Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q824K8 (HEMH_CHLCV) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:CCA_00137
OrganismChlamydophila caviae [Complete proteome] [HAMAP]
Taxonomic identifier83557 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydophila

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Ferrochelatase HAMAP MF_00323
PRO_0000175127

Sites

Metal binding1861Iron By similarity
Metal binding2641Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q824K8 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: B82BE5123E92AAF9

FASTA31836,077
        10         20         30         40         50         60 
MVSAYLLANF GGPRHSNDIE VFLTSLLTDR DVTGGFLPSF IHKRLFSFIA KKRALKVLPQ 

        70         80         90        100        110        120 
YNCIGGFSPI YQDTELLAET LSSHLDAPVI TFHRYLPDTH PHTIQQLKTL GDFPIVGVPL 

       130        140        150        160        170        180 
FPHFTYAVTG SIVRFIHNQL PLLNISWVSH FGNHPEFISC MMDHILKFLQ SHDISTHDCC 

       190        200        210        220        230        240 
LLFSAHGLPM RHVNKGDPYN MQCEKSFRAI SERLPNIETH LCYQSKFGPG KWLSPSTKDL 

       250        260        270        280        290        300 
CATLKTDKKH VLIVPFGFTS DHIETLYEIE KEYIAVLIDK GYQALRVPAI YQSSQWVESL 

       310 
ATIIQSTPHV EKKSLIKS

« Hide

References

[1]"Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC): examining the role of niche-specific genes in the evolution of the Chlamydiaceae."
Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T., Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A., Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O., Salzberg S.L., Hsia R.-C., McClarty G. expand/collapse author list , Rank R.G., Bavoil P.M., Fraser C.M.
Nucleic Acids Res. 31:2134-2147(2003) [PubMed: 12682364] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GPIC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE015925 Genomic DNA. Translation: AAP04889.1.
RefSeqNP_829011.1. NC_003361.3.

3D structure databases

ProteinModelPortalQ824K8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1217822.
GenomeReviewsGene locus CCA_00137 in contig AE015925_GR.
KEGGcca:CCA00137.
PATRIC20269276. VBIChlCav107360_0141.
TIGRCCA_00137.

Phylogenomic databases

HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBQ824K8.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycCCAV227941:CCA_00137-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_CHLCV
AccessionPrimary (citable) accession number: Q824K8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents