Q82AF8 (Q82AF8_STRAW) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Name:	metF EMBL BAC73811.1
Ordered Locus Names:	SAV_6100 EMBL BAC73811.1

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q82AF8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7712D955466AC2DF	FASTA	307	33,430
	10 20 30 40 50 60 MALGTASTRT DRARTVRDML ASGKTTYSFE FSAPKTPKGE RNLWSALRRV EAVAPDFVSV 70 80 90 100 110 120 TYGAGGSTRA GTVKETEQIV ADTTLTPVAH LTAVNHSIAE LRNIIGQYAD AGIRNMLAVR 130 140 150 160 170 180 GDPPGDPMGE WVPHPRGLTY AAELVRLIKE SGDFCVGVAA FPEMHPRSAD WEADVERFVD 190 200 210 220 230 240 KCRAGADYAI TQMFFHPESY LRLRDRVAAA GCETPVIPEI MPVTSVKMLE RLPQLSNAAI 250 260 270 280 290 300 PSVLQERILT AKDDPAAVRS IGIEFATEFC ARLLAEGVPG LHFITLNNST ATLEIYENLG LHHPQQA

References

[1]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000030 Genomic DNA. Translation: BAC73811.1.
RefSeq	NP_827276.1. NC_003155.4.
3D structure databases
HSSP	HSSP built from PDB template 1B5T based on UniProtKB P00394.
ProteinModelPortal	Q82AF8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1211402.
GenomeReviews	Gene locus SAV6100 in contig BA000030_GR.
KEGG	sma:SAV_6100.
NMPDR	fig|227882.1.peg.6102.
PATRIC	23726232. VBIStrAve112782_6469.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK902283.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV6100-MONOMER.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. IPR004620. MTHF_reductase_bac. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00676. Fadh2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q82AF8_STRAW

Accession

Primary (citable) accession number: Q82AF8

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)