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Protein

Glycoprotein

Gene

G

Organism
Infectious hematopoietic necrosis virus (strain Oregon69) (IHNV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Binds to specific receptor at cellular surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the viral nucleocapsid into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in G, releasing a fusion hydrophobic peptide (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein
Alternative name(s):
Spike glycoprotein
Gene namesi
Name:G
OrganismiInfectious hematopoietic necrosis virus (strain Oregon69) (IHNV)
Taxonomic identifieri429315 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeNovirhabdovirus
Virus hostiSalmo [TaxID: 8028]
Proteomesi
  • UP000007211 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 461Virion surfaceSequence analysisAdd BLAST441
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 508IntravirionSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000028289921 – 508GlycoproteinAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi400N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi401N-linked (GlcNAc...); by hostSequence analysis1
Glycosylationi438N-linked (GlcNAc...); by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ82706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR001903. Rhabd_glycop.
IPR002417. Spike_prot.
[Graphical view]
PfamiPF00974. Rhabdo_glycop. 1 hit.
[Graphical view]
PRINTSiPR00796. SPIKEPROTEIN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q82706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTTITTPLI LILITCGANS QTVKPDTASE SDQPTWSNPL FTYPEGCTLD
60 70 80 90 100
KLSKVNASQL RCPRIFDDEN RGLIAYPTSI RSLSVGNDLG DIHTQGNHIH
110 120 130 140 150
KVLYRTICST GFFGGQTIEK ALVEMKLSTK EAGAYDTTTA AALYFPAPRC
160 170 180 190 200
QWYTDNVQND LIFYYTTQKS VLRDPYTRDF LDSDFIGGKC TKSPCQTHWS
210 220 230 240 250
NVVWMGDAGI PACDSSQEIK GHLFVDKISN RVVKATSYGH HPWGLHQACM
260 270 280 290 300
IEFCGKQWIR TDLGDLISVE YNSGAEILSF PKCEDKTVGM RGNLDDFAYL
310 320 330 340 350
DDLVKASESR EECLEAHAEI ISTNSVTPYL LSKFRSPHPG INDVYAMHKG
360 370 380 390 400
SIYHGMCMTV AVDEVSKDRT TYRAHRATSF TKWERPFGDE WEGFHGLHGN
410 420 430 440 450
NTTIIPDLEK YVAQYKTSMM EPMSIKSVPH PSILALYNET DVSGISIRKL
460 470 480 490 500
DSFDLQSLHW SFWPTISALG GIPFALLLAV AACCCWSGRP PTPSASQSIP

MYHLANRS
Length:508
Mass (Da):56,629
Last modified:November 1, 1996 - v1
Checksum:iFFD518E5BFF6A260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89213 Genomic RNA. Translation: CAA61498.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89213 Genomic RNA. Translation: CAA61498.1.

3D structure databases

ProteinModelPortaliQ82706.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR001903. Rhabd_glycop.
IPR002417. Spike_prot.
[Graphical view]
PfamiPF00974. Rhabdo_glycop. 1 hit.
[Graphical view]
PRINTSiPR00796. SPIKEPROTEIN.
ProtoNetiSearch...

Entry informationi

Entry nameiGLYCO_IHNVO
AccessioniPrimary (citable) accession number: Q82706
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.