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Q82630

- RDRP_IBDVU

UniProt

Q82630 - RDRP_IBDVU

Protein

RNA-directed RNA polymerase

Gene

VP1

Organism
Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities By similarity.By similarity

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi259 – 2668GTPSequence Analysis

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. RNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. RNA-protein covalent cross-linking Source: UniProtKB-KW
    2. viral genome replication Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

    Keywords - Biological processi

    Viral RNA replication

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-directed RNA polymerase (EC:2.7.7.48)
    Short name:
    RDRP
    Alternative name(s):
    Protein VP1
    Gene namesi
    Name:VP1
    OrganismiAvian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus)
    Taxonomic identifieri644440 [NCBI]
    Taxonomic lineageiVirusesdsRNA virusesBirnaviridaeAvibirnavirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]
    Meleagris gallopavo (Common turkey) [TaxID: 9103]
    ProteomesiUP000007249: Genome

    Subcellular locationi

    Virion By similarity
    Note: Minor amounts are incorporated in the virion.By similarity

    GO - Cellular componenti

    1. virion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 879879RNA-directed RNA polymerasePRO_0000378410Add
    BLAST

    Post-translational modificationi

    May exist in multiple phosphorylated forms.

    Keywords - PTMi

    Covalent protein-RNA linkage, Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with VP3 in the cytoplasm.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ82630.
    SMRiQ82630. Positions 31-804.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini398 – 598201RdRp catalyticPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.287.540. 1 hit.
    InterProiIPR007100. RNA-dir_pol_birnavirus.
    IPR007098. RNA-dir_pol_mononegavirus.
    IPR023218. UPF0291_struct_dom.
    [Graphical view]
    PfamiPF04197. Birna_RdRp. 1 hit.
    [Graphical view]
    PROSITEiPS50524. RDRP_DSRNA_BIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q82630-1 [UniParc]FASTAAdd to Basket

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    MSDVFNSPQA RSKISAAFGI KPTAGQDVEE LLIPKVWVPP EDPLASPSRL    50
    AKFLRENGYK ILQPRSLPEN EEYETDQILP DLAWMRQIEG PVLKPTLSLP 100
    IGDQEYFPKY YPTHRPSKEK PNAYPPDIAL LKQMIYLFLQ VPEATDNLKD 150
    EVTLLTQNIR DKAYGSGTYM GQATRLVAMK EVATGRNPNK DPLKLGYTFE 200
    SIAQLLDITL PVGPPGEDDK PWVPLTRVPS RMLVLTGDVD GEFEVEDYLP 250
    KINLKSSSGL PYVGRTKGET IGEMIAISNQ FLRELSALLK QGAGTKGSNK 300
    KKLLSMLSDY WYLSCGLLFP KAERYDKSTC CTKTRNKWSA QSSTHLMISM 350
    ITWPVMSNSP NNVLNIEGCP SLYKFNPFRG GLNRIVEWIM APDEPKALVY 400
    ADNIYIVHSN TWYSIDLEKG EANCTRQHMQ AAMYYILTRG WSDNGDPMFN 450
    QTWATFAMNI APALVVDSSC LIMNLQIKTY GQGSGNAATF INNHLLSTLV 500
    LDQWNLMKQP SPDSEEFKSI EDKLGINFKI ERSIDDIRGK LRQLVPLAQP 550
    GYLSGGVEPE QPSPTVELDL LGWSATYSKD LGIYVPVLDK ERLFCSAAYP 600
    KGVENKSLKS KVGIEQAYKV VRYEALRLVG GWNYPLLNKA CKNNASAARR 650
    HLEAKGFPLD EFLAEWSELS EFGEAFEGFN IKLTVTPESL AELNRPVPPK 700
    PPNVNRPVNT GGLKAVSNAL KTGRYRNEAG LSGLVLLATA RSRLQDAVKA 750
    MAEAEKLHKS KPDDPDADWF ERSETLSDLL EKADIASKVA HSALVETSDA 800
    LEAVQSTSVY TPKYPEVKNP QTASHPVVGL HLPAKRATGV QAALLGAGTS 850
    RPMGMEAPTR SKNAVKMAKR RQRQKESRQ 879
    Length:879
    Mass (Da):97,691
    Last modified:November 1, 1996 - v1
    Checksum:i4E4BE23D99674DCB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92761 Genomic RNA. Translation: CAA63417.1.
    RefSeqiNP_690839.1. NC_004179.1.

    Genome annotation databases

    GeneIDi956510.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92761 Genomic RNA. Translation: CAA63417.1 .
    RefSeqi NP_690839.1. NC_004179.1.

    3D structure databases

    ProteinModelPortali Q82630.
    SMRi Q82630. Positions 31-804.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 956510.

    Family and domain databases

    Gene3Di 1.10.287.540. 1 hit.
    InterProi IPR007100. RNA-dir_pol_birnavirus.
    IPR007098. RNA-dir_pol_mononegavirus.
    IPR023218. UPF0291_struct_dom.
    [Graphical view ]
    Pfami PF04197. Birna_RdRp. 1 hit.
    [Graphical view ]
    PROSITEi PS50524. RDRP_DSRNA_BIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Coding sequences of both genome segments of a European 'very virulent' infectious bursal disease virus."
      Brown M.D., Skinner M.A.
      Virus Res. 40:1-15(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiRDRP_IBDVU
    AccessioniPrimary (citable) accession number: Q82630
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3