Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q827D7 (GCSP_STRAW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Synonyms:gcvB
Ordered Locus Names:SAV_6987
OrganismStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) [Complete proteome] [HAMAP]
Taxonomic identifier227882 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length961 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence caution

The sequence BAC74698.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 961961Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166938

Amino acid modifications

Modified residue7091N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q827D7 [UniParc].

Last modified September 19, 2003. Version 2.
Checksum: FC4CB0D2E06C32DD

FASTA961102,650
        10         20         30         40         50         60 
MTAHRIPLSD LEQGIPFEQR HIGPDSEARA KMLAQVGYGS LDELTATAVP DVIKNAEALE 

        70         80         90        100        110        120 
LPGARTEAEV LAELRSLADR NQVLGSMIGL GYYGTFTPPV ILRNVMENPA WYTAYTPYQP 

       130        140        150        160        170        180 
EISQGRLEAL LNFQTVVAEL TGLPTSGASL LDEGTAAAEA MALSRRMGKN KKGLFLVDAD 

       190        200        210        220        230        240 
ALPQTIAVIE TRAEPTGVEV VVADLSEGIP AGIAEREING VLIQYPGASG AVRDIKPLVE 

       250        260        270        280        290        300 
QAHELGAVVT VAADLLALTL LTSPGELGAD IAVGTTQRFG VPMGFGGPHA GYMAVREKFA 

       310        320        330        340        350        360 
RSLPGRLVGV SVDADGHKAY RLALQTREQH IRREKATSNI CTAQVLLAVM AGMYAVYHGP 

       370        380        390        400        410        420 
DGLRTIARRT HRYATILAEG LKAGGVEVVH GAYFDTLTAR VPGRAAEIVA AAREGGVNLH 

       430        440        450        460        470        480 
LVDADLVSIS CDETTTRAQL GAVWTAFGVE GDIEALDAAA EDTLPAALLR TDDYLTHPVF 

       490        500        510        520        530        540 
HQYRSETAML RYLRRLSDRD YALDRGMIPL GSCTMKLNAT TEMEPVTWPE FGQLHPFAPA 

       550        560        570        580        590        600 
EQAQGYLTLI RELEERLAEV TGYDKVSLQP NAGSQGELAG LLAVRGYHRA NGDEQRTVCL 

       610        620        630        640        650        660 
IPSSAHGTNA ASAVMAGMKV VVVKTADDGE IDVEDLRAKI EQYRDELSVL MITYPSTHGV 

       670        680        690        700        710        720 
FEEHVADICA QVHEAGGQVY VDGANLNALV GLAKPGHFGG DVSHLNLHKT FCIPHGGGGP 

       730        740        750        760        770        780 
GVGPVGVRAH LAPYLPNHPL QPEAGPATGV GPISAAPWGS AGILPISWSY VRLMGGEGLK 

       790        800        810        820        830        840 
RATQVAVLSA NYIAKRLEPH YPVLYTGPGG LVAHECIIDL RPLTKATGVS VDDIAKRLID 

       850        860        870        880        890        900 
YGFHAPTMSF PVAGTLMIEP TESEDLGELD RFCEAMIAIR AEVEKVGSGE WPAEDNPLRN 

       910        920        930        940        950        960 
APHTAAALGG EWEHAYSREE AVFPAGVSAA DKYWPPVRRI DQAFGDRNLV CSCPPLDAYD 


D 

« Hide

References

[1]"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
[2]"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000030 Genomic DNA. Translation: BAC74698.1. Different initiation.
RefSeqNP_828163.1. NC_003155.4.

3D structure databases

ProteinModelPortalQ827D7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227882.SAV_6987.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC74698; BAC74698; SAV_6987.
GeneID1211643.
KEGGsma:SAV_6987.
PATRIC23728124. VBIStrAve112782_7401.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycSAVE227882:GJU1-7083-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_STRAW
AccessionPrimary (citable) accession number: Q827D7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: September 19, 2003
Last modified: February 19, 2014
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families