Q82AK8 (COX4_STRAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c oxidase polypeptide 4
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV

Gene names

Name:	ctaF
Ordered Locus Names:	SAV_6049

Organism

Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) [Complete proteome] [HAMAP]

Taxonomic identifier

227882 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces avermitilis

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of cytochrome c oxidase, its function is unknown By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subunit structure	Associates with subunits I, II and III to form cytochrome c oxidase By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase bacterial subunit CtaF family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	Probable cytochrome c oxidase polypeptide 4		PRO_0000220021
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	107 – 127	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q82AK8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 23758A003AEA6E29	FASTA	132	14,643
	10 20 30 40 50 60 MKIQGKMFIW LAVFILAMAI IYGVWSKEPA GTTALFLAFG LSIMIGYYLA FTARRVDAGA 70 80 90 100 110 120 QDNKEADVAD DAGEVGFFSP HSWQPLALGI GGALAFMGVV FGWWLLYFSA PIILIGLWGW 130 VFEYYRGESR TQ

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000030 Genomic DNA. Translation: BAC73760.1.
RefSeq	NP_827225.1. NC_003155.4.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	227882.SAV_6049.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAC73760; BAC73760; SAV_6049.
GeneID	1216508.
KEGG	sma:SAV_6049.
PATRIC	23726124. VBIStrAve112782_6415.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG07397.
HOGENOM	HOG000237887.
OMA	YFRFVAR.
ProtClustDB	CLSK2519269.
Enzyme and pathway databases
BioCyc	SAVE227882:GJU1-6129-MONOMER.
Family and domain databases
InterPro	IPR021050. Cyt_c_oxidase_su4_actinobac. [Graphical view]
Pfam	PF12270. Cyt_c_ox_IV. 1 hit. [Graphical view]
PIRSF	PIRSF017385. CtaF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COX4_STRAW

Accession

Primary (citable) accession number: Q82AK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program