Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate isomerase 2

Gene

pgi2

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei359 – 3591Proton donorUniRule annotation
Active sitei390 – 3901UniRule annotation
Active sitei514 – 5141UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSAVE227882:GJU1-6383-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase 2UniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPI 2UniRule annotation
Alternative name(s):
Phosphoglucose isomerase 2UniRule annotation
Short name:
PGI 2UniRule annotation
Phosphohexose isomerase 2UniRule annotation
Short name:
PHI 2UniRule annotation
Gene namesi
Name:pgi2UniRule annotation
Ordered Locus Names:SAV_6302
OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Taxonomic identifieri227882 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000000428 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 550550Glucose-6-phosphate isomerase 2PRO_0000180748Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227882.SAV_6302.

Structurei

3D structure databases

ProteinModelPortaliQ829V7.
SMRiQ829V7. Positions 2-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OMAiKSHNPIH.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q829V7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNADSRTRLN QRPEWTALAK HREELAGTHL RDLFAADPGR GAGYTLEVGD
60 70 80 90 100
LHVDYSKHLV TDETLRLLRE LAAATDVFGL RDAMFRGEKI NVTEDRAVLH
110 120 130 140 150
TALRAPRDAV VEVDGENVVP AVHAVLDKMS TFAERVRTGE WTGHTGKPIK
160 170 180 190 200
NIVNVGIGGS DLGPAMAYEV LRSFTDRSLT VRFVSNVDGA DLHEAVRDLD
210 220 230 240 250
PAETLFVIAS KTFTTIETIT NATSARDWLL TELKAGQEAV AKHFVALSTN
260 270 280 290 300
AEKVSEFGID TANMFEFWDW VGGRYSFDSA IGLSLMIAIG PERFREMLDG
310 320 330 340 350
FRIVDEHFES APAEDNVPLL LGLLGIWYGN FHDAQSHAVL PYSHYLSKFT
360 370 380 390 400
AYLQQLDMES NGKSVQRDGN PVEWETGPVV WGTPGTNGQH AYYQLIHQGT
410 420 430 440 450
KLIPADFIGF AEPVADLLPG LVAQHDLLMA NFFAQTQALA FGKTPDEVRA
460 470 480 490 500
EGVPEQLVPH KTFKGNHPTT TILAKELTPS VLGQLIALYE HKVFVQGAVW
510 520 530 540 550
NIDSFDQWGV ELGKVLAKRV EPALTEGADV PGLDESTKAL VAKYRQLRGR
Length:550
Mass (Da):60,636
Last modified:June 1, 2003 - v1
Checksum:i3AFA3A5540572DAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC74013.1.
RefSeqiNP_827478.1. NC_003155.4.
WP_010987702.1. NZ_BAVY01000017.1.

Genome annotation databases

EnsemblBacteriaiBAC74013; BAC74013; SAV_6302.
KEGGisma:SAV_6302.
PATRICi23726660. VBIStrAve112782_6682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000030 Genomic DNA. Translation: BAC74013.1.
RefSeqiNP_827478.1. NC_003155.4.
WP_010987702.1. NZ_BAVY01000017.1.

3D structure databases

ProteinModelPortaliQ829V7.
SMRiQ829V7. Positions 2-548.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi227882.SAV_6302.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC74013; BAC74013; SAV_6302.
KEGGisma:SAV_6302.
PATRICi23726660. VBIStrAve112782_6682.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OMAiKSHNPIH.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciSAVE227882:GJU1-6383-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
    Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
    Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
  2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
    Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
    Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Entry informationi

Entry nameiG6PI2_STRAW
AccessioniPrimary (citable) accession number: Q829V7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: April 29, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.