomic databases

eggNOGiNOG07397.
HOGENOMiHOG000237887.
OMAiGTYFRFV.
OrthoDBiEOG63FW2X.

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-6129-MONOMER.

Family and domain databases

InterProiIPR021050. Cyt_c_oxidase_su4_actinobac.
[Graphical view]
PfamiPF12270. Cyt_c_ox_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF017385. CtaF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiCOX4_STRAW
AccessioniPrimary (citable) accession number: Q82AK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2003
Last modified: March 4, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.