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Reviewed, UniProtKB/Swiss-Prot Q827A4 (UPPP2_STRAW)

Last modified February 9, 2010. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Undecaprenyl-diphosphatase 2
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 2
    Bacitracin resistance protein 2
Gene names
Name: uppP2
Synonyms: bacA2, upk2
Ordered Locus Names: SAV_7021
OrganismStreptomyces avermitilis [Complete proteome] [HAMAP]
Taxonomic identifier33903 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

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Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006

Catalytic activity

Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006

Sequence similarities

Belongs to the uppP family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 291291Undecaprenyl-diphosphatase 2 HAMAP MF_01006
PRO_0000151210

Regions

Transmembrane39 – 5921 Potential
Transmembrane85 – 10521 Potential
Transmembrane118 – 13821 Potential
Transmembrane203 – 22321 Potential
Transmembrane231 – 25121 Potential
Transmembrane262 – 28221 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q827A4-1 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 568C2DB6AD5D6196

FASTA29131,149
        10         20         30         40         50         60 
MSWFESLILG LVQGLTEFLP VSSSAHLRLT AAFAGWEDPG AAFTAITQIG TEAAVLIYFR 

        70         80         90        100        110        120 
KDIARIISAW FRSLVNKEMR HDHDAQMGWL VIVGSIPIGV LGVTLKDQIE GPFRDLRITA 

       130        140        150        160        170        180 
TMLIVMGVIL GIADRLAARD ETGGKHRAAK ERKKLQDLNI RDGLVFGACQ AMALIPGVSR 

       190        200        210        220        230        240 
SGATISGGLL IGYTRESAAR YSFLLAIPAV LASGVFELKD AAASGHVAWG PTVFATVIAF 

       250        260        270        280        290 
VSGYAVIAWF MKFISNKSFM PFVWYRIALG IAIIALVATG ALSPHAAESA G

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References

[1]"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed: 11572948] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.
[2]"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
Nat. Biotechnol. 21:526-531(2003) [PubMed: 12692562] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000030 Genomic DNA. Translation: BAC74732.1.
RefSeqNP_828197.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1217232.
GenomeReviewsGene locus SAV_7021 in contig BA000030_GR.
KEGGsma:SAV_7021.
NMPDRfig|227882.1.peg.7023.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG391969.
OMAESFEISF.

Enzyme and pathway databases

BioCycSAVE227882:SAV7021-MONOMER.
BRENDA3.6.1.27. 140873.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
[Tree]
InterProIPR003824. Bacitracin-R_BacA.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameUPPP2_STRAW
AccessionPrimary (citable) accession number: Q827A4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: February 9, 2010
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents