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Protein

RNA-directed RNA polymerase

Gene

VP1

Organism
Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi259 – 2668GTPSequence Analysis

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. RNA-protein covalent cross-linking Source: UniProtKB-KW
  2. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RDRP
Alternative name(s):
Protein VP1
Gene namesi
Name:VP1
OrganismiAvian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus)
Taxonomic identifieri644440 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesBirnaviridaeAvibirnavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Meleagris gallopavo (Common turkey) [TaxID: 9103]
ProteomesiUP000007249 Componenti: Genome

Subcellular locationi

Virion By similarity
Note: Minor amounts are incorporated in the virion.By similarity

GO - Cellular componenti

  1. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 879879RNA-directed RNA polymerasePRO_0000378410Add
BLAST

Post-translational modificationi

May exist in multiple phosphorylated forms.

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Interactioni

Subunit structurei

Interacts with VP3 in the cytoplasm.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ82630.
SMRiQ82630. Positions 31-804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini398 – 598201RdRp catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.287.540. 1 hit.
InterProiIPR007100. RNA-dir_pol_birnavirus.
IPR007098. RNA-dir_pol_mononegavirus.
IPR023218. UPF0291_struct_dom.
[Graphical view]
PfamiPF04197. Birna_RdRp. 1 hit.
[Graphical view]
PROSITEiPS50524. RDRP_DSRNA_BIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q82630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDVFNSPQA RSKISAAFGI KPTAGQDVEE LLIPKVWVPP EDPLASPSRL
60 70 80 90 100
AKFLRENGYK ILQPRSLPEN EEYETDQILP DLAWMRQIEG PVLKPTLSLP
110 120 130 140 150
IGDQEYFPKY YPTHRPSKEK PNAYPPDIAL LKQMIYLFLQ VPEATDNLKD
160 170 180 190 200
EVTLLTQNIR DKAYGSGTYM GQATRLVAMK EVATGRNPNK DPLKLGYTFE
210 220 230 240 250
SIAQLLDITL PVGPPGEDDK PWVPLTRVPS RMLVLTGDVD GEFEVEDYLP
260 270 280 290 300
KINLKSSSGL PYVGRTKGET IGEMIAISNQ FLRELSALLK QGAGTKGSNK
310 320 330 340 350
KKLLSMLSDY WYLSCGLLFP KAERYDKSTC CTKTRNKWSA QSSTHLMISM
360 370 380 390 400
ITWPVMSNSP NNVLNIEGCP SLYKFNPFRG GLNRIVEWIM APDEPKALVY
410 420 430 440 450
ADNIYIVHSN TWYSIDLEKG EANCTRQHMQ AAMYYILTRG WSDNGDPMFN
460 470 480 490 500
QTWATFAMNI APALVVDSSC LIMNLQIKTY GQGSGNAATF INNHLLSTLV
510 520 530 540 550
LDQWNLMKQP SPDSEEFKSI EDKLGINFKI ERSIDDIRGK LRQLVPLAQP
560 570 580 590 600
GYLSGGVEPE QPSPTVELDL LGWSATYSKD LGIYVPVLDK ERLFCSAAYP
610 620 630 640 650
KGVENKSLKS KVGIEQAYKV VRYEALRLVG GWNYPLLNKA CKNNASAARR
660 670 680 690 700
HLEAKGFPLD EFLAEWSELS EFGEAFEGFN IKLTVTPESL AELNRPVPPK
710 720 730 740 750
PPNVNRPVNT GGLKAVSNAL KTGRYRNEAG LSGLVLLATA RSRLQDAVKA
760 770 780 790 800
MAEAEKLHKS KPDDPDADWF ERSETLSDLL EKADIASKVA HSALVETSDA
810 820 830 840 850
LEAVQSTSVY TPKYPEVKNP QTASHPVVGL HLPAKRATGV QAALLGAGTS
860 870
RPMGMEAPTR SKNAVKMAKR RQRQKESRQ
Length:879
Mass (Da):97,691
Last modified:October 31, 1996 - v1
Checksum:i4E4BE23D99674DCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92761 Genomic RNA. Translation: CAA63417.1.
RefSeqiNP_690839.1. NC_004179.1.

Genome annotation databases

GeneIDi956510.
KEGGivg:956510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92761 Genomic RNA. Translation: CAA63417.1.
RefSeqiNP_690839.1. NC_004179.1.

3D structure databases

ProteinModelPortaliQ82630.
SMRiQ82630. Positions 31-804.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi956510.
KEGGivg:956510.

Family and domain databases

Gene3Di1.10.287.540. 1 hit.
InterProiIPR007100. RNA-dir_pol_birnavirus.
IPR007098. RNA-dir_pol_mononegavirus.
IPR023218. UPF0291_struct_dom.
[Graphical view]
PfamiPF04197. Birna_RdRp. 1 hit.
[Graphical view]
PROSITEiPS50524. RDRP_DSRNA_BIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Coding sequences of both genome segments of a European 'very virulent' infectious bursal disease virus."
    Brown M.D., Skinner M.A.
    Virus Res. 40:1-15(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiRDRP_IBDVU
AccessioniPrimary (citable) accession number: Q82630
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 6, 2009
Last sequence update: October 31, 1996
Last modified: March 31, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.