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Q82630

- RDRP_IBDVU

UniProt

Q82630 - RDRP_IBDVU

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Protein

RNA-directed RNA polymerase

Gene
VP1
Organism
Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities By similarity.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi259 – 2668GTP Reviewed prediction

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. RNA-protein covalent cross-linking Source: UniProtKB-KW
  2. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RDRP
Alternative name(s):
Protein VP1
Gene namesi
Name:VP1
OrganismiAvian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus)
Taxonomic identifieri644440 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesBirnaviridaeAvibirnavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Common turkey) [TaxID: 9103]
ProteomesiUP000007249: Genome

Subcellular locationi

Virion By similarity
Note: Minor amounts are incorporated in the virion By similarity.

GO - Cellular componenti

  1. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879RNA-directed RNA polymerasePRO_0000378410Add
BLAST

Post-translational modificationi

May exist in multiple phosphorylated forms.

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Interactioni

Subunit structurei

Interacts with VP3 in the cytoplasm By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ82630.
SMRiQ82630. Positions 31-804.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 598201RdRp catalyticAdd
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.287.540. 1 hit.
InterProiIPR007100. RNA-dir_pol_birnavirus.
IPR007098. RNA-dir_pol_mononegavirus.
IPR023218. UPF0291_struct_dom.
[Graphical view]
PfamiPF04197. Birna_RdRp. 1 hit.
[Graphical view]
PROSITEiPS50524. RDRP_DSRNA_BIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82630-1 [UniParc]FASTAAdd to Basket

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MSDVFNSPQA RSKISAAFGI KPTAGQDVEE LLIPKVWVPP EDPLASPSRL    50
AKFLRENGYK ILQPRSLPEN EEYETDQILP DLAWMRQIEG PVLKPTLSLP 100
IGDQEYFPKY YPTHRPSKEK PNAYPPDIAL LKQMIYLFLQ VPEATDNLKD 150
EVTLLTQNIR DKAYGSGTYM GQATRLVAMK EVATGRNPNK DPLKLGYTFE 200
SIAQLLDITL PVGPPGEDDK PWVPLTRVPS RMLVLTGDVD GEFEVEDYLP 250
KINLKSSSGL PYVGRTKGET IGEMIAISNQ FLRELSALLK QGAGTKGSNK 300
KKLLSMLSDY WYLSCGLLFP KAERYDKSTC CTKTRNKWSA QSSTHLMISM 350
ITWPVMSNSP NNVLNIEGCP SLYKFNPFRG GLNRIVEWIM APDEPKALVY 400
ADNIYIVHSN TWYSIDLEKG EANCTRQHMQ AAMYYILTRG WSDNGDPMFN 450
QTWATFAMNI APALVVDSSC LIMNLQIKTY GQGSGNAATF INNHLLSTLV 500
LDQWNLMKQP SPDSEEFKSI EDKLGINFKI ERSIDDIRGK LRQLVPLAQP 550
GYLSGGVEPE QPSPTVELDL LGWSATYSKD LGIYVPVLDK ERLFCSAAYP 600
KGVENKSLKS KVGIEQAYKV VRYEALRLVG GWNYPLLNKA CKNNASAARR 650
HLEAKGFPLD EFLAEWSELS EFGEAFEGFN IKLTVTPESL AELNRPVPPK 700
PPNVNRPVNT GGLKAVSNAL KTGRYRNEAG LSGLVLLATA RSRLQDAVKA 750
MAEAEKLHKS KPDDPDADWF ERSETLSDLL EKADIASKVA HSALVETSDA 800
LEAVQSTSVY TPKYPEVKNP QTASHPVVGL HLPAKRATGV QAALLGAGTS 850
RPMGMEAPTR SKNAVKMAKR RQRQKESRQ 879
Length:879
Mass (Da):97,691
Last modified:November 1, 1996 - v1
Checksum:i4E4BE23D99674DCB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92761 Genomic RNA. Translation: CAA63417.1.
RefSeqiNP_690839.1. NC_004179.1.

Genome annotation databases

GeneIDi956510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92761 Genomic RNA. Translation: CAA63417.1 .
RefSeqi NP_690839.1. NC_004179.1.

3D structure databases

ProteinModelPortali Q82630.
SMRi Q82630. Positions 31-804.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 956510.

Family and domain databases

Gene3Di 1.10.287.540. 1 hit.
InterProi IPR007100. RNA-dir_pol_birnavirus.
IPR007098. RNA-dir_pol_mononegavirus.
IPR023218. UPF0291_struct_dom.
[Graphical view ]
Pfami PF04197. Birna_RdRp. 1 hit.
[Graphical view ]
PROSITEi PS50524. RDRP_DSRNA_BIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Coding sequences of both genome segments of a European 'very virulent' infectious bursal disease virus."
    Brown M.D., Skinner M.A.
    Virus Res. 40:1-15(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_IBDVU
AccessioniPrimary (citable) accession number: Q82630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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