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Q82573

- PB2_I47A0

UniProt

Q82573 - PB2_I47A0

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Protein
Polymerase basic protein 2
Gene
PB2
Organism
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication By similarity.

GO - Molecular functioni

  1. RNA binding Source: InterPro
  2. RNA-directed RNA polymerase activity Source: InterPro

GO - Biological processi

  1. 7-methylguanosine mRNA capping Source: UniProtKB-KW
  2. cap snatching Source: UniProtKB-KW
  3. suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
  4. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cap snatching, Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, mRNA capping, mRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase basic protein 2
Alternative name(s):
RNA-directed RNA polymerase subunit P3
Gene namesi
Name:PB2
OrganismiInfluenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
Taxonomic identifieri380282 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
Virus hostiAves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationi

GO - Cellular componenti

  1. host cell mitochondrion Source: UniProtKB-SubCell
  2. host cell nucleus Source: UniProtKB-SubCell
  3. virion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host mitochondrion, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Polymerase basic protein 2
PRO_0000078816Add
BLAST

Interactioni

Subunit structurei

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

Structurei

3D structure databases

ProteinModelPortaliQ82573.
SMRiQ82573. Positions 319-483, 685-759.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi736 – 7394Nuclear localization signal By similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view]
PfamiPF00604. Flu_PB2. 1 hit.
[Graphical view]
ProDomiPD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q82573-1 [UniParc]FASTAAdd to Basket

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MERIKELRNL MSQSRTREIL TKTTVDHMAI IKKYTSGRQE KNPSLRMKWM    50
MAMKYPITAD RRITEMIPER NEQGQTLWSK MNDAGSDRVM VSPLAVTWWN 100
RNGPMTSTVH YPKIYKTYFE KVERLKHGTF GPVHFRNQVK IRRRVDINPG 150
HADLSAKEAQ DVIMEVVFPN EVGARILTSE SQLTITKEKK EELQDCKISP 200
LMVAYMLERE LVRKTRFLPV AGGTSSVYIE VLHLTQGTCW EQMYTPGGEV 250
RNDDVDQSLI IAARNIVRRA AVSADPLASL LEMCHSTQIG GTRMVDILRQ 300
NPTEEQAVNI CKAAMGLRIS SSFSFAGFTF KRTSGSSVKR EEEVLTGNLQ 350
TLKIRVHEGY EEFTMVGKRA TAILRKTTRR LIQLIVSGRD EQSIAEAIIV 400
AMVFSQEDCM IKAVRGDLNF VNRANQRLNP MHQLLRHFQK DAKVLFQNWG 450
IEHIDNVMGM IGILPDMTPS TEMSMRGVRV SKMGVDEYSS AERVVVSIDR 500
FLRVRDQRGN VLLSPEEVSE TQGTEKLTIT YSSSMMWEIN GPESVLVNTY 550
QWIIRNWETV KIQWSQNPTM LYNKIEFEPF QSLVPKAIRG QYSGFVRTLF 600
QQMRDVLGTF DTTQIIKLLP FAAAPPKQSR MQFSSLTVNV RGSGMRILVR 650
GNSPVFNYNK TTKRLTVLGK DAGTLTEDPD EGTAGVESAV LRGFLILGKE 700
DRRYGPALSI NELSNLAKGE KANVLIGQGD VVLVMKRKRD SSILTDSQTA 750
TKRIRMAIN 759
Length:759
Mass (Da):86,124
Last modified:November 1, 1996 - v1
Checksum:i8CC5CF76DAF86072
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti482 – 4821K → R in strain: A/Fort Monmouth/1/47-MA.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99035 Genomic RNA. Translation: CAA67496.1.
X99036 Genomic RNA. Translation: CAA67497.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99035 Genomic RNA. Translation: CAA67496.1 .
X99036 Genomic RNA. Translation: CAA67497.1 .

3D structure databases

ProteinModelPortali Q82573.
SMRi Q82573. Positions 319-483, 685-759.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR001591. RNA_pol_PB2_orthomyxovir.
[Graphical view ]
Pfami PF00604. Flu_PB2. 1 hit.
[Graphical view ]
ProDomi PD001667. RNA_pol_PB2_orthomyxovir. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Mutations in the hemagglutinin and matrix genes of a virulent influenza virus variant, A/FM/1/47-MA, control different stages in pathogenesis."
    Smeenk C.A., Wright K.E., Burns B.F., Thaker A.J., Brown E.G.
    Virus Res. 44:79-95(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiPB2_I47A0
AccessioniPrimary (citable) accession number: Q82573
Secondary accession number(s): Q82574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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