Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q826P6 (DNLI_STRAW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable DNA ligase

EC=6.5.1.1
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene names
Name:lig
Ordered Locus Names:SAV_7136
OrganismStreptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680) [Complete proteome] [HAMAP]
Taxonomic identifier227882 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Probable DNA ligase HAMAP-Rule MF_00407
PRO_0000365240

Sites

Active site2101N6-AMP-lysine intermediate By similarity
Binding site2081ATP By similarity
Binding site2151ATP By similarity
Binding site2301ATP By similarity
Binding site2591ATP By similarity
Binding site2991ATP By similarity
Binding site3741ATP By similarity
Binding site3801ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q826P6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 83BCF5CCA086779F

FASTA51254,366
        10         20         30         40         50         60 
MLLSRLAHVS REVAATSARS RKIALLAELF RDADADDVPI VIPYLAGRLP QGRLGIGWKL 

        70         80         90        100        110        120 
LGRPVTPASE PSLTVRDVDA RLTAVGAVTG TGSQAGRGRL MGELMAAATD VEQAFLRGLL 

       130        140        150        160        170        180 
TGEVRQGALD AVAVEGLAEA TGAPPADVRR AVMLAGSLQT VARALLAEGP GALDGFRLTV 

       190        200        210        220        230        240 
GRPVLPMLAH TAGSVAEAVG KLGACAVEEK LDGIRVQLHR DGDHVRIYTR TLDDITDRLP 

       250        260        270        280        290        300 
ELTAAALELK GDRFILDGEV IALDGNGRPR SFQEIAGRVG SRVDVAAAAA SVPVSPVFFD 

       310        320        330        340        350        360 
ALSVDGRDLL DLPFTERHAE LARLVPEPLR VRRALVSGPD DGAAAETFLA DTLARGHEGV 

       370        380        390        400        410        420 
VVKALDAPYS AGRRGASWLK VKPVHTLDLV VLAAEWGHGR RTGKLSNLHL GARAADGSFA 

       430        440        450        460        470        480 
MLGKTFKGMT DAMLTWQTER LTELAVEENG SVVTVRPELV VEIAYDGLQK STRYPAGVTL 

       490        500        510 
RFARVVRYRE DKTPAEADTV ETLLAAHPEV TR 

« Hide

References

[1]"Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites."
Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M., Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T., Sakaki Y., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.
[2]"Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis."
Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., Sakaki Y., Hattori M., Omura S.
Nat. Biotechnol. 21:526-531(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31267 / DSM 46492 / JCM 5070 / NCIMB 12804 / NRRL 8165 / MA-4680.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000030 Genomic DNA. Translation: BAC74847.1.
RefSeqNP_828312.1. NC_003155.4.

3D structure databases

ProteinModelPortalQ826P6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING227882.SAV_7136.

Proteomic databases

PRIDEQ826P6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC74847; BAC74847; SAV_7136.
GeneID1211675.
KEGGsma:SAV_7136.
PATRIC23728432. VBIStrAve112782_7555.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1793.
HOGENOMHOG000036008.
KOK01971.
OMAGRPRPFQ.
OrthoDBEOG6Q8HXT.
ProtClustDBPRK03180.

Enzyme and pathway databases

BioCycSAVE227882:GJU1-7232-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNLI_STRAW
AccessionPrimary (citable) accession number: Q826P6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families