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Protein

Hemagglutinin

Gene
N/A
Organism
Influenza A virus (A/swine/St-Hyacinthe/148/1990(H1N1))
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei204N-acetyl-D-glucosamineCombined sources1

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HemagglutininUniRule annotationSAAS annotation

Keywords - Biological processi

Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotation, Clathrin-mediated endocytosis of virus by hostSAAS annotation, Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
HemagglutininSAAS annotation
OrganismiInfluenza A virus (A/swine/St-Hyacinthe/148/1990(H1N1))Imported
Taxonomic identifieri382853 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

  • Host apical cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei531 – 554HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21Interchain (with C-481)Combined sources
Disulfide bondi59 ↔ 292Combined sources
Disulfide bondi72 ↔ 84Combined sources
Disulfide bondi107 ↔ 153Combined sources
Disulfide bondi296 ↔ 320Combined sources
Disulfide bondi481Interchain (with C-21)Combined sources
Disulfide bondi488 ↔ 492Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2.UniRule annotationSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RV0X-ray2.50H/J/L18-339[»]
I/K/M345-504[»]
1RVTX-ray2.50H/J/L14-339[»]
I/K/M345-504[»]
ProteinModelPortaliQ82500.
SMRiQ82500.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ82500.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 239Galactose bindingCombined sources4

Sequence similaritiesi

Belongs to the influenza viruses hemagglutinin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

Q82500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAILLVLLC AFAATNADTL CIGYHANNST DTVDTVLEKN VTVTHSVNLL
60 70 80 90 100
EDSHNGKLCR LGGIAPLQLG KCNIAGWLLG NPECDLLLTV SSWSYIVETS
110 120 130 140 150
NSDNGTCYPG DFIDYEELRE QLSSVSSFEK FEIFPKTSSW PNHETTRGVT
160 170 180 190 200
AACPYAGASS FYRNLLWLVK KEXSYPKLSK SYVNNKGKEV LVLWGVHHPP
210 220 230 240 250
TSTDQQSLYQ NADAYVSVGS SKYDRRFTPE IAARPKVRGQ AGRMNYYWTL
260 270 280 290 300
LEPGDTITFE ATGNLVAPRY AFALNRGSES GIITSDAPVH DCDTKCQTPH
310 320 330 340 350
GAINSSLPFQ NIHPVTIGEC PKYVKSTKLR MVTGLRNIPS IQSRGLFGAI
360 370 380 390 400
AGFIEGGWTG LIDGWYGYHH QNGQGSGYAA DQKSTQNAID GITNKVNSVI
410 420 430 440 450
EKMNTQFTVV GKEFNNLERR IKNLNKKVDD GFLDVWTYNA ELLVLLENER
460 470 480 490 500
TLDFHDSNVK NLYEKARSQL RNNAKEIGNG CFEFYHKCDD ACMESVRNGT
510 520 530 540 550
YDYPKYSEES KLNREEIDGV KLESMMVYQI LAIYSTVASS LVLLVSLGAI
560
SFWMCSNGSL QCRICI
Length:566
Mass (Da):62,924
Last modified:November 1, 1996 - v1
Checksum:iA9C35670108B72A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11703 Genomic RNA. Translation: AAA91616.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11703 Genomic RNA. Translation: AAA91616.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RV0X-ray2.50H/J/L18-339[»]
I/K/M345-504[»]
1RVTX-ray2.50H/J/L14-339[»]
I/K/M345-504[»]
ProteinModelPortaliQ82500.
SMRiQ82500.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ82500.

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ82500_9INFA
AccessioniPrimary (citable) accession number: Q82500
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.