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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:SAV_6119
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000000428 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei153 – 173HelicalUniRule annotationAdd BLAST21
Transmembranei186 – 206HelicalUniRule annotationAdd BLAST21
Transmembranei228 – 248HelicalUniRule annotationAdd BLAST21
Transmembranei255 – 275HelicalUniRule annotationAdd BLAST21
Transmembranei280 – 300HelicalUniRule annotationAdd BLAST21
Transmembranei334 – 354HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001089011 – 357Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST357

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_6119.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82AD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKQILFSGV IGLFLTLVGT PLLIKLLARK GYGQYIRDDG PREHHSKRGT
60 70 80 90 100
PTMGGIAFIL ATIIAYFMSK VITGYTPTFS GLLVLGLMAG MGLVGFLDDY
110 120 130 140 150
IKIVKRRSLG LRAKAKMAGQ LIVGIAFAVL ALQFADNHGN TPASTRLSFV
160 170 180 190 200
EDFGWTIGPV LFVIWALFMI LAMSNGVNLT DGLDGLATGA ATMVFGAYTF
210 220 230 240 250
IGVWQFQESC ANAQTLTNPA ACYEVRDPLD LAVVASALMG ACFGFLWWNT
260 270 280 290 300
SPAKIFMGDT GSLALGGALA GLAICSRTEL LVALLGGLFV LITMSVVIQV
310 320 330 340 350
GSFRLTGKRV FRMAPLQHHF ELKGWSEVLV VVRFWIIQGM CVIVGLGLFY

AGWAAKK
Length:357
Mass (Da):38,440
Last modified:June 1, 2003 - v1
Checksum:i5BFDDF616C452B5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC73830.1.
RefSeqiWP_010987520.1. NZ_JZJK01000089.1.

Genome annotation databases

EnsemblBacteriaiBAC73830; BAC73830; SAVERM_6119.
KEGGisma:SAV_6119.

Similar proteinsi

Entry informationi

Entry nameiMRAY_STRAW
AccessioniPrimary (citable) accession number: Q82AD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: June 7, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families