Reviewed, UniProtKB/Swiss-Prot Q824K8 (HEMH_CHLCV)

Names and origin

Protein names

Recommended name:
    Ferrochelatase
    EC=4.99.1.1
Alternative name(s):
    Protoheme ferro-lyase
    Heme synthetase

Gene names

Name:	hemH
Ordered Locus Names:	CCA_00137

Organism

Chlamydophila caviae [Complete proteome] [HAMAP]

Taxonomic identifier

83557 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydophila

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Ferrochelatase HAMAP MF_00323		PRO_0000175127
Sites
	Metal binding	186	1	Iron By similarity
	Metal binding	264	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q824K8-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B82BE5123E92AAF9	FASTA	318	36,077
	10 20 30 40 50 60 MVSAYLLANF GGPRHSNDIE VFLTSLLTDR DVTGGFLPSF IHKRLFSFIA KKRALKVLPQ 70 80 90 100 110 120 YNCIGGFSPI YQDTELLAET LSSHLDAPVI TFHRYLPDTH PHTIQQLKTL GDFPIVGVPL 130 140 150 160 170 180 FPHFTYAVTG SIVRFIHNQL PLLNISWVSH FGNHPEFISC MMDHILKFLQ SHDISTHDCC 190 200 210 220 230 240 LLFSAHGLPM RHVNKGDPYN MQCEKSFRAI SERLPNIETH LCYQSKFGPG KWLSPSTKDL 250 260 270 280 290 300 CATLKTDKKH VLIVPFGFTS DHIETLYEIE KEYIAVLIDK GYQALRVPAI YQSSQWVESL 310 ATIIQSTPHV EKKSLIKS

References

[1]

"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae." Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. , Rank R.G., Bavoil P.M., Fraser C.M. Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GPIC.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE015925 Genomic DNA. Translation: AAP04889.1.
RefSeq	NP_829011.1.
3D structure databases
SMR	Q824K8. Positions 3-307.
ModBase	Search...
Genome annotation databases
GeneID	1217822.
GenomeReviews	Gene locus CCA_00137 in contig AE015925_GR.
KEGG	cca:CCA00137.
TIGR	CCA_00137.
Phylogenomic databases
HOGENOM	HBG697135.
OMA	PEMPNAS.
PhylomeDB	Q824K8.
Enzyme and pathway databases
BioCyc	CCAV227941:CCA_00137-MONOMER.
BRENDA	4.99.1.1. 304519.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. hemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_CHLCV

Accession

Primary (citable) accession number: Q824K8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	June 1, 2003
Last modified:	February 9, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)