Reviewed, UniProtKB/Swiss-Prot Q828S5 (HGD_STRAW)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	SAV_6587

Organism

Streptomyces avermitilis [Complete proteome] [HAMAP]

Taxonomic identifier

33903 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_0000220255
Sites
	Metal binding	337	1	Iron By similarity
	Metal binding	343	1	Iron By similarity
	Metal binding	373	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q828S5-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 8E751EBA9B6F53BC	FASTA	438	47,823
	10 20 30 40 50 60 MSGDARKTAE GLAHLTGFGN EHASEAVPGA LPEGRNSPQR APLGLYAEQL SGSAFTEPRA 70 80 90 100 110 120 HNRRSWLYRI RPSAAHPPFT RADNGAIRTA PFTETAPDPN RLRWNPLPEP PAGTDFVGGL 130 140 150 160 170 180 WTLGGNGDAT QRTGMAVHLY HANSSMDRVF SDADGELLIV PERGGLLLRT EFGLLHAEPG 190 200 210 220 230 240 QVALVPRGVR FRVDLLDESA RGYVCENYGA PFQLPDLGPI GANGLAAARD FKAPVAAYED 250 260 270 280 290 300 VEGPVEVVNK FCGNLWTATY DHSPLDVVAW HGNHVPYTYD LRRFNVLGTI SYDHPDPSIF 310 320 330 340 350 360 TVLTSPSDTP GLAGVDFVVF APRWLVGEDT FRPPYFHRNV MSEYMGLIEG AYDAKAAGFV 370 380 390 400 410 420 PGGGSLHNMM SAHGPDRETF DRASAAELRP QKIDDGLAFM FETRWPVTAT AQAARAEHLQ 430 PAYDDVWQGL QRHFRPSD

References

[1]

"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites." Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

[2]

"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis." Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S. Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000030 Genomic DNA. Translation: BAC74298.1.
RefSeq	NP_827763.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1211514.
GenomeReviews	Gene locus SAV_6587 in contig BA000030_GR.
KEGG	sma:SAV_6587.
NMPDR	fig|227882.1.peg.6589.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q828S5.
OMA	HRNCMSE.
Enzyme and pathway databases
BioCyc	SAVE227882:SAV6587-MON.
BRENDA	1.13.11.5. 140873.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_STRAW

Accession

Primary (citable) accession number: Q828S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 4, 2003
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)