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Q82630 (RDRP_IBDVU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA-directed RNA polymerase

Short name=RDRP
EC=2.7.7.48
Alternative name(s):
Protein VP1
Gene names
Name:VP1
OrganismAvian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus) [Reference proteome]
Taxonomic identifier644440 [NCBI]
Taxonomic lineageVirusesdsRNA virusesBirnaviridaeAvibirnavirus
Virus hostGallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Common turkey) [TaxID: 9103]

Protein attributes

Sequence length879 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities By similarity.

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Subunit structure

Interacts with VP3 in the cytoplasm By similarity.

Subcellular location

Virion By similarity. Note: Minor amounts are incorporated in the virion By similarity.

Post-translational modification

May exist in multiple phosphorylated forms.

Sequence similarities

Contains 1 RdRp catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 879879RNA-directed RNA polymerase
PRO_0000378410

Regions

Domain398 – 598201RdRp catalytic
Nucleotide binding259 – 2668GTP Potential

Sequences

Sequence LengthMass (Da)Tools
Q82630 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 4E4BE23D99674DCB

FASTA87997,691
        10         20         30         40         50         60 
MSDVFNSPQA RSKISAAFGI KPTAGQDVEE LLIPKVWVPP EDPLASPSRL AKFLRENGYK 

        70         80         90        100        110        120 
ILQPRSLPEN EEYETDQILP DLAWMRQIEG PVLKPTLSLP IGDQEYFPKY YPTHRPSKEK 

       130        140        150        160        170        180 
PNAYPPDIAL LKQMIYLFLQ VPEATDNLKD EVTLLTQNIR DKAYGSGTYM GQATRLVAMK 

       190        200        210        220        230        240 
EVATGRNPNK DPLKLGYTFE SIAQLLDITL PVGPPGEDDK PWVPLTRVPS RMLVLTGDVD 

       250        260        270        280        290        300 
GEFEVEDYLP KINLKSSSGL PYVGRTKGET IGEMIAISNQ FLRELSALLK QGAGTKGSNK 

       310        320        330        340        350        360 
KKLLSMLSDY WYLSCGLLFP KAERYDKSTC CTKTRNKWSA QSSTHLMISM ITWPVMSNSP 

       370        380        390        400        410        420 
NNVLNIEGCP SLYKFNPFRG GLNRIVEWIM APDEPKALVY ADNIYIVHSN TWYSIDLEKG 

       430        440        450        460        470        480 
EANCTRQHMQ AAMYYILTRG WSDNGDPMFN QTWATFAMNI APALVVDSSC LIMNLQIKTY 

       490        500        510        520        530        540 
GQGSGNAATF INNHLLSTLV LDQWNLMKQP SPDSEEFKSI EDKLGINFKI ERSIDDIRGK 

       550        560        570        580        590        600 
LRQLVPLAQP GYLSGGVEPE QPSPTVELDL LGWSATYSKD LGIYVPVLDK ERLFCSAAYP 

       610        620        630        640        650        660 
KGVENKSLKS KVGIEQAYKV VRYEALRLVG GWNYPLLNKA CKNNASAARR HLEAKGFPLD 

       670        680        690        700        710        720 
EFLAEWSELS EFGEAFEGFN IKLTVTPESL AELNRPVPPK PPNVNRPVNT GGLKAVSNAL 

       730        740        750        760        770        780 
KTGRYRNEAG LSGLVLLATA RSRLQDAVKA MAEAEKLHKS KPDDPDADWF ERSETLSDLL 

       790        800        810        820        830        840 
EKADIASKVA HSALVETSDA LEAVQSTSVY TPKYPEVKNP QTASHPVVGL HLPAKRATGV 

       850        860        870 
QAALLGAGTS RPMGMEAPTR SKNAVKMAKR RQRQKESRQ 

« Hide

References

[1]"Coding sequences of both genome segments of a European 'very virulent' infectious bursal disease virus."
Brown M.D., Skinner M.A.
Virus Res. 40:1-15(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X92761 Genomic RNA. Translation: CAA63417.1.
RefSeqNP_690839.1. NC_004179.1.

3D structure databases

ProteinModelPortalQ82630.
SMRQ82630. Positions 31-804.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID956510.

Family and domain databases

Gene3D1.10.287.540. 1 hit.
InterProIPR007100. RNA-dir_pol_birnavirus.
IPR007098. RNA-dir_pol_mononegavirus.
IPR023218. UPF0291_struct_dom.
[Graphical view]
PfamPF04197. Birna_RdRp. 1 hit.
[Graphical view]
PROSITEPS50524. RDRP_DSRNA_BIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRDRP_IBDVU
AccessionPrimary (citable) accession number: Q82630
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families