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Q827D7

- GCSP_STRAW

UniProt

Q827D7 - GCSP_STRAW

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (19 Sep 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSAVE227882:GJU1-7083-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Synonyms:gcvB
    Ordered Locus Names:SAV_6987
    OrganismiStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680)
    Taxonomic identifieri227882 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000000428: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 961961Glycine dehydrogenase (decarboxylating)PRO_0000166938Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei709 – 7091N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi227882.SAV_6987.

    Structurei

    3D structure databases

    ProteinModelPortaliQ827D7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFHQYRSE.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q827D7-1 [UniParc]FASTAAdd to Basket

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    MTAHRIPLSD LEQGIPFEQR HIGPDSEARA KMLAQVGYGS LDELTATAVP    50
    DVIKNAEALE LPGARTEAEV LAELRSLADR NQVLGSMIGL GYYGTFTPPV 100
    ILRNVMENPA WYTAYTPYQP EISQGRLEAL LNFQTVVAEL TGLPTSGASL 150
    LDEGTAAAEA MALSRRMGKN KKGLFLVDAD ALPQTIAVIE TRAEPTGVEV 200
    VVADLSEGIP AGIAEREING VLIQYPGASG AVRDIKPLVE QAHELGAVVT 250
    VAADLLALTL LTSPGELGAD IAVGTTQRFG VPMGFGGPHA GYMAVREKFA 300
    RSLPGRLVGV SVDADGHKAY RLALQTREQH IRREKATSNI CTAQVLLAVM 350
    AGMYAVYHGP DGLRTIARRT HRYATILAEG LKAGGVEVVH GAYFDTLTAR 400
    VPGRAAEIVA AAREGGVNLH LVDADLVSIS CDETTTRAQL GAVWTAFGVE 450
    GDIEALDAAA EDTLPAALLR TDDYLTHPVF HQYRSETAML RYLRRLSDRD 500
    YALDRGMIPL GSCTMKLNAT TEMEPVTWPE FGQLHPFAPA EQAQGYLTLI 550
    RELEERLAEV TGYDKVSLQP NAGSQGELAG LLAVRGYHRA NGDEQRTVCL 600
    IPSSAHGTNA ASAVMAGMKV VVVKTADDGE IDVEDLRAKI EQYRDELSVL 650
    MITYPSTHGV FEEHVADICA QVHEAGGQVY VDGANLNALV GLAKPGHFGG 700
    DVSHLNLHKT FCIPHGGGGP GVGPVGVRAH LAPYLPNHPL QPEAGPATGV 750
    GPISAAPWGS AGILPISWSY VRLMGGEGLK RATQVAVLSA NYIAKRLEPH 800
    YPVLYTGPGG LVAHECIIDL RPLTKATGVS VDDIAKRLID YGFHAPTMSF 850
    PVAGTLMIEP TESEDLGELD RFCEAMIAIR AEVEKVGSGE WPAEDNPLRN 900
    APHTAAALGG EWEHAYSREE AVFPAGVSAA DKYWPPVRRI DQAFGDRNLV 950
    CSCPPLDAYD D 961
    Length:961
    Mass (Da):102,650
    Last modified:September 19, 2003 - v2
    Checksum:iFC4CB0D2E06C32DD
    GO

    Sequence cautioni

    The sequence BAC74698.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000030 Genomic DNA. Translation: BAC74698.1. Different initiation.
    RefSeqiNP_828163.1. NC_003155.4.

    Genome annotation databases

    EnsemblBacteriaiBAC74698; BAC74698; SAV_6987.
    GeneIDi1211643.
    KEGGisma:SAV_6987.
    PATRICi23728124. VBIStrAve112782_7401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000030 Genomic DNA. Translation: BAC74698.1 . Different initiation.
    RefSeqi NP_828163.1. NC_003155.4.

    3D structure databases

    ProteinModelPortali Q827D7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227882.SAV_6987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC74698 ; BAC74698 ; SAV_6987 .
    GeneIDi 1211643.
    KEGGi sma:SAV_6987.
    PATRICi 23728124. VBIStrAve112782_7401.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FHQYRSE.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SAVE227882:GJU1-7083-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
      Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
      Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
    2. "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
      Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
      Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

    Entry informationi

    Entry nameiGCSP_STRAW
    AccessioniPrimary (citable) accession number: Q827D7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: September 19, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3