Q829B4 (PPNK2_STRAW) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase 2
Short name=Poly(P)/ATP NAD kinase 2
EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	SAV_6497

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP MF_00361		PRO_0000120668

Sequences

	Sequence		Length	Mass (Da)
	Q829B4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 143DB3E6D5646E7A	FASTA	301	32,140
	10 20 30 40 50 60 MTQTRARTVF LLAHTGRPAA IRSAELVVQG LLRSGLGVRV LEAEAADLPL PDEVELVKEA 70 80 90 100 110 120 TPQCLDGCEL LIVLGGDGTL LRGAEFARAS GVPMLGVNLG RVGFLAEAER DDLDKVVDRV 130 140 150 160 170 180 VTKAYEVEER MTVDVVVHKN GDIVHTDWAL NEAAVQKVSA ERLLEVVLEI DGRPVTGFGC 190 200 210 220 230 240 DGIVCATPTG STAYAFSAGG PVVWPEVEAL LMVPISAHAL FAKPLVTSPN SVLAVEVQPD 250 260 270 280 290 300 TPHGVLWCDG RRTVELPQGA RVEVRRGAVP VRLARLHHAS FTDRLVAKFA LPVAGWRGAP H

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000030 Genomic DNA. Translation: BAC74208.1.
RefSeq	NP_827673.1. NC_003155.4.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1216845.
GenomeReviews	Gene locus SAV_6497 in contig BA000030_GR.
KEGG	sma:SAV_6497.
NMPDR	fig|227882.1.peg.6499.
PATRIC	23727082. VBIStrAve112782_6890.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG713904.
OMA	GPVVWPE.
ProtClustDB	PRK03372.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV6497-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK2_STRAW

Accession

Primary (citable) accession number: Q829B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program